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Adult Stem Cell Breakthrough: First Tissue-Engineered Trachea Successfully Transplanted

“This successful treatment manifestly demonstrates the potential of adult stem cells to save lives,” says Dr. Anthony Hollander.

The first tissue-engineered trachea (windpipe), utilizing the patient’s own stem cells, has been successfully transplanted into a young woman with a failing airway. The bioengineered trachea immediately provided the patient with a normally functioning airway, thereby saving her life.

These remarkable results provide crucial new evidence that adult stem cells, combined with biologically compatible materials, can offer genuine solutions to other serious illnesses.

In particular, the successful outcome shows it is possible to produce a tissue-engineered airway with mechanical properties that permit normal breathing and which is free from the risks of rejection seen with conventional transplanted organs. The patient has not developed antibodies to her graft, despite not taking any immunosuppressive drugs. Lung function tests performed 2 months after the operation were all at the better end of the normal range for a young woman.

The loss of a normal airway is devastating, but previous attempts to replace large airways have met serious problems. The 30-year-old mother of two, suffering from a collapsed airway following a severe case of TB, was hospitalized in March 2008 with acute shortness of breath rendering her unable to carry out simple domestic duties or care for her children. The only conventional option remaining was a major operation to remove her left lung which carries a risk of complications and a high mortality rate.

Based on successful laboratory work previously performed by the team, and given the urgency of the situation, it was proposed that the lower trachea and the tube to the patient’s left lung (bronchus) should be replaced with a bioengineered airway based on the scaffold of a human trachea.

A 7-centimeter tracheal segment was donated by a 51-year-old transplant donor who had died of cerebral hemorrhage. Spain has a policy of assumed consent for organ donation. Using a new technique developed in Padua University, the trachea was decellularized over a 6-week period so that no donor cells remained.

Stem cells were obtained from the recipient’s own bone marrow, grown into a large population in Professor Martin Birchall’s lab at the University of Bristol, and matured into cartilage cells (chondrocytes) using an adapted method originally devised for treating osteoarthritis by Professor Anthony Hollander at the University of Bristol.

The donor trachea was then seeded with chondrocytes on the outside, using a novel bioreactor which incubates cells, developed at the Politecnico di Milano, Italy, allowing them to migrate into the tissue under conditions ideal for each individual cell type. In order to replicate the lining of the trachea, epithelial cells were seeded onto the inside of the trachea using the same bioreactor.

Four days after seeding, the graft was used to replace the patient’s left main bronchus. The operation was performed in June 2008 at the Hospital Clinic, Barcelona, by Professor Paolo Macchiarini of the University of Barcelona.

Professor Macchiarini, lead author on the paper, said, “We are terribly excited by these results. Just 4 days after transplantation the graft was almost indistinguishable from adjacent normal bronchi. After 1 month, a biopsy elicited local bleeding, indicating that the blood vessels had already grown back successfully.”

Martin Birchall, Professor of Surgery at the University of Bristol, added, “Surgeons can now start to see and understand the very real potential for adult stem cells and tissue engineering to radically improve their ability to treat patients with serious diseases. We believe this success has proved that we are on the verge of a new age in surgical care.”

Anthony Hollander, Arthritis Research Campaign Professor of Rheumatology and Tissue Engineering at the University of Bristol, concurred. “This successful treatment manifestly demonstrates the potential of adult stem cells to save lives,” he said.

The patient, Claudia Castillo, a young woman from Colombia but now living in Spain, had no complications from the operation and was discharged from hospital on the tenth post-operative day. She has remained well since and has a normal quality of life. She is able to care for her children, walk up two flights of stairs, and occasionally go out dancing in the evenings.

She said, “Above all I would like to thank Dr. Macchiarini and his medical team who did the research, for the time and dedication they devoted to my case to make sure that everything turned out alright.”

Illustration: The transplanted trachea. –University of Bristol.

