Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer

Authors: Gholamreza Tavoosidana, Gunnar Ronquist, Spyros Darmanis, Junhong Yan, Lena Carlsson, Di Wu, Tim Conze, Pia Ek, Axel Semjonow, Elke Eltze, Anders Larsson, Ulf D. Landegren, and Masood Kamali-Moghaddam


Prostasomes are microvesicles (mean diameter, 150 nm) that are produced and secreted by normal and malignant prostate acinar cells. It has been hypothesized that invasive growth of malignant prostate cells may cause these microvesicles, normally released into seminal fluid, to appear in interstitial space and therewith into peripheral circulation. The suitability of prostasomes as blood biomarkers in patients with prostate cancer was tested by using an expanded variant of the proximity ligation assay (PLA). We developed an extremely sensitive and specific assay (4PLA) for detection of complex target structures such as microvesicles in which the target is first captured via an immobilized antibody and subsequently detected by using four other antibodies with attached DNA strands. The requirement for coincident binding by five antibodies to generate an amplifiable reporter results in both increased specificity and sensitivity. The assay successfully detected significantly elevated levels of prostasomes in blood samples from patients with prostate cancer before radical prostatectomy, compared with controls and men with benign biopsy results. The medians for prostasome levels in blood plasma of patients with prostate cancer were 2.5 to sevenfold higher compared with control samples in two independent studies, and the assay also distinguished patients with high and medium prostatectomy Gleason scores (8/9 and 7, respectively) from those with low score (≤6), thus reflecting disease aggressiveness. This approach that enables detection of prostasomes in peripheral blood may be useful for early diagnosis and assessment of prognosis in organ-confined prostate cancer.

Source: Proceedings of the National Academy of Sciences of the United States of America; Vol. 108, No. 21, 8809-8814 (05/24/11)

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cellular and regional vulnerability of excitatory neurons to tau pathology Portraits of communication in neuronal networks Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny decision Identifying the pathways required for coping behaviours associated with sustained pain HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation Quantifying single-cell secretion in real time using resonant hyperspectral imaging Importin α5 regulates anxiety through MeCP2 and Sphingosine Kinase 1 Jamming of deformable polygons Relationships between indicators of cardiovascular disease and intensity of oil and natural gas activity in northeastern Colorado Multivariate computational analysis of gamma delta T cell inhibitory receptor signatures reveals the divergence of healthy and ART-suppressed HIV aging Tau monomer encodes strains Dual inhibition of the lactate transporters MCT1 and MCT4 is synthetic lethal with metformin due to NAD depletion in cancer cells Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic properties Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts Topography-driven surface renewal Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy Assembly of a pan-genome from deep sequencing of 910 humans of African descent Prion seeds distribute throughout the eyes of sporadic Creutzfeldt-Jakob disease patients Injectable macroporous hydrogel formed by enzymatic cross-linking of gelatin microgels Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery Large-scale preparation of extracellular vesicles enriched with specific microRNA Alginate-graphene oxide hydrogels with enhanced ionic tunability and chemomechanical stability for light-directed 3D printing Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model Genetic analysis reveals AMPK is required to support tumor growth in murine kras-dependent lung cancer models DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival Inhibition of amino acid metabolism selectively targets human leukemia stem cells Shape selective bifacial recognition of double helical DNA Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms Association of obesity subtypes in the longitudinal assessment of bariatric surgery study and 3‐year postoperative weight change Statins attenuate outgrowth of breast cancer metastases Magnetocardiography on an isolated animal heart with a room-temperature optically pumped magnetometer Mutational landscape of secondary glioblastoma guides MET-targeted trial in brain tumor Variation in TMEM106B in chronic traumatic encephalopathy A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy Antifibrotic synergy between phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators in Peyronie's Disease models Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a Evaluating the evidence on sitting, smoking, and health: is sitting really the new smoking? A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice Detailed visual cortical responses generated by retinal sheet transplants in rats with severe retinal degeneration The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease Antiphospholipid antibodies in patients with myocardial infarction Gut microbiota in the first 2 years of life and the association with body mass index at age 12 in a Norwegian birth cohort BacCapSeq: a platform for diagnosis and characterization of bacterial infections A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis Programmed assembly of synthetic protocells into thermoresponsive prototissues Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients The lineage-defining transcription factors SOX2 and NKX2-1 determine lung cancer cell fate and shape the tumor immune microenvironment Reservoir computing with a single delay-coupled non-linear mechanical oscillator Small-molecule-based regulation of RNA-delivered circuits in mammalian cells Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment Mammographic breast density assessment using deep learning: clinical implementation ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea Comparison of the performance of common measures of weight regain after bariatric surgery for association with clinical outcomes Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis Modeling and prediction of clinical symptom trajectories in Alzheimer’s disease using longitudinal data Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage Complement component C3 is highly expressed in human pancreatic islets and prevents β cell death via ATG16L1 interaction and autophagy regulation Conformational dynamics of the ABC transporter McjD seen by single‐molecule FRET Genome-wide identification of structure-forming repeats as principal sites of fork collapse upon ATR inhibition Electric field–induced release and measurement liquid biopsy for noninvasive early lung cancer assessment ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program Lifetime risk of common neurological diseases in the elderly population The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 Consumption of red and processed meat and breast cancer incidence: a systematic review and meta-analysis of prospective studies Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease Combination therapy with anti-HIV-1 antibodies maintains viral suppression Fisetin is a senotherapeutic that extends health and lifespan Biofabrication of autologous human hepatocytes for transplantation: how do we get there? Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells An inhibitor of GSK3B and HDACs kills pancreatic cancer cells and slows pancreatic tumor growth and metastasis in mice Brain endothelial erythrophagocytosis and hemoglobin transmigration across brain endothelium: implications for pathogenesis of cerebral microbleeds MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons Active wetting of epithelial tissues Aging suppresses skin-derived circulating SDF1 to promote full-thickness tissue regeneration Structure of the human epithelial sodium channel by cryo-electron microscopy Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016 Functional classification of long non-coding RNAs by k-mer content Serum biomarker signature-based liquid biopsy for diagnosis of early-stage pancreatic cancer Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose Membrane-induced hydroelastic migration of a particle surfing its own wave CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature MicroRNA-141-3p negatively modulates SDF-1 expression in age dependent pathophysiology of human and murine bone marrow stromal cells A high throughput screen for next-generation leads targeting malaria parasite transmission Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate Disease-associated short tandem repeats co-localize with chromatin domain boundaries Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration Susceptible period for cardiovascular complications in patients recovering from sepsis COMRADES determines in vivo RNA structures and interactions Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology Mood variations decoded from multi-site intracranial human brain activity A fluid-to-solid jamming transition underlies vertebrate body axis elongation In vivo reprogramming of wound-resident cells generates skin epithelial tissue Direct generation of human cortical organoids from primary cells Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer – the S.U.R.G.U.V.A.N.T. trial SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix Epistatic control of intrinsic resistance by virulence genes in Listeria Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction Visual rehabilitation training alters attentional networks in hemianopia: An fMRI study Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock Minimizing context dependency of gene networks using artificial cells Discovery of novel cell surface markers for purification of embryonic dopamine progenitors for transplantation in Parkinson’s disease animal models Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling Small molecules co-targeting CKIα and the transcriptional kinases CDK7/9 control AML in preclinical models Digitally tunable microfluidic bioprinting of multilayered cannular tissues County-level air quality and the prevalence of diagnosed chronic kidney disease in the US Medicare population