Authors:
Xiaofei Zhang, Federica Bertaso, Jong W Yoo, Karsten Baumgärtel, Sinead M Clancy, Van Lee, Cynthia Cienfuegos, Carly Wilmot, Jacqueline Avis, Truc Hunyh, Catherine Daguia, Christian Schmedt, Jeffrey Noebels, & Timothy Jegla
Summary:
We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2−/− (also known as Kcnh3−/−) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.
Source:
Nature Neuroscience; 13, 1056-1058 (08/01/10)