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University of Bristol News Release (11/19/08)

Science Daily (11/18/08)

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Abstract (The Lancet; (11/19/08))

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Molecular Muscle: Small Parts of a Big Protein Play Key Roles in Building Tissues New Study Pinpoints Why Some Microbial Genes are More Promiscuous Than Others Trapping Prostate Cancer Cells to Keep Them from Spreading Provides Hope Two-Pronged Approach Brings Hope for Bowel Cancer Treatment New Cell Therapy a Promising Atherosclerosis Treatment Gene-Fuelled Transporter Causes Breast Cancer Cells to Self-Destruct Gene Responsible for Severe Osteoporosis Disorder Discovered Genetic Abnormalities Associated With the Creation of Stem Cells Discovered Stem Cell Study Could Aid Motor Neuron Disease Research Scientists Discover Cause of Rare Skin Cancer That Heals Itself Human Umbilical Cord Blood Cells Aid Diabetic Wound Healing Cancer-Related Pathways Reveal Potential Treatment Target for Congenital Heart Disease Personalized Medicine Comes Within Reach World’s First Chemical Guided Missile Could Be the Answer to Wiping Out Cancer Canadian Researchers First Worldwide to Generate Pluripotent Stem Cells From Horses U of Alberta Researcher Discovers Potential Cancer Therapy Target How Nasal Stem Cells Might Prevent Childhood Deafness Boosting Body’s Immune Response May Hold Key to HIV Cure McMaster Discovery Provides New Insights into Pluripotent Stem Cell Biology Early Infusion of Donor T Regulatory Cells Prevents Graft-Versus-Host Disease and Enhances Immune Recovery in High-Risk Blood Cancer Patients Erg Gene Key to Blood Stem Cell 'Self-Renewal' Reprogrammed Stem Cells Hit a Roadblock Partnership of Genes Affects the Brain's Development Immune Interaction Optimizes Fetal Nourishment During Pregnancy New Anti-HIV Gene Therapy Makes T-Cells Resistant to HIV Infection DMP1 Protein Inhibits Angiogenesis, Could Lead to New Treatments Against Cancer and Other Diseases Research Shows How Pathogenic Bacteria Hide Inside Host Cells Dynamic Systems in Living Cells Break the Rules Uncovering the Trail Behind Growing Too Old, Too Soon Blocking Rogue Gene Could Stop the Spread of Most Cancers Red Blood Cell Hormone Modulates the Immune System Patient-Derived Stem Cells Could Help Test Cardiac Disease Treatments Skin Provides Australia's First Adult Stem Cells for Friedreich Ataxia Nanodisk Gene Therapy Scientists Now Know Why Some Cancers Become Malignant and Others Don't Scientists Bring New Hopes to Translate Human Stem Cell Technologies to the Clinic Scientists Find the “Master Switch” for Key Immune Cells in Inflammatory Diseases Researchers Find Critical Link Between Down Syndrome and Alzheimer’s Disease Punctuated Evolution in Cancer Genomes Australian Researchers Identify Gene Mutations That Sabotage Kidney Function Two Genes Linked to Common Gynecological Disease Study Reveals New Possibility of Reversing Damage Caused by MS Some Brain Tumors Mimic the Genetic Program of Germline Cells Leukemia Stem Cell Discovery Degradable Scaffolds for Tissues A Double Block of Blood Vessels to Starve Cancerous Tumors Medicine: Alzheimer's and Heart Attacks Share the Same Genes TB Bacteria Use the Body's Stem Cells to Protect Themselves Study Shows That Blood Stem Cells are Influenced by Their Offspring Fitting a Biological Nanopore into a Man-Made One, New Ways to Analyze DNA New Microscope Reveals Ultrastructure of Cells Transcription Factor Scan Identifies Genetic Cause for Inherited Blindness Overactive FTO Gene Does Cause Overeating and Obesity Team Finds Mutation Involved in Macular Degeneration Origin of Cells Associated With Nerve Repair Discovered Umbilical Cord Cells May Treat Arthritis Rogue