The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort Intestinal metabolism and bioaccumulation of sucralose in adipose tissue in the rat Telomere shortening is a hallmark of genetic cardiomyopathies Association of variants in BAG3 with cardiomyopathy outcomes in African American individuals Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells Circulating tumor DNA measurements as early outcome predictors in diffuse large B-cell lymphoma A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT) Correlation between polar surface area and bioferroelectricity in DNA and RNA nucleobases Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector Progressive massive fibrosis resurgence identified in U.S. coal miners filing for black lung benefits, 1970–2016 Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems Huntingtin aggregation impairs autophagy, leading to Argonaute-2 accumulation and global microRNA dysregulation A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells KIM-1 as a blood-based marker for early detection of kidney cancer: a prospective nested case-control study Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors Dysregulation in actin cytoskeletal organization drives increased stiffness and migratory persistence in polyploidal giant cancer cells Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression Photochemical 'in-air' combinatorial discovery of antimicrobial copolymers Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer’s disease Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders Effect of platelet-rich plasma on chondrogenic differentiation of adipose- and bone marrow-derived mesenchymal stem cells Stretchable, implantable, nanostructured flow-diverter system for quantification of intra-aneurysmal hemodynamics Impact of edible cricket consumption on gut microbiota in healthy adults, a double-blind, randomized crossover trial Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion Optical imaging of metabolic dynamics in animals Evaluation of a novel rule-out myocardial infarction protocol incorporating high-sensitivity troponin T in a US hospital Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells 18F-fluoroestradiol tumor uptake is heterogeneous and influenced by site of metastasis in breast cancer patients Hematopoietic cell-derived RELMα regulates hookworm immunity through effects on macrophages Prioritizing the needs of children in a changing climate Kinetic basis for DNA target specificity of CRISPR-Cas12a Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease Magnetic drug targeting: a novel treatment for intramedullary spinal cord tumors Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation A three-dimensional human neural cell culture model of Alzheimer's disease A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures Gene exchange drives the ecological success of a multi-host bacterial pathogen Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory Topical curcumin nanocarriers are neuroprotective in eye disease Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3 Ex vivo biomechanical characterization of syringe-needle ejections for intracerebral cell delivery Compressed collagen enhances stem cell therapy for corneal scarring Human limbal biopsy-derived stromal stem cells prevent corneal scarring Concise review: stem cells in the corneal stroma Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis Smart surgical catheter for c-reactive protein sensing based on an imperceptible organic transistor Human pluripotent reprogramming with CRISPR activators Smart bandage for monitoring and treatment of chronic wounds Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma Anti-tumour necrosis factor therapy for Dupuytren's disease: a randomised dose response proof of concept phase 2a clinical trial Thermal proteome profiling in bacteria: probing protein state in vivo Ras and rap signal bidirectional synaptic plasticity via distinct subcellular microdomains DNA-induced liquid phase condensation of cGAS activates innate immune signaling Unique Francisella phosphatidylethanolamine acts as a potent anti-inflammatory lipid Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein Discovery of UDP-glycosyltransferases and BAHD-acyltransferases involved in the biosynthesis of the anti-diabetic plant metabolite montbretin Changes in pain intensity following discontinuation of long-term opioid therapy for chronic non-cancer pain Sampling molecular conformations and dynamics in a multiuser virtual reality framework Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program Continuous biomarker monitoring by particle mobility sensing with single molecule resolution Control of spreading depression with electrical fields Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates Costs and benefits of provocation in bacterial warfare Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation A Ca2 -stimulated exosome release pathway in cancer cells is regulated by Munc13-4 Multiscale analysis of independent Alzheimer’s cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus Locally coordinated synaptic plasticity of visual cortex neurons in vivo Resistance to enediyne antitumor antibiotics by sequestration Newfound effect of N -acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro How diverse retinal functions arise from feedback at the first visual synapse Precision therapeutic targeting of human cancer cell motility A naturally occurring antiviral ribonucleotide encoded by the human genome Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism Therapeutic luminal coating of the intestine Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes BAFF neutralization aggravates atherosclerosis Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis Hippocampal calcifications: risk factors and association with cognitive function α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease Human plasma and serum extracellular small RNA reference profiles and their clinical utility Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension Cost-effectiveness analysis of biopsy strategies for endometrial cancer diagnosis in women with postmenopausal bleeding: Pipelle sampling curette versus dilatation & curettage Gestational changes in buprenorphine exposure: a physiologically based pharmacokinetic analysis Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis Clinical trials in a dish: a perspective on the coming revolution in drug development Ultra-protective mechanical ventilation without extra-corporeal carbon dioxide removal for acute respiratory distress syndrome Testosterone is an endogenous regulator of BAFF and splenic B cell number Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps BigSCale: an analytical framework for big-scale single-cell data Computationally identified novel agonists for GPRC6A Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer Extracellular matrix-based materials for regenerative medicine Assessment of follow-up care after emergency department presentation for mild traumatic brain injury and concussion: results from the TRACK-TBI study A randomized trial of a family-support intervention in intensive care units Restoring vision Expanded autologous regulatory T-lymphocyte infusions in ALS A causal mechanism for childhood acute lymphoblastic leukaemia Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response Xenoprotein engineering via synthetic libraries Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria 3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk Analysis of red blood cell partitioning at bifurcations in simulated microvascular networks Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults Microfluidics-enabled multimaterial maskless stereolithographic bioprinting Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development Procalcitonin-guided use of antibiotics for lower respiratory tract infection Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen S-nitrosylation of β-arrestins biases receptor signaling and confers ligand independence Spatial mutation patterns as markers of early colorectal tumor cell mobility Staphylococcus aureus utilizes host-derived lipoprotein particles as sources of fatty acids Sheathless inertial cell focusing and sorting with serial reverse wavy channel structures Benefits and safety of dietary protein for bone health—an expert consensus paper endorsed by the European Society for Clinical and Economical Aspects of Osteopororosis, Osteoarthritis, and Musculoskeletal Diseases and by the International Osteoporos Dual-wavelength 3D photoacoustic imaging of mammalian cells using a photoswitchable phytochrome reporter protein Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis Have we made progress with educational services for students with TBI NDF, a nucleosome destabilizing factor that facilitates transcription through nucleosomes Sharpening of hierarchical visual feature representations of blurred images Human gut microbiota predicts susceptibility to Vibrio cholera infection Negative feedback phosphorylation of Gγ subunit Ste18 and the Ste5 scaffold synergistically regulates MAPK activation in yeast Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region Bone marrow is a major parasite reservoir in Plasmodium vivax infection Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis TAR DNA-binding protein 43 and disrupted in schizophrenia 1 coaggregation disrupts dendritic local translation and mental function in frontotemporal lobar degeneration Coarse particulate matter (PM2.5–10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning Validating the concept of mutational signatures with isogenic cell models Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling Impact of healthy lifestyle factors on life expectancies in the US population Enzymatic or in vivo installation of propargyl groups in combination with click chemistry for the enrichment and detection of methyltransferase target sites in RNA Oral administration and detection of a near-infrared molecular imaging agent in an orthotopic mouse model for breast cancer screening Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP PS1 double transgenic rat model of Alzheimer’s disease DNA methylation and regulatory elements during chicken germline stem cell differentiation Spatial heterogeneity and evolutionary dynamics modulate time to recurrence in continuous and adaptive cancer