Authors: Prathap Jayaram, Gu Eon Kang, Brett L Heldt, Olumide Sokunbi, Bo Song, Peter C Yeh, Max Epstein, Theodore B Shybut, Brendan H Lee, Bijan Najafi
Summary: Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patient with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking.
Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time-points (6 weeks).
Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II–III), who underwent a single ultrasound-guided LR-PRP injection.
Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters.
Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient reported outcomes at early time points in patients with KOA.
Source: Regenerative Medicine, 2021