Gene Hijacks Stem Cells to Jumpstart Human Cancer Breakthrough in Cancer Vaccine Research ISMETT Celebrates Transplant Number 1000 Pediatric Living-Related Liver Transplant at ISMETT Scientists Find Non-Viral Pathway of Blood Cancer Development How Do We Kill Rogue Cells? Assassin's Tricks Revealed Not All Stem Cells the Same, Say McMaster Researchers Scientists Turn Stem Cells into Cells for Cartilage Repair Scientists Uncover Strategy to Effectively Target Drug Resistant Childhood Cancers Stem Cells Shape Up to Their Surroundings Scientists Reveal Gut Stem Cell Secrets Visionary Stem Cell Technique Offers New Potential to Treat Blindness Scientists Unravel Genetic Risk of Bowel Cancer Scientists 'Clone' Human Virus Responsible for Congenital Malformations and Other Life-Threatening Diseases Major Genetic Risk Factor for the Most Common Form of Glaucoma Discovered Uncovered: New Ovarian Cancer Gene (A Connection Between Cancer and Endometriosis) Twins Help Researchers to Find Genes for Blindness Identifying Stem Cell Suicide Triggers with ROCK Accelerating the Understanding of Personalized Medicine B Vitamins Slow Brain Atrophy in People with Memory Problems Smoking Damages Fertility Scientific Breakthrough to Pave the Way for Human Stem Cell Factories First Genetic Link to Common Migraine Exposed Insulin Resistance, Type 2 Diabetes Linked to Plaques Associated With Alzheimer's Disease Scientists Describe How Physical Environment Influences Stem Cell Development Important Breakthrough in Origins of Aggressive Breast Cancer “Toolbox of MiniPromoters” for Gene Research and Therapy Unveiled All Genes in One Go Seeing the World With New Eyes: Biosynthetic Corneas Restore Vision in Humans Gene Therapy to Treat Epilepsy a Step Closer Liver Cells Created From Patients' Skin Cells New Stem Cell Discovery a Preliminary Step for Regenerative Medicine Slippery DNA Holds Clues to Fighting Diseases That Progress with Age Otago Researcher Helps Identify Gene Linked to TB Susceptibility in Africans Stem Cells from the Thymus Reprogrammed to Become Skin Stem Cells ‘Starvation Gene’ Could Make Resistance Futile for Ovarian Cancer Cells Personalized Genome Sequencing in Cancer Treatment—A Major Breakthrough in Care Genetic Signature in TB Patients Sheds Light on Disease Genetic Differences That Make Some People Susceptible to Meningitis Revealed Gene Affecting Chronic Pain Identified--Opens Way for New Treatment Approach Herpes Virus Treats Head and Neck Cancer Patients Manipulating Cells With a Micro-Suction Cup New Discovery Brings Hope to Treatment of Incurable Blood Cancer Scientists 'Reprogram' Mouse Fat Cells Into Clinically Useful Stem Cells Toxic Trio Identified as the Basis of Celiac Disease Bid to Aid Transplant Cancer Patients Gene Find Offers Breast Cancer Hope Potential Cure Discovered for Degenerative Vision Diseases Leading to Terminal Blindness Cells' Grouping Tactic Points to New Cancer Treatments Finding May Pave Way for New Treatments for Muscle Wasting Diseases New Discovery in Nerve Regrowth Tel Aviv University Develops Method for Tracking Adult Stem Cells as They Regress UK Clinical Trial: Stem Cells to Treat Knee Osteoarthritis Stem Cell Transplantation of Therapy-Resistant Chronic Leukemia Successful Reversal of Fortune for Parkinson's Disease Transplant Treatment Potential Cancer Cause Uncovered Revolutionary Medical Dressing Uses Nanotechnology to Fight Infection Prostate Cancer Study's Dramatic Results Stem Cell Therapy May Provide New Approach to Fight Infection 12 New Genes Linked to Type 2 Diabetes Microbial Protein Restores Vision in Blind Animals Identification of a Novel Tumor Suppressor Bees Help to Beat MRSA Bugs Mechanism Explains Complications Associated With Diabetes Stem Cell Breakthrough Offers New Hope for Lung