therapies Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices Precise multimodal optical control of neural ensemble activity Shared strategies for β-lactam catabolism in the soil microbiome Radiomic features on MRI enable risk categorization of prostate cancer patients on active surveillance: preliminary findings Training a cell-level classifier for detecting basal-cell carcinoma by combining human visual attention maps with low-level handcrafted features A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis Long ncRNA A-ROD activates its target gene DKK1 at its release from chromatin Proton-pump inhibitors and long-term risk of community-acquired pneumonia in older adults A new method for the high-precision assessment of tumor changes in response to treatment Cardiac mTORC1 dysregulation impacts stress adaptation and survival in Huntington's disease Drought-sensitivity of fine dust in the U.S. Southwest: Implications for air quality and public health under future climate change Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases Neuropsychological predictors of long-term (10 years) mild cognitive impairment stability Age is relative—impact of donor age on induced pluripotent stem cell-derived cell functionality An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design Neoadjuvant PD-1 blockade in resectable lung cancer High-speed live-cell interferometry: a new method for quantifying tumor drug resistance and heterogeneity The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis An in vivo model of functional and vascularized human brain organoids A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M diffuse midline gliomas Risk and prognosis of cancer after lower limb arterial thrombosis The dynamics of concussion: mapping pathophysiology, persistence, and recovery with causal-loop diagramming Artificial intelligence estimation of carotid-femoral pulse wave velocity using carotid waveform Use of antiepileptic drugs and dementia risk-an analysis of Finnish health register and German health insurance data Highly scalable generation of DNA methylation profiles in singles cells Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector Hemodynamic forces tune the arrest, adhesion, and extravasation of circulating tumor cells Adipocyte p62/SQSTM1 suppresses tumorigenesis through opposite regulations of metabolism in adipose tissue and tumor Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars Machine learning detects pan-cancer ras pathway activation in The Cancer Genome Atlas State estimation for a penicillin fed-batch process combining particle filtering methods with online and time delayed offline measurements Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency Proprioceptive and cutaneous sensations in humans elicited by intracortical microstimulation Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding APC inhibits ligand-independent Wnt signaling by the clathrin endocytic pathway Evaluation of 1C-Me-NB1 as a potential PET radioligand for measuring GluN2B-containing NMDA receptors, drug occupancy, and receptor cross talk A global transcriptional network connecting noncoding mutations to changes in tumor gene expression Nanoengineered injectable hydrogels for wound healing application MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis Transcatheter laceration of aortic leaflets to prevent coronary obstruction during transcatheter aortic valve replacement Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adults Complete biosynthesis of noscapine and halogenated alkaloids in yeast Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat Large volume syringe pump extruder for desktop 3D printers Referral regions for time-sensitive acute care conditions in the United States Genome-wide somatic variant calling using localized colored de Bruijn graphs Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus Mutations in PMPCB encoding the catalytic subunit of the mitochondrial presequence protease cause neurodegeneration in early childhood Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in vitro and in vivo Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids Suppression of diabetes by accumulation of non-islet-specific CD8 effector T cells in pancreatic islets Thyroid disrupting chemicals and brain development: an update Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction Reconfigurable paramagnetic microswimmers: Brownian motion affects non-reciprocal actuation A bit-encoding based new data structure for time and memory efficient handling of spike times in an electrophysiological setup Dynamic protein assembly by programmable DNA strand displacement Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration Intracranial metastasis in fibrolamellar hepatocellular carcinoma Genetically encoded lipid–polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans Linear assembly of a human centromere on the Y chromosome Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation Capture Hi-C identifies putative target genes at 33 breast cancer risk loci Mid-infrared imaging in breast cancer tissue: an objective measure of grading breast cancer biopsies Antibiotic-induced population fluctuations and stochastic clearance of bacteria Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells A breathing atom-transfer radical polymerization: fully oxygen-tolerant polymerization inspired by aerobic respiration of cells Solid-phase synthesis of protein-polymers on reversible immobilization supports Learning by neural reassociation Balanced crystalloids versus saline in noncritically ill adults 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses Skin electronics from scalable fabrication of an intrinsically stretchable transistor array C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor Sexual dimorphism in the behavioral responses and the immuno-endocrine status in D-galactose induced aging Cognitive functioning after hematopoietic cell transplantation for hematologic malignancy: results from a prospective longitudinal study Association of epidural stimulation with cardiovascular function in an individual with spinal cord injury RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumor growth Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription A vitamin B12 conjugate of Exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles The polyploid state plays a tumor-suppressive role in the liver Rehealable, fully recyclable, and malleable electronic skin enabled by dynamic covalent thermoset nanocomposite Intra-atrial dyssynchrony during sinus rhythm predicts recurrence after the first catheter ablation for atrial fibrillation Positively selected enhancer elements endow osteosarcoma cells with metastatic competence Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects Ribosome incorporation into somatic cells promotes lineage transdifferentiation towards multipotency Ibrutinib inhibition of ERBB4 reduces cell growth in a WNT5A-dependent manner Cataract in patients with diabetes mellitus—incidence rates in the UK and risk factors Bioresorbable optical fiber Bragg gratings Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics Differential association of microvascular attributions with cardiovascular disease in patients with long duration of type 1 diabetes In vivo wireless photonic photodynamic therapy Relaxin reverses inflammatory and immune signals in aged hearts Mimicking embedded vasculature structure for 3D cancer on a chip approaches through micromilling De novoexpression of human polypeptideN-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium Chromosomal instability during neurogenesis in Huntington's disease Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: Implications for PD-1-targeted therapy Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes Structures of human PRC2 with its cofactors AEBP2 and JARID2 Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy Sensitization of hypoxic tumors to radiation therapy using ultrasound sensitive oxygen microbubbles Tumor-specific T-Cells engineered to overcome tumor immune evasion induce clinical responses in patients with relapsed Hodgkin lymphoma Safety and efficacy of immunotherapy with the recombinant B-cell epitope–based grass pollen vaccine BM32 Primary cilium-mediated retinal pigment epithelium maturation is disrupted in ciliopathy patient cells Removal of oral biofilm on an implant fixture by a cavitating jet Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework Detection and localization of surgically resectable cancers with a multi-analyte blood test Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay Loss of an androgen-inactivating and isoform-specific HSD17B4 splice form enables emergence of castration-resistant prostate cancer Co-activation of GR and PPARγ in murine skin prevents worsening of atopic march Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling Genomic and proteomic resolution of heterochromatin and its restriction of alternate fate genes Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning Polygenic contribution in individuals with early-onset coronary artery disease Multi-day rhythms modulate seizure risk in epilepsy Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice Reprogramming the activatable peptide display function of adeno-associated virus nanoparticles Hedgehog pathway drives fusion-negative rhabdomyosarcoma initiated from non-myogenic endothelial progenitors Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia Glial responses to implanted electrodes in the brain Enhancing recovery from sepsis, a review Endogenous reprogramming of alpha cells into beta cells, induced by viral gene therapy, reverses autoimmune diabetes Reversible retinal vessel closure from VEGF-induced leukocyte plugging A tunable microfluidic 3D stenosis model to study leukocyte-endothelial interactions in atherosclerosis Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer Programmed platelet derived growth factor‐bb and bone morphogenetic protein‐2 delivery from a hybrid calcium phosphate/alginate scaffold Modern therapeutic approaches for noninfectious ocular diseases involving inflammation TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis Food-grade cationic antimicrobial ε-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice Interferon-beta represses cancer stem cell properties in triple-negative breast cancer EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer