Authors:
Debanjan Sarkar, Praveen Kumar Vemula, Grace S. L. Teo, Dawn Spelke, Rohit Karnik, Le Y. Wee, and Jeffrey M. Karp
Summary:
Covalently conjugated sialyl Lewis X (SLeX) on the mesenchymal stem cell (MSC) surface through a biotin−streptavidin bridge imparts leukocyte-like rolling characteristics without altering the cell phenotype and the multilineage differentiation potential. We demonstrate that the conjugation of SLeX on the MSC surface is stable, versatile, and induces a robust rolling response on P-selectin coated substrates. These results indicate the potential to increase the targeting efficiency of any cell type to specific tissue.
Source:
Bioconjugate Chemistry; 19(11), 2105-2109 (10/31/08)