Disease Patients Scientists Identify Three New Genetic Variants That Increase Testicular Cancer Risk Mechanism Behind Three Cancer-Causing Genes in Acute Lymphoblastic Leukemia Rare Genetic Variations Involving Whole Sections of DNA Implicated in Autism Reprogramming Immune System Cells to Produce Natural Killer Cells for Cancer Obstacles to Stem Cell Therapy Cleared Dental Pulp Cells for Stem Cell Banking How the Wrong Genes Are Repressed Down's Syndrome Chromosome Yields More Cancer-Blocking Genes Ancient Viral Invasion That Shaped the Human Genome Found Sleeping Sickness Study Offers Insight Into Human Cells New Therapy Offers Hope to Spinal Muscular Atrophy Patients Scientists Find Genes Associated With Throat Cancer Transplant Tolerance 'Signature' Identified Progress in Exploring New Avenues for Brain Repair New Findings Complicate Use of Stem Cells Study Sheds Light Into the Nature of Embryonic Stem Cells Harnessing the Power of Stem Cells to Unlock the Secrets of Motor Neuron Disease Stem Cells From Adipose Tissue Turned Into Cardiac Myocytes: Achievement Paves Way for Future Heart Disease Therapies Genetic Link to Risk for Diabetes and Weight Gain: New Study Funnel Vision: New Info About How Cells in the Eye Help Guide Light Into the Retina Researchers Discover New Mechanism in Stem Cell Regulation Researchers Agree on Future of MS Stem Cell Research Researchers Design New Biomaterial That Mimics Muscle Elasticity ‘Junk DNA’ Drives Cancer Growth Researchers Modify Virus to Hunt Down and Wipe Out Cancer Cells Finding Has Direct Impact on Regenerative Medicine and Assisted Reproduction Link: Ovarian Hormone to Breast Stem Cells Growth Bone-Marrow Stem Cells in MS Show Promise Prenatal Smoking Can Lead to Psychiatric Problems in Children Scientists Create Artificial Human Skin with Biomechanical Properties Using Tissue Engineering Chinese Scientists Discover Marker Indicating the Developmental Potential of Stem Cells Major Breakthrough Offers Hope of Preventing Mitochondrial Diseases Substance in Breast Milk Kills Cancer Cells New Discovery Could Speed Up Liver Repair Hormone Sensitivity of Breast Stem Cells Presents Drug Target Insulin-Producing Cells Can Regenerate in Diabetic Mice Gene Therapy Boosts Recovery From Heart Attack Potential to Produce the Large Quantities of Human Embryonic Stem Cells Required for Transplantation Hormone Replacement in Joint Fluid Has Potential Regenerative Effect Tomato Genes Produce Promising Results Against Brain Tumors Using Stem Cells to Mend Damaged Hips Surgeons Transplant New Trachea Into Child Using His Own Stem Cells to Rebuild Airway How to Fortify the Immunity of HIV Patients Gut Flora Genes Dwarf Human Genome Predicting the Fate of Stem Cells Research Builds on Genetic Link to Autism and Schizophrenia How Nerve Cells Grow Genetic Link Between Mammographic Density and Breast Cancer Study: Stem Cells Sabotage Their Own DNA to Produce New Tissues Bacteria Toxic to Wound-Treating Maggots Stem Cells Rescue Nerve Cells by Direct Contact Novel Theory for Mammalian Stem Cell Regulation How to Shoot the Messenger Targeting Cancer Stem Cells in the Lab Did Bacteria Develop Into More Complex Cells Much Earlier in Evolution Than Thought? Scientists Map Epigenome of Human Stem Cells During Development Regenerative Medicine and Transplantations: How the Immune System Produces T Cells 'Junk DNA' Could Spotlight Breast and Bowel Cancer 'Fountain of Youth' for Stem Cells? Metastasis Formation Revealed in Detail in Real Time Acutely Damaged Livers may be Repaired via Transplanted Hepatocytes Leprosy Susceptibility Genes Identified Gene Identified as Cause of Some Forms of Intellectual Disability Stroke Drug Kills Cancer Cells and Leaves Normal Cells Intact Why Cancer Cells Just Won't Die: Researcher Identifies