Substrate-driven chemotactic assembly in an enzyme cascade The Std1 activator of the Snf1/AMPK kinase controls glucose response in yeast by a regulated protein aggregation Direct electrical stimulation of the amygdala enhances declarative memory in humans The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer Efficacy of educational video game versus traditional educational apps at improving physician decision making in trauma triage: randomized controlled trial Effect of high-intensity treadmill exercise on motor symptoms in patients with de novo Parkinson disease: a phase 2 randomized clinical trial Injecting instructions into premotor cortex Simple detection of telomere fusions in pancreatic cancer, intraductal papillary mucinous neoplasm, and pancreatic cyst fluid Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus Efficient protein production by yeast requires global tuning of metabolism Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis Runx3 programs CD8 T cell residency in non-lymphoid tissues and tumours mTORC2 promotes tumorigenesis via lipid synthesis Do viruses exchange genes across superkingdoms of life? Second-degree burns with six etiologies treated with autologous noncultured cell-spray grafting Nitro-oleic acid (NO2OA) release enhances regional angiogenesis in a rat abdominal wall defect model Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structure A melanin-mediated cancer immunotherapy patch TDP-43 accelerates age-dependent degeneration of interneurons Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors Thermostable exoshells fold and stabilize recombinant proteins Nonimmune cells equipped with T-cell-receptorlike signaling for cancer cell ablation Inhibition of TRF1 telomere protein impairs tumor initiation and progression in glioblastoma mouse models and patient-derived xenografts ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing Inflammation-induced IgA cells dismantle anti-liver cancer immunity BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy Single-cell virology: on-chip investigation of viral infection dynamics Near-infrared remotely triggered drug-release strategies for cancer treatment Regeneration of the entire human epidermis using transgenic stem cells Clinical decision support for in-hospital AKI Understanding tissue-specific gene regulation Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands Virtual reality improves embodiment and neuropathic pain caused by spinal cord injury Long term effect of intensive lifestyle intervention on cerebral blood flow Modulation of inflammation in brain: a matter of fat Synthetic beta cells for fusion-mediated dynamic insulin secretion Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson Disease Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo Transcription factor ISX mediates the cross talk between diet and immunity PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction Synergistic malaria vaccine combinations identified by systematic antigen screening Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy Isolation of exosomes from whole blood by integrating acoustics and microfluidics Validation of a metastatic assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets Synthetic hydrogels for human intestinal organoid generation and colonic wound repair Novel nanoparticles with Cr3 substituted ferrite for self-regulating temperature hyperthermia PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals Genetic effects on gene expression across human tissues Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data Sensitivity to BUB1B inhibition defines an alternative classification of glioblastoma CCND2 overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes: remuscularization of injured ventricle A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells Bioinspired flexible microfluidic shear force sensor skin Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche Is abdominal hypopressive technique effective in the prevention and treatment of pelvic floor dysfunction? Marketing or evidence from high-quality clinical trials? Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma Determination of the impact of melanoma surgical timing on survival using the National Cancer Database Cbfβ governs osteoblast−adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm Induced pluripotent stem cell-derived neural stem cell therapy enhances recovery in an ischemic stroke pig model Tension creates an endoreplication wavefront that leads regeneration of epicardial tissue Effects of autogenous bone marrow aspirate concentrate on radiographic integration of femoral condylar osteochondral allografts Prevention of Alzheimer's Disease: lessons learned and applied Chemical modulation of in vivo macrophage function with subpopulation-specific fluorescent prodrug conjugates Prostaglandin E1 and its analog misoprostol inhibit human CML stem cell self-renewal via EP4 receptor activation and repression of AP-1 A novel neural prediction error found in anterior cingulate cortex ensembles O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking Deletion of interleukin 1 receptor-associated kinase 1 (Irak1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle Model-based design of RNA hybridization networks implemented in living cells Mechanistic investigation of the specific anticancer property of artemisinin and its combination with aminolevulinic acid for enhanced anticolorectal cancer activity A recombinant human ADAMTS-13: first-in-human study evaluating pharmacokinetics, safety and tolerability in cTTP patients A cargo-sorting DNA robot A predictive model for selective targeting of the Warburg Effect through GAPDH inhibition with a natural product Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells Locally induced adipose tissue browning by microneedle patch for obesity treatment Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans Shape-specific nanoceria mitigate oxidative stress-induced calcification in primary human valvular interstitial cell culture In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis Tau exacerbates excitotoxic brain damage in an animal model of stroke Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration A functional genomics predictive network model identifies regulators of inflammatory bowel disease High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling The burden and etiology of diarrheal illness in developing countries Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2 Human plasma metabolomics study across all stages of age-related macular degeneration identifies potential lipid biomarkers Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease LMO1 synergizes with MYCN to promote neuroblastoma initiation and metastasis Signals from the adipose microenvironment and the obesity–cancer link—a systematic review Pharmacological inhibition of the DNA damage checkpoint prevents radiation-induced oocyte death Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms The deacetylase HDAC6 mediates endogenous neuritic tau pathology Synthetic quorum sensing in model microcapsule colonies Microbial regulation of microRNA expression in the amygdala and prefrontal cortex Peripherally derived FGF21 promotes remyelination in the central nervous system Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis Feeding releases endogenous opioids in humans Anti-inflammatory therapy with canakinumab for atherosclerotic disease Stimulation of functional neuronal regeneration from Müller glia in adult mice Microglia turnover with aging and in an Alzheimer´s model via long-term in vivo single-cell imaging Prolonged human neural stem cell maturation supports recovery in injured rodent CNS Proteasome activity regulates CD8 T lymphocyte metabolism and fate specification Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche Neuroprotective effects of trigeminal nerve stimulation in severe traumatic brain injury Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells BACE inhibition-dependent repair of Alzheimer's pathophysiology Mesoscopic adaptive resolution scheme toward understanding of interactions between sickle cell fibers Transcriptomic biomarkers to discriminate bacterial from nonbacterial infection in adults hospitalized with respiratory illness Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy Cell segregation and border sharpening by Eph receptor–ephrin-mediated heterotypic repulsion Computational integration of nanoscale physical biomarkers and cognitive assessments for Alzheimer’s disease diagnosis and prognosis The role of retinal carotenoids and age on neuroelectric indices of attentional control among early to middle-aged adults Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: an alternative concept in reconstruction of spinal cord circuits Necroptosis activation in Alzheimer's disease Functional annotation of chemical libraries across diverse biological processes Inverted battery design as ion generator for interfacing with biosystems Genome editing abrogates angiogenesis in vivo Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish Triggerable tough hydrogels for gastric resident dosage forms Synthetic quorum sensing in model microcapsule colonies Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease Comparison of algorithms for the detection of cancer drivers at subgene resolution Deformation correction for image-guided liver surgery: An intraoperative assessment of fidelity Dll4 and Notch signalling couples sprouting angiogenesis and artery formation Transancestral mapping and genetic load in systemic lupus erythematosus Prosthetic valve endocarditis after surgical aortic valve replacement Dynamic responses of the adrenal steroidogenic regulatory network Infant gut microbiome associated with cognitive development Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction RNA stores tau reversibly in complex coacervates Comparison of the VA and NIDILRR TBI model system cohorts Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials Tumor-targeted and clearable human protein-based MRI nanoprobes Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis Recruitment of Epac2A to insulin granule docking sites regulates priming for exocytosis Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods Cellular prion protein (PrPC) in the development of Merlindeficient tumors High-speed and scalable whole-brain