Through a global gene expression analysis (transcriptomic), researchers were able to find and confirm a genetic signature common to these genodermatoses in patients' cells: recessive dystrophic epidermolysis bullosa, Kindler syndrome and xeroderma pigmentosum. The profile targets cellular activation and alteration of the dermal microenvironment (lower layer of the skin) which could favor the progression of the disease, as well as skin cancer.
Recessive dystrophic epidermolysis bullosa and the Kindler syndrome are diseases that cause fragility of the skin, caused by mutations in essential genes to attach the two layers of the skin. Patients with these diseases suffer from chronic erosion and wounds on the skin and mucosa, which causes terrible scarring and metastatic squamous cell carcinoma to develop. On the other hand, xeroderma pigmentosum is a disease characterized by high sensitivity to ultraviolet light, due to a deficiency in the DNA repair mechanisms, meaning patients are 110,000 times more likely to develop skin cancer.
This study, recently published in the
British Journal of Dermatology, sheds light on the underlying molecular mechanisms of the diseases and presents new pharmacological targets that are useful for the treatment of associated effects. This possibility of treating patients therapeutically (for example, with drug repositioning) is a clinical priority in order to improve their quality of life.
Illustration: An alteration common to the three diseases of 227 genes was identified. Universidad Carlos III de Madrid.
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Universidad Carlos III de Madrid News Release (02/28/19)
Science Daily (03/04/19)
Abstract (British Journal of Dermatology, 2019.)