Protein Which Regulates Cell Suicide It Takes Two to Infect: Structural Biologists Shed Light on Mechanism of Invasion Protein Genetic Analysis Helps Dissect Molecular Basis of Cardiovascular Disease Polyphenols and Polyunsaturated Fatty Acids Boost the Birth of New Neurons, Study Finds Umbilical Cord Blood Stem Cell Transplant May Help Lung, Heart Disorders New Understanding About Mechanism for Cell Death After Stroke Leads to Possible Therapy First Reconstitution of an Epidermis from Human Embryonic Stem Cells Scientists Discover Cells That Control Inflammation in Chronic Disease Cross-Country Runabouts: Immune Cells on the Move Paradoxical Protein Might Prevent Cancer Survival of the Healthiest: Selective Eradication of Malignant Cells Dementia: Rare Brain Disorder is Highly Hereditary Gene Therapy Repairs Injured Human Donor Lungs for the First Time Testicular Tumors May Explain Genetic Mutations in Children Adipose-Derived Stem and Regenerative Cells Show Potential in First-in-Man Treatment of Stress Urinary Incontinence Blood Counts Are Clues to Human Disease Research Points to Potential Chink in Cancer's Armor Sophisticated Genetic Engineering Improves Insulin-Producing Beta Cells Cholesterol Necessary for Brain Development, Study Finds Step Forward for Nanotechnology: Controlled Movement of Molecules Retinal Rescue: Cells Derived From Human Embryonic Stem Cells Reverse Retinal Degeneration Discovery of Regulatory Role of Key Molecule: Step Towards Future Gene Therapy to Control Disease Microchip That Can Detect Type and Severity of Cancer Created Alzheimer's Researcher Demonstrates Specific Immune Response to Vaccine How Stem Cells Make Skin Genes Identified may Help Breast Cancer Diagnosis New Role of Vitamin C in Skin Protection Key Protein Controlling Brain Formation Identified Master Gene that Switches on Disease-Fighting Cells Identified by Scientists Why Don't Brain Tumors Respond to Medication? Silenced Genes as Warning Sign of Blood Cancer Think Zinc: Molecular Sensor Could Reveal Zinc's Role in Diseases Parkinson's Disease: When Cells Run Out of Fuel Switching on the Power of Stem Cells Watching Stem Cells Repair the Human Brain Nano-Magnets Guide Stem Cells to Damaged Tissue Scarring Key to Link Between Obesity and Diabetes Researchers Successfully Reverse Multiple Sclerosis in Animals Viral Mimic Induces Melanoma Cells to Digest Themselves Cancer Cells Are Protected by Our Own Immune System Researchers Learn How Blood Cells 'Talk' Stem Cell 'Daughters' Lead to Breast Cancer Discovery of a Mechanism Controlling the Fate of Hematopoietic Stem Cells Placenta-Derived Stem Cells May Help Sufferers of Lung Diseases Critical Link in Cell Death Pathway Revealed Researchers Discover Genetic Circuit That Regulates Behavior of Stem Cells Asperger Syndrome, Autism, and Empathy: Study Links 27 Genes Stem Cells: Environmental Factors Instruct Lineage Choice of Blood Progenitor Cells Circulating Blood Cells are Important Predictors of Cancer Spread in Children Improving Mouse Heart Function Following Heart Attack New Weapon in the War Against HIV-AIDS: Combined Antiviral and Targeted Chemotherapy Cancer is Second Most Frequent Cause of Death in Individuals with Schizophrenia Synthetic Biology: Gene Therapy Gets Under the Skin Second Chance for Dangerous T-Cells How Cancers Spread to the Brain Health Risks of Nanotechnology: How Nanoparticles Can Cause Lung Damage and How the Damage Can Be Blocked Vaporized Viral Vector Shows Promise in Anti-Cancer Gene Therapy New Way to Enhance Stem Cells to Stimulate Muscle Regeneration Fruit Fly Stem Cells Filmed Live Revolutionary Ultrasonic Nanotechnology May Allow Scientists to See Inside Patient’s Individual Cells World First: Chinese Scientists Create Pluripotent Stem Cells from Pigs Model for