imaging in rodents and primates Nanonet force microscopy for measuring forces in single smooth muscle cells of the human aorta Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records Lutein exerts anti-inflammatory effects in patients with coronary artery disease Whole-body profiling of cancer metastasis with single-cell resolution Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility Inhibition of IKKɛ and TBK1 improves glucose control in a subset of patients with type 2 diabetes Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging Cell-cycle dynamics of chromosomal organization at single-cell resolution Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries An immunogenic personal neoantigen vaccine for patients with melanoma Direct imaging of protein stability and folding kinetics in hydrogels Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma Sculpting neurotransmission during synaptic development by 2D nanostructured interfaces A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay Selective optogenetic control of purkinje cells in monkey cerebellum Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock A calcium- and light-gated switch to induce gene expression in activated neurons Landscape of innovation for cardiovascular pharmaceuticals: from basic science to new molecular entities Adaptive capacity: an evolutionary neuroscience model linking exercise, cognition, and brain health Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts Zolpidem for the treatment of neurologic disorders: a systematic review Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices Left ventricular dysfunction switches mesenchymal stromal cells toward an inflammatory phenotype and impairs their reparative properties via toll-like receptor-4 clinical perspective Ratchet-like polypeptide translocation mechanism of the AAA disaggregase Hsp104 Microbial genetic composition tunes host longevity Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite Three mutations switch H7N9 influenza to human-type receptor specificity Hypothalamic regulation of distinct adult neural stem cells and neurogenesis Tropism, intracerebral distribution, and transduction efficiency of HIV- and SIV-based lentiviral vectors after injection into the mouse brain: a qualitative and quantitative in vivo study Sequential self-assembly of DNA functionalized droplets Atopic dermatitis and risk of hypertension, type-2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project Pulsed cavitational ultrasound softening Potent inhibitor of drug-resistant HIV-1 strains identified from the medicinal plant Justicia gendarussa A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs Drag reducing polymers decrease hepatic injury and metastases after liver ischemia-reperfusion Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia A novel strategy to engineer pre-vascularized full-length dental pulp-like tissue constructs Polarity of varicosity initiation in central neuron mechanosensation Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study A scalable platform to identify fungal secondary metabolites and their gene clusters Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis ACK1/TNK2 regulates histone H4 Tyr88-phosphorylation and AR gene expression in castration-resistant prostate cancer A systems biology approach identifies FUT8 as a driver of melanoma metastasis Impact of vitamin A and carotenoids on the risk of tuberculosis progression Obesity accelerates Alzheimer-related pathology in APOE4 but not APOE3 mice Tactile defensiveness and impaired adaptation of neuronal activity in the Fmr1 knockout mouse model of autism Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis Perirhinal firing patterns are sustained across large spatial segments of the task environment Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation JunB is essential for IL-23-dependent pathogenicity of Th17 cells Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta-analysis Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia Protein-free formation of bone-like apatite: New insights into the key role of carbonation GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer Specification and diversification of pericytes and smooth muscle cells from mesenchymoangioblasts Contralesional brain–computer interface control of a powered exoskeleton for motor recovery in chronic stroke survivors Use of a pedicled omental flap to reduce inflammation and vascularize an abdominal wall patch Endothelial TLR4 and the microbiome drive cerebral cavernous malformations Mutant KRAS promotes malignant pleural effusion formation Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation TIAM1 variants improve clinical outcome in neuroblastoma Quantitative erythrocyte omega-3 EPA plus DHA levels are related to higher regional cerebral blood flow on brain SPECT Targeting latency-associated peptide promotes antitumor immunity Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition Maintenance of persistent activity in a frontal thalamocortical loop The complex genetics of hypoplastic left heart syndrome Compositional changes in the gut mucus microbiota precede the onset of colitis-induced inflammation The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication Outcomes of patients with double-hit lymphoma who achieve first complete remission A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis Evaluating the safety of β-interferons in MS Humoral immune reconstitution kinetics following allogeneic hematopoietic stem cell transplantation in children: a maturation block of IgM memory B cells may lead to impaired antibody immune reconstitution Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases Topical delivery of anti-VEGF drugs to the ocular posterior segment using cell-penetrating peptides The single-parameter, structure-based IsoPSA assay demonstrates improved diagnostic accuracy for detection of any prostate cancer and high-grade prostate cancer compared to a concentration-based assay of total prostate-specific antigen Photosensitization priming of tumor microenvironments improves delivery of nanotherapeutics via neutrophil infiltration Identification of targetable ALK rearrangements in pancreatic ductal adenocarcinoma Impact of genomic profiling on the treatment and outcomes of patients with advanced gastrointestinal malignancies Platelets subvert T cell immunity against cancer via GARP-TGFβ axis Meeting report for NIH 2016 progenitor cell biology consortium cardiovascular tissue engineering 2016 Signalome-wide assessment of host cell response to hepatitis C virus Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survival High-throughput, low-loss, low-cost, and label-free cell separation using electrophysiology-activated cell enrichment Identification of cardiac hemo-vascular precursors and their requirement of sphingosine-1-phosphate receptor 1 for heart development County-level cumulative environmental quality associated with cancer incidence CHD4 has oncogenic functions in initiating and maintaining epigenetic suppression of multiple tumor suppressor genes Red blood cells for glucose-responsive insulin delivery Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice Population-based stroke and dementia incidence trends: age and sex variations Interaction of 12/15 lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved post-myocardial infarction healing Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy Brd4 modulates the innate immune response through Mnk2–eIF4E pathway-dependent translational control of IκBα The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP) Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models MicroRNA-210 enhances fibrous cap stability in advanced atherosclerotic lesions novelty and significance Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila Trial of transplantation of HCV-infected kidneys into uninfected recipients MAN2A1–FER fusion gene is expressed by human liver and other tumor types and has oncogenic activity in mice Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene Data-driven modeling for precision medicine in pediatric acute liver failure Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control Differentiation of V2a interneurons from human pluripotent stem cells Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells iPSC-derived human microglia-like cells to study neurological diseases Ultrafast laser-probing spectroscopy for studying molecular structure of protein aggregates Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer Access granted: iRGD helps silicasome-encased drugs breach the tumor barrier PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8 T cells Detection of interferon alpha protein reveals differential levels and cellular sources in disease IL-36γ signaling controls the induced regulatory T cell–Th9 cell balance via NFκB activation and STAT transcription factors mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert) HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert Dynamic range adaptation in primary motor cortical populations In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia Report on the National Eye Institute audacious goals initiative: replacement of retinal ganglion cells from endogenous cell sources Increasing efficiency of preclinical research by group sequential designs Technology versus biology: the limits of pre‐implantation genetic screening Early-life antibiotic treatment enhances the pathogenicity of CD4 T cells during intestinal inflammation Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44 Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits The burden of neurological disease in the United States: a summary report and call to action ANGPTL3 deficiency and protection against coronary artery disease CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells In vitro and in vivo evaluation of a novel integrated wearable artificial lung Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer’s-like impairment in mice Confined space facilitates G-quadruplex formation Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix Reduced DNA methylation and psychopathology following endogenous hypercortisolism – a genome-wide study Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection Rehabilitation for people living with dementia: A practical framework of positive support Microscopic characterization of the Brazilian giant samba virus Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle Therapy of primary and metastatic liver cancer by human iPS cell-derived myeloid cells producing interferon-β Proteogenomic integration reveals therapeutic targets in breast cancer xenografts Inflammation boosts bacteriophage transfer between Salmonella spp. Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer Germline mutations in the Kallikrein 6 region and predisposition for aggressive prostate cancer Randomized trial of a hypofractionated radiation regimen for the treatment of localized prostate cancer Stable and potent selenomab-drug conjugates Electroacupuncture promotes CNS-dependent release of mesenchymal stem cells Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation An adipo-biliary-uridine axis that regulates energy homeostasis Structure of the active form of human origin recognition complex and its ATPase motor module Reduced regional grey matter volumes in pediatric obstructive sleep apnea Eosinophils are key regulators of perivascular adipose tissue and vascular functionality Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol Safety observations with three years of denosumab exposure: comparison between subjects who received denosumab during the randomized FREEDOM trial and subjects who crossed over to denosumab during the FREEDOM extension Targeting glutamate signalling in depression: progress and prospects A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism Piloting a remission strategy in type 2 diabetes: results of a randomized controlled trial Vision loss after intravitreal injection of autologous “stem cells” for AMD Structural basis of substrate recognition by the multidrug resistance protein MRP1 Systematic mapping of RNA-chromatin interactions in vivo Tracking the fate and origin of clinically relevant adoptively transferred CD8 T cells in vivo The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis Dietary prebiotics and bioactive milk fractions improve NREM sleep, enhance REM sleep rebound and attenuate the stress-induced decrease in diurnal temperature and gut microbial alpha diversity Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: a combined neutron scattering and MD simulation study Analysis of the T cell response to Zika virus and identification of a novel CD8 T cell epitope in immunocompetent mice Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas Abnormal capillary vasodynamics contribute to ictal neurodegeneration in epilepsy Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes Low serum vitamin D during remission increases risk of clinical relapse in patients with ulcerative colitis Transient auditory nerve demyelination as a new mechanism for hidden hearing loss Correlation of long-term results of imatinib in advanced gastrointestinal stromal tumors with next-generation sequencing results A macrophage relay for long-distance signaling during postembryonic tissue remodeling Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration RUNX1 cooperates with FLT3-ITD to induce leukemia Mining the human gut microbiota for immunomodulatory organisms Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine Harnessing catalytic pumps for directional delivery of microparticles in microchambers Macromolecularly “caged” carbon nanoparticles for intracellular trafficking via switchable photoluminescence A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline Neuronal activity in ontogeny and oncology The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein Perturbations of the anti-ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria Perinatal nicotine exposure impairs the maturation of glutamatergic inputs in the auditory brainstem Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2 Synchrotron x-ray fluorescence nanoprobe reveals target sites for organo-osmium complex in human ovarian cancer cells Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function A rapid screening method to evaluate the impact of nanoparticles on macrophages Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist IL-27 limits type 2 immunopathology following parainfluenza virus infection MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy Chemopreventive potential of in vitro fermented nuts in LT97 colon adenoma and primary epithelial colon cells Comparative effectiveness of vancomycin and metronidazole for the prevention of recurrence and death in patients with Clostridium difficile infection Alterations in the gut microbiota can elicit hypertension in rats Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c External size but not aBMD predicts structural and mass changes for women transitioning through menopause Experimental measurement of binding energy, selectivity, and allostery using fluctuation theorems Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms A non-canonical mismatch repair pathway in prokaryotes Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams Wall teichoic acids mediate increased virulence in Staphylococcus aureus Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2 Data-driven modeling for precision medicine in pediatric acute liver failure Noninvasive targeted transcranial neuromodulation via focused ultrasound gated drug release from nanoemulsions Hysterectomy-corrected cervical cancer mortality rates reveal a larger racial disparity in the United States Nutritional considerations for healthy aging and reduction in age-related chronic disease Cryoelectron microscopy maps of human papillomavirus 16 reveal l2 densities and heparin binding site Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes An extended fatty liver index to predict non-alcoholic fatty liver disease Micromotors spontaneously neutralize gastric acid for pH-responsive payload release Zika virus disrupts molecular fingerprinting of human neurospheres 3D bioprinting of functional human skin: production and in vivo analysis Post-Ebola reforms: ample analysis, inadequate action Hyperspectral phasor analysis enables multiplexed 5D in vivo imaging IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma The descending diencephalic dopamine system is tuned to sensory stimuli Sleepiness and sleep-related breathing disorders in myotonic dystrophy and responses to treatment: a prospective cohort study Health-care-associated infections in neonates, children, and adolescents: an analysis of paediatric data from the European Centre for Disease Prevention and Control point-prevalence survey Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells Prevention of dietary-fat-fueled ketogenesis attenuates BRAF V600E tumor growth The ubiquitin ligase Smurf1 functions in selective autophagy of mycobacterium tuberculosis and anti-tuberculous host defense Flavivirus infection uncouples translation suppression from cellular stress responses A comparison of surrogate endpoints for all cause mortality in men with localized unfavorable-risk prostate cancer Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemia Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation Insights into the mechanistic basis of plasmid-mediated colistin resistance from crystal structures of the catalytic domain of MCR-1 Biomarker signatures of aging Modular immune organoids with integrin ligand specificity differentially regulate ex vivo B cell activation MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress Detection of viral RNA in tissues following plasma clearance from an Ebola virus infected patient Acute plasma tau relates to prolonged return to play after concussion GelMA encapsulated hDPSCs and HUVECs for dental pulp regeneration Whole genome relationships among Francisella bacteria of diverse origin define new species and provide specific regions for detection Nonsteroidal anti-inflammatory drugs and endometrial carcinoma mortality and recurrence Vav proteins are key regulators of Card9 signaling for innate antifungal immunity Cancer cell hyperactivity and membrane dipolarity monitoring via raman mapping of interfaced graphene: toward non-invasive cancer diagnostics Electrically oscillating plasmonic nanoparticles for enhanced DNA vaccination against hepatitis C virus Mechanisms of bacterial persistence during stress and antibiotic exposure Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence Protective immunity elicited by oral immunization of mice with salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) mutants Influence of donor age on induced pluripotent stem cells Free serum hemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis Clonal variation in drug and radiation response among glioma-initiating cells is linked to proneural-mesenchymal transition A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice Sex and race differences in the association between statin use and the incidence of Alzheimer disease NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update 2016 Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity Intrinsic subtype switching and acquired ERBB2/HER2 amplifications and mutations in breast cancer brain metastases Redefining the invertebrate RNA virosphere 5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE2 Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11 eEF2K/eEF2 pathway controls the excitation/inhibition balance and susceptibility to epileptic seizures Obesity: fermentable carbohydrates increase satiety signals 3D-CLEM reveals that a major portion of mitotic chromosomes is not chromatin Chronology of onset of mental disorders and physical diseases in mental-physical comorbidity - a national representative survey of adolescents Structure of a human astrovirus capsid - antibody complex and mechanistic insights into virus neutralization Synthetic recording and in situ readout of lineage information in single cells Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer Fear reduction without fear through reinforcement of neural activity that bypasses conscious exposure A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood Association of 3 different antihypertensive medications with hip and pelvic fracture risk in older adults: secondary analysis of a randomized clinical trial Relationship of lutein and zeaxanthin levels to neurocognitive functioning: an fMRI study of older adults p15 expression differentiates nevus from melanoma Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy ChromoplecticTPM3–ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis