Authors:
Kiranmai Gumireddy, Dr., Douglas D. Young, Xin Xiong, Dr., John B. Hogenesch, Prof. Dr., Qihong Huang, Prof. Dr., Alexander Deiters, Prof. Dr.
Summary:
MicroRNAs (miRNAs) have recently emerged as an important class of gene regulators, and their misregulation has been linked to a variety of cancers. Small-molecule inhibitors of miRNAs would be important tools for the elucidation of the detailed mechanisms of miRNA function and should serve as lead structures for the development of new therapeutic agents. We report a cellular screen for miRNA-pathway inhibitors and the first small-molecule modifiers of miRNA function.
Source:
Angewandte Chemie; Vol. 120, Issue 39, 7592-7594 (08/19/08)