New Generation of Blood Vessels Challenged Non-Wovens as Scaffolds for Artificial Tissue Bone Marrow Stem Cell Co-Transplantation Prevents Embryonic Stem Cell Transplant-Associated Tumors Cancer: Detecting, Targeting, and Disabling Tumor Cells, All in One Step White Blood Cells Can Sprout 'Legs' and Move like Millipedes Bones Made from Human Skin Connective Tissue Potential Preventative Therapy for Type 1 Diabetes Upside-Down World: DNA Protecting Protein Helps Cancer Drug to Kill Cells Stem Cell Focus for IBD Wound Healing Diabetes: MicroRNA Protects Beta Cells Human Stem Cells Promote Healing of Diabetic Ulcers Learning Disabilities in Males: Nine New X Chromosome Genes Linked to Learning Disabilities Stem Cell Therapy Grows New Blood Vessels Scientists Synthesize Gold to Shed Light on Cells' Inner Workings Large Quantity of Stem Cells Produced from Small Number of Blood Stem Cells Common Virus Kills Cancer Stem Cells Researchers Reveal How Immune Cells Can Be Harnessed to Target Melanoma Geologist’s Research Could Provide Breakthrough for Heart Patients Regulatory Molecule for Tumor Formation or Suppression Identified Dendritic Cells Ensure Immune Tolerance Experts Use Nanotech to Deliver Anti-Cancer Genes Stem-Cell Repair Kit for Stroke Secrets of C. Difficile's Protective Shell Revealed Viscosity Changes in Cancer Cells Studied The Making of an Intestinal Stem Cell Tiny Tool to Control Growing Blood Vessels Opens New Potential in Tumor Research A Stem Cell Bandage for Your Knee An Inexhaustible Source of Neural Cells Study: Cell Injections Accelerate Fracture Healing New Genes Involved in Acute Lymphoblastic Leukemia Play Fundamental Role in Prognosis of the Disease Adult Stem Cells Convert Into Embryonic-like Stem Cells, With Single Factor 'Nonsense' in Our Genes: One in 200 Human Genes Superfluous? Surgical Implants Coated with One of 'Nature's Antibiotics' Could Prevent Infection Advancement in Tissue Engineering Promotes Oral Wound Healing Stem Cells Used to Reverse Paralysis in Animals How Cancer Cells Survive a Chemotherapy Drug Inflammation Worsens Danger Due to Atherosclerosis Scientists Successfully Develop Novel Biomaterial to Help Grow New Blood Vessels New Mechanism Regulates Type I Interferon Production in White Blood Cells Bone Marrow Stem Cells Used to Regenerate Skin Scientists Call Up Stem Cell Troops to Repair the Body Using New Drug Treatments Older Women Who Are More Physically Fit Have Better Cognitive Function Key to Future Medical Breakthroughs is Systems Biology, Say Leading European Scientists Brain Birth Defects Successfully Reversed Through Stem Cell Therapy Breakthrough in Understanding Development of Type 1 Diabetes Heart Regenerates After Infarction -- First Trials with Mice Type 1 Diabetes and Celiac Disease Linked Gene May Make Kids Crave Junk Food Between Dormancy and Self-Renewal: Mouse Model Shows Blood Stem Cells in Action New Targeted Fluorescent-Imaging Compound Allows Researchers to Detect Viable Cancer Cells in Mice Dormant Stem Cells for Emergencies Stem Cell Research Hold Great Promise, but Obstacles Remain, Expert Argues The Light Syringe Portuguese Scientists Discover New Mechanism that Regulates Formation of Blood Vessels Immune Cells Reveal Fancy Footwork New Approach Keeps Tumor Cells from Refueling Pure Insulin-Producing Cells Produced in Mice Neurons Derived from Embryonic Stem Cells Restore Muscle Function After Injury Adult Stem Cell Breakthrough: First Tissue-Engineered Trachea Successfully Transplanted Pfizer Launches Global Regenerative Medicine Research Unit A New Laser Technique Seals and Heals Wounds Jumonjd3: A Key for Unlocking Neuronal Stem Cell Fate Intraspinal Implant of Mesenchymal Stem Cells May Not Heal the Demyelinated Spinal Cord Heartbeat Supplements Power to Run Implanted