Authors:
Shutao Wang, Dr., Hao Wang, Dr., Jing Jiao, Dr., Kuan-Ju Chen, Gwen E. Owens, Ken-ichiro Kamei, Dr., Jing Sun, Dr., David J. Sherman, Christian P. Behrenbruch, Prof., Hong Wu, Prof., Hsian-Rong Tseng, Prof.
Summary:
A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (anti-EpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cell-capture efficiency when employed to isolate viable cancer cells from whole-blood samples.
Source:
Angewandte Chemie International Edition; Vol. 48, Issue 47, 8970-8973 (10/21/09)