Proteomic profiling reveals a specific role for translesion DNA polymerase η in the alternative lengthening of telomeres Structural analysis of X-Linked Retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function Functional and genomic architecture of Borrelia burgdorferi-induced cytokine responses in humans Systemic therapy for previously untreated advanced BRAF-mutated melanoma Neuroplasticity following anterior cruciate ligament injury: a framework for visual-motor training approaches in rehabilitation Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology Genome dynamics and molecular infection epidemiology of multi-drug resistant Helicobacter pullorum isolates obtained from broiler and country chickens in India Next-generation sequencing diagnostics of bacteremia in septic patients Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model Kidney function after the first kidney stone event Oxidative guanine base damage regulates human telomerase activity The spatial structure of correlated neuronal variability A topical mitochondria-targeted redox cycling nitroxide mitigates oxidative stress induced skin damage Sensory dynamics of visual hallucinations in the normal population Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration Statements of agreement from the targeted evaluation and active management (TEAM) approaches to treating concussion meeting held in Pittsburgh, October 15-16, 2015 Inflammation following traumatic brain injury in humans: insights from data-driven and mechanistic models into survival and death Characterisation of a flavonoid ligand of the fungal protein Alt a 1 NAD replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair Prospective longitudinal analysis of 2-hydroxyglutarate magnetic resonance spectroscopy identifies broad clinical utility for the management of patients with IDH-mutant glioma Pharmacologic activation of estrogen receptor increases mitochondrial function, energy expenditure, and brown adipose tissue Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis Association between androgen deprivation therapy and risk of dementia Molecular classification of Crohn's disease reveals two clinically relevant subtypes Evolution of protein phosphorylation across 18 fungal species Sustained virologic control in SIV macaques following short term ART and 47-mAb treatment Is a normal TSH synonymous with “euthyroidism” in levothyroxine monotherapy? Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms Neuropeptide Y as a biomarker and therapeutic target for neuroblastoma Defective transcytosis of APP and lipoproteins in human iPSC-derived neurons with familial Alzheimer’s disease mutations Validation of a clinical-grade assay to measure donor-derived cell-free DNA in solid organ transplant recipients Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection Stretchable materials for robust soft actuators towards assistive wearable devices Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: 10‐year follow‐up of the Multi‐Ethnic Study of Atherosclerosis (MESA) The p53 pathway controls SOX2-mediated reprogramming in the adult mouse spinal cord Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development Circulating CXCR5 PD-1 ICOS follicular T helper cells are increased close to the diagnosis of type 1 diabetes in children with multiple autoantibodies The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials The potential health effects of dietary phytoestrogens Brain Modulyzer: interactive visual analysis of functional brain connectivity An excitatory cortical feedback loop gates retinal wave transmission in rodent thalamus Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry Maternal milk T cells drive development of transgenerational Th1 immunity in offspring thymus Motor cortex activity predicts response alternation during sensorimotor decisions Cosmic radiation exposure and persistent cognitive dysfunction Intracortical microstimulation of human somatosensory cortex Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2 A LRRK2-dependent EndophilinA phosphoswitch is critical for macroautophagy at presynaptic terminals Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity Probiotics, fiber and herbal medicinal products for functional and inflammatory bowel disorders Context processing and the neurobiology of post-traumatic stress disorder The structure of the antibiotic deactivating,N-hydroxylating Rifampicin Monooxygenase Mechanism of Rifampicin inactivation in Nocardia farcinica Extensive migration of young neurons into the infant human frontal lobe The calcium channel subunit alpha2delta2 suppresses axon regeneration in the adult CNS Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis Single-molecule imaging reveals that Rad4 employs a dynamic DNA damage recognition process Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically Spermidine suppresses age-associated memory impairment by preventing adverse increase of presynaptic active zone size and release 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers Lack of P4H-TM in mice results in age-related retinal and renal alterations Chemotherapy-induced IL-34 enhances immunosuppression by tumor-associated macrophages and mediates survival of chemoresistant lung cancer cells TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity Autocrine BDNF–TrkB signalling within a single dendritic spine Mycoplasma pneumoniaetriggering the Guillain-Barré syndrome: A case-control study Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 A resolution Preventative vaccines for Zika virus outbreak: preliminary evaluation Biomechanical and biochemical characterization of porcine tracheal cartilage Stimulation-based control of dynamic brain networks Discovery of a metastatic immune escape mechanism initiated by the loss of expression of the tumor biomarker interleukin-33 A global genetic interaction network maps a wiring diagram of cellular function The impact of endurance training on human skeletal muscle memory, global isoform expression and novel transcripts Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation Bacteriome and mycobiome interactions underscore microbial dysbiosis in familial Crohn’s disease Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin Functional subclone profiling for prediction of treatment-induced intra-tumor population shifts and discovery of rational drug combinations in human glioblastoma Clinical outcomes of melanoma brain metastases treated with stereotactic radiosurgery and anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy Leisure-time physical activity and the risk of suspected bacterial infections Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts Single-cell characterization of viral translation-competent reservoirs in HIV-infected individuals Integrative modeling reveals Annexin A2-mediated epigenetic control of mesenchymal glioblastoma Sertraline for preventing mood disorders following traumatic brain injury Beyond Krabbe's disease: The potential contribution of galactosylceramidase deficiency to neuronal vulnerability in late-onset synucleinopathies Bruton tyrosine kinase-dependent immune cell cross-talk drives pancreas cancer Macrophage PI3K drives pancreatic ductal adenocarcinoma progression PI3Kγ is a molecular switch that controls immune suppression Effects of abaloparatide-sc on fractures and bone mineral density in subgroups of postmenopausal women with osteoporosis and varying baseline risk factors Development of a three-dimensional bioengineering technology to generate lung tissue for personalized disease modeling Epigenome wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction Effect of wearable technology combined with a lifestyle intervention on long-term weight loss: the IDEA randomized clinical trial Suppressor of cytokine signaling-1 (SOCS1) peptidomimetic limits progression of diabetic nephropathy Midlife physical activity and cognition later in life: a prospective twin study Detection of therapeutically targetable driver and resistance mutations in lung cancer patients by next generation sequencing of cell-free circulating tumor DNA Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling Identification of altered metabolomic profiles following a Panchakarma-based Ayurvedic intervention in healthy subjects: the self-directed biological transformation initiative (SBTI) Mutational signatures of ionizing radiation in second malignancies Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing Single-molecule dissection of stacking forces in DNA Prefrontal responses to Stroop tasks in subjects with post-traumatic stress disorder assessed by functional near infrared spectroscopy Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser Synaptic mechanisms of pattern completion in the hippocampal CA3 network On-target efficacy of a HIF2α antagonist in preclinical kidney cancer models 3D porous graphene by low-temperature plasma welding for bone implants Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ)... PRC2 enacts Wnt signaling in intestinal homeostasis and contributes to the instigation of stemness in diseases entailing epithelial hyperplasia or neoplasia The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer Gut bacteria metabolism impacts immune recovery in HIV-infected individuals Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness Pattern recognition with “materials that compute” CRISPR-Cas9 nuclear dynamics and target recognition in living cells Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38 Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies A randomized, double-blind, placebo-controlled trial of low-dose sertraline in young children with fragile X syndrome Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis Low adoption of weight loss medications: A comparison of prescribing patterns of antiobesity pharmacotherapies and SGLT2s Patient attitudes toward telemedicine for diabetic retinopathy Recent evolution of the salivary mucin MUC7 Multi-organ mapping of cancer risk Altered proliferation and networks in neural cells derived from idiopathic autistic individuals Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomized, double-blind, placebo-controlled trial Relationship between antihypertensive medications and cognitive impairment: part II. review of physiology and animal studies Short term depression of gap junctional coupling in reticular thalamic