Medical Devices Umbilical Cord Blood May Help Build New Heart Valves Completely Novel Action of Insulin Unveiled Skin Cancer: Designer Molecule Tackles Malignant Cells by Two Completely Different Routes Stem Cell Therapies for Heart Disease – One Step Closer Singapore Develops Cell Therapy Treatment for Cancer New Artificial Heart in Preclinical Testing in Europe Cold Virus Found to Manipulate Genes Scientists Trigger Cancer-like Response from Embryonic Stem Cells New Properties of Skin Stem Cells Breast Stem Cell Fate is Regulated by 'Notch' A Key Mechanism Regulating Neural Stem Cell Development is Uncovered Stem Cells From the Testicle: True Alternative to Embryonic Stem Cells Cornea Uses Stem Cells to Repair Itself Scientists Identify New Bone Protecting Protein Treating Vitiligo With a New Cell Therapy Scientists Identify for the First Time the Genes that Cause Blindness Produced by Corneal Oedema New Site Launched for Families and Scientists to Discuss Stem Cell Research Human Embryonic Stem Cell Secretions Minimized Tissue Injury After Heart Attack Gene Expression Profile Shared by Pluripotent Stem Cells Found New Stem Cell Screening Tool Takes Adult Stem Cell Research to New Level Stem Cell Research Compares Methods of Creating Patient-Specific Stem Cells Scientists Reveal Changes to Embryonic Stem Cells Caused by Down Syndrome New Stem Cell Tools to Aid Drug Development Researchers Replicate Insulin-Producing Cells, Providing New Hope for Diabetics New Discovery About Growth Factor can be Breakthrough for Cancer Research Blood Vessel Cells are Instructed to Form Tube-Like Structures Animal Testing Could Soon Be a Thing of the Past Cells in Eye Could Help Control Sleep Trial: Tumor Regressions Achieved in Relapsed Lymphoma Patients Potential New Treatment for Alzheimer’s Disease Robot with a Biological Brain: New Research Provides Insights into How the Brain Works SickKids Scientists Uncover the Key to Controlling How Stem Cells Develop Building the Bionic Body Human Embryonic Stem Cells Developed from 4-Cell Embryo--World First May Lessen Ethical Concerns Bath Researchers Study How Cancer Cells Come Unstuck Why Gene Therapy Caused Leukemia in Some "Boy in the Bubble Syndrome" Patients Sugar Study is Sweetener for Stem Cell Science Insulin-Producing Cells Can Give Rise to Stem-Like Cells In-Vitro Standards in Stem Cell Research New Approach to Cancer: Find Most Tightly Controlled Genes Genetic Variation Increases HIV Risk in People of African Descent Genetic Profiling for Breast Cancer on the Horizon “Doughnuts” Deliver Drugs Stem Cell Therapies Offer Patients Hope and Reduced Health Care Costs Measuring the Footprint of Cells Adult Stem Cell Findings Offer New Hope for Parkinson's Cure Inhalable Form of Gene Therapy Takes Aim at Lung Cancer and Inflammatory Lung Disease Gene Therapy Involving Antibiotics May Help Patients With Usher Syndrome Discovery of New Family of Genetic Mutations Involved in Inflammatory Intestinal Disease Rapid Wound Healing With Dressing Made of Silica Gel Fibers Saving Teeth by Using Periodontal Ligament Regeneration Mapping of Prostate Cancer Genes Opens the Door to New Treatments Vancouver Researchers Pioneer Safe Pathway to Slow ALS Using Stem Cells Bone Repair Using Patient's Own Stem Cells Transfusable Blood From Stem Cells Pioneering Induction of Bone Formation Using Embryonic Stem Cells Muscle-Derived Stem Cells Prove Effective in Repairing Sphincter Damage to Restore Continence Discovery May Reverse/Prevent Cognitive Decline That Occurs During Ageing Dementia Genes Linked to Osteoporosis Identified Stem Cell Type Supposed to be Crucial for Angiogenesis and Cancer Growth Does Not Exist Cancer Cells Spread by Releasing 'Bubbles', According to New Study Tiny Magnets Used in Anti-Cancer Gene Therapy