Authors:
Evgeny V Denisov, Nikolay A Skryabin, Stanislav A Vasilyev, Tatiana S Gerashchenko, Igor N Lebedev, Marina V Zavyalova, Nadezhda V Cherdyntseva, & Vladimir M Perelmuter
First Paragraph of PostScript:
Invasive micropapillary carcinoma (IMPC) is a rare (up to 2%) and aggressive form of breast cancer. IMPC shows high intratumoral morphological diversity, which represents the degree of cell differentiation, as well as the architectural and invasive growth patterns of tumour cells. Morphologically, these tumours are characterised by the presence of hollow-like (tubular) and morula-like (alveolar) structures of cuboidal-to-columnar neoplastic cells, which are surrounded by empty spaces (retraction clefts) and display an inversion of cell polarity, detected by aberrant localisation of glycoprotein MUC-1 at the stromal–basal surface. In addition, micropapillary tumour clusters can be represented by tumour cells arranged in solid patterns (structures), trabecular structures and discrete (small) groups. It has been suggested that morphological diversity of IMPC is related to chemotherapy resistance,7 whereas the presence of retraction clefts around tumour clusters is associated with increased lymphangiogenesis and lymph node metastasis…
Source:
Journal of Clinical Pathology; Vol. 68, Issue 9, 758-762 (06/15/15)