Stem Cell Hope for Fixing Injured Knees Clearer Day for Gene Therapy: New Vector Carries Big Genes Linked to Inherited Blindness Manchester University Announces Stem Cell Breakthrough New Venture for Therapy with Cord Blood and Adult Stem Cells World-First Stem Cell Screening Facility to Target Brain Tumors Way to Target Genes Devised for Gene Therapy Stem Cell Funding for Parkinson’s Disease Stem Cell Breakthrough Offers Diabetes Hope Scottish Consortium to Start Work on 3D Cell-Based Assay Post Brain Injury: New Nerve Cells Originate From Neural Stem Cells Lifetime Probability of Needing a Stem Cell Transplant is Much Higher Than Previously Reported Deep-Brain Stimulation for Alzheimer’s Patients Considered Cheek Swab Kits Successful in Recruiting Bone Marrow Donors Breakthrough Technique Restores Light Sensitivity in Damaged Retinas Monash Pioneers Nano Scaffold to Rebuild Nerve Damage Stem Cell Therapy Trials to Mend Shattered Bones Coming Soon Patient Gets New Jaw Cultivated From Own Stem Cells Atlantic Veterinary College: New Technology Heals Horses Faster, Stronger Imitating Monkeys Jumping Genes Could Lead To New Treatments for HIV Human Clinical Trials of Stem Cell Treatment That Could Replace Bone Marrow Transplants New Acute Lung Injury Study Finds Benefits of Autologous Cell Transplantation Therapy Helmet Helps Alzheimer’s Patients Polymer Gel Prevents Skin Grafts from Shrinking 'Telepathic' Genes Recognize Similarities in Each Other Discovery: Mutations of a Part of the X Chromosome Lead to Mental Retardation Treatment for Brittle Bones Before Birth Twins Confirm the Beginning of Childhood Leukemia Macular Degeneration Stem Cell Therapy Repair May Be On the Horizon Lab-Grown Brain Cells Could Treat Parkinson’s Disease Gene Suppression Enhances Wound Healing Research on Treatments to Improve Muscle Loss Due to Disease and Aging Gene Therapy Experiences Another Setback in UK Growing Artificial Skin From Hair Roots Gene Therapy May Protect Against Alcoholism Regenerative Medicine Researchers Use Fat to Repair Breast Defects Following a Lumpectomy Regenerative Medicine Aid: New Ultrasound Device Determines Best Time for Skin Transplant Muscular Dystrophy May Be Helped Through Regenerative Medicine Therapy Face Transplant Patient Doing Well Today Regenerative Stem Cell Therapy Helps Memory New Source for Dopamine Cells May Help Those With Parkinson’s Disease Important Step in Development of Artificial Nerves via Regenerative Medicine Endometrial Regenerative Cells: New Adult Stem Cells for Regenerative Medicine Adult Stem Cell Product to be Tested in Regenerative Medicine Stroke Trial New Regenerative Medicine Stem Cell Treatment Reduces Amputations in Critical Limb Ischemia Using Stem Cells to Treat Damaged Eyes and a Rare Skin Disorder Regenerative Medicine Efforts Honored: 2007 Prix D’Excellence Award Inauguration of the Clinical Translation Unit Treatment of Vascular Risk Factors Slows Advance of Alzheimer’s Skin-Derived Stem Cells Repair Spinal Cord Injuries in Rats Gene Therapy in Rats Reduces Rheumatoid Arthritis Swelling Growing Heart Valves Novalung: Bridge to Lung Transplant Stem Cell Subtype Discovery Could Lead to Improved Bone Marrow Transplants Bone-Strengthening Drugs May Benefit Young Stem Cell Transplant Recipients "Off-the-Shelf" Skin Grafts Stem Cells Grow Kidneys in Mice New Source for Stem Cell Line One For the Road: An Alcoholic’s Last Shot? Discovery Could Lead to Regenerative Therapies for Muscular Disease Gene Therapy Works to Eradicate Bowel Cancer Cells Gene Therapy Trial for Treatment of Leber’s Congenital Amaurosis (LCA) Bone Marrow May Help With Future Male Fertility Treatments Stem Cell Treatment for Runners Stem Cell Treatment for Recently Diagnosed Type 1 Diabetics Liver Cells Grown From Cord Blood