neurons of absence epileptic rats IL-1β is an innate immune sensor of microbial proteolysis Genetic markers of pigmentation are novel risk loci for uveal melanoma Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis Cell boundary elongation by non-autonomous contractility in cell oscillation Cellular resolution circuit mapping in mouse brain with temporal-focused excitation of soma-targeted channelrhodopsin Complete unique genome sequence, expression profile, and salivary gland tissue tropism of the herpesvirus 7 homolog in pigtailed macaques Biophysical insight into mechanisms of sonoporation Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumor hypoxic regions Targeted epigenetic remodeling of endogenous loci by CRISPR/Cas9-based transcriptional activators directly converts fibroblasts to neuronal cells Punctuated copy number evolution and clonal stasis in triple-negative breast cancer Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function Risk and impact of pulmonary complications in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2 channel–vesicle coupling Neurometabolic disorders: potentially treatable abnormalities in patients with treatment-refractory depression and suicidal behavior Stromal Hedgehog signaling is downregulated in colon cancer and its restoration restrains tumor growth Neurons in macaque area V4 are tuned for complex spatio-temporal patterns A conserved microRNA regulatory circuit is differentially controlled during limb/appendage regeneration Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients The airway microbiome at birth Global distribution of businesses marketing stem cell-based interventions The evolution of epigenetics: from prokaryotes to humans and its biological consequences A dual molecular analogue tuner for dissecting protein function in mammalian cells Olfactory receptors modulate physiological processes in human airway smooth muscle cells OCT4 acts as an integrator of pluripotency and signal-induced differentiation The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction Curcumin sensitizes silymarin to exert synergistic anticancer activity in colon cancer cells Age-dependent niche signals from the choroid plexus regulate adult neural stem cells The macroecology of infectious diseases: a new perspective on global-scale drivers of pathogen distributions and impacts An integrated genomic and transcriptomic survey of mucormycosis-causing fungi A network of conserved synthetic lethal interactions for exploration of precision cancer therapy Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity The rhesus monkey connectome predicts disrupted functional networks resulting from pharmacogenetic inactivation of the amygdala Spatial embedding and wiring cost constrain the functional layout of the cortical network of rodents and primates Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism Comparison of ACC/AHA and ESC guideline recommendations following trial evidence for statin use in primary prevention of cardiovascular disease--results from the population-based rotterdam study Matrix-bound nanovesicles within ECM bioscaffolds Impact of volume change over time on trauma mortality in the United States Intra-tumor heterogeneity affects gene expression profile test prognostic risk stratification in early breast cancer An acellular biologic scaffold treatment for volumetric muscle loss: results of a 13-patient cohort study ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression Valproic acid induces antimicrobial compound production in doratomyces microspores Automatic segmentation of Drosophila neural compartments using GAL4 expression data reveals novel visual pathways Heart failure after myocardial infarction is associated with increased risk of cancer In vivo bioorthogonal chemistry enables local hydrogel and systemic pro-drug to treat soft tissue sarcoma Design of a genetically stable high fidelity coxsackievirus B3 polymerase that attenuates virus growth in vivo Gray matter maturation and cognition in children with different APOEε genotypes An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation Extra-coding RNAs regulate neuronal DNA methylation dynamics The mitochondrial unfoldase-peptidase complex ClpXP controls bioenergetics stress and metastasis Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition Adaptive randomization of veliparib–carboplatin treatment in breast cancer Adaptive randomization of neratinib in early breast cancer Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse Pittsburgh Compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European Memory Clinic study Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4•4 million participants DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury Defining the clonal dynamics leading to mouse skin tumor initiation Prevention of carcinogen-induced oral cancer by sulforaphane Does the cancer risk in colonic polyps unsuitable for polypectomy support the need for advanced endoscopic resections? Kataegis expression signature in breast cancer is associated with late onset, better prognosis, and higher HER2 levels Identification of lesion subtypes in biopsies of ductal carcinoma in situ of the breast using biomarker ratio imaging microscopy Visualization and analysis of gene expression in tissue sections by spatial transcriptomics Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine A powerful CRISPR/Cas9-based method for targeted transcriptional activation Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease Pathology of congenital Zika syndrome in Brazil: a case series Electrical stimulation of visual cortex can immediately improve spatial vision Machine perfusion of donor livers for transplantation: a proposal for standardized nomenclature and reporting guidelines Longitudinal analysis of patient-reported outcomes and cosmesis in a randomized trial of conventionally fractionated versus hypofractionated whole-breast irradiation MetaFast: fast reference-free graph-based comparison of shotgun metagenomic data Hydroxyapatite coating on PEEK implants: biomechanical and histological study in a rabbit model Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability An engineered switch in T cell receptor specificity leads to an unusual but functional binding geometry Cost-effectiveness of percutaneous closure of the left atrial appendage in atrial fibrillation based on results from PROTECT AF versus PREVAIL Association of the extent of resection with survival in glioblastoma Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly Superresolution imaging reveals nanometer- and micrometer-scale spatial distributions of T-cell receptors in lymph nodes Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic Tumour resistance in induced pluripotent stem cells derived from naked mole-rats Insulin-like growth factor-1 receptor deficiency in macrophages accelerates atherosclerosis and induces an unstable plaque phenotype in apolipoprotein E–deficient mice The development of spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) during gastric repair is absent in the aged stomach Microgeographic proteomic networks of the human colonic mucosa and their association with inflammatory bowel disease Acrolein is a pathogenic mediator of alcoholic liver disease and the scavenger hydralazine is protective in mice Shape transitions and chiral symmetry breaking in the energy landscape of the mitotic chromosome Reversal of cognitive decline in Alzheimer's disease Clinical outcomes of transplanted modified bone marrow-derived mesenchymal stem cells in stroke: a phase 1/2a study α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomized controlled trial Development and validation of endovascular chemotherapy filter device for removing high-dose doxorubicin: preclinical study Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia EGFR signal-network reconstruction demonstrates metabolic crosstalk in EMT Human glia can both induce and rescue aspects of disease phenotype in Huntington disease The risk of cancer with the use of recombinant human bone morphogenetic protein in spine fusion Inflammasome-dependent induction of adaptive NK cell memory Executive functioning and diabetes: The role of anxious arousal and inflammation An E3-ligase-based method for ablating inhibitory synapses Surgical therapies and tissue engineering: at the intersection between innovation and regulation Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus A diet mimicking fasting promotes regeneration and reduces autoimmunity and Multiple Sclerosis symptoms Enhanced sympathetic nerve activity induced by neonatal colon inflammation induces gastric hypersensitivity and anxiety-like behavior in adult rats Microbiota-derived phenylacetylglutamine associates with overall mortality and cardiovascular disease in patients with CKD Dysregulation of RBFOX2 is an early event in cardiac pathogenesis of diabetes A melanosomal two-pore sodium channel regulates pigmentation Evidence for the role of microRNA 374b in acquired cisplatin resistance in pancreatic cancer cells Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice A cholesterol-based allostery model of T cell receptor phosphorylation Zika virus infects human placental macrophages Simultaneous scalp, skull, kidney, and pancreas transplant from a single donor Na+ influx induced by new antimalarials causes rapid alterations in the cholesterol content and morphology of Plasmodium falciparum A neuronal culture system to detect prion synaptotoxicity Neuronal hyperactivity disturbs ATP microgradients, impairs microglial motility, and reduces phagocytic receptor expression triggering apoptosis/microglial phagocytosis uncoupling Additional measurement of hCG distinguishes physiological high-normal thyroid function and reveals large differences in the risk of developing preeclampsia Atrial arrhythmias after lung transplantation: Incidence and risk factors in 652 lung transplant recipients A new method for preparing mesenchymal stem cells and labeling with Ferumoxytol for cell tracking by MRI Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged ≥75 years Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple-negative breast cancer Medical device approvals through the premarket approval pathway in obstetrics and gynecology from 2000 to 2015 Development of a 3D printed, bioengineered placenta model to evaluate the role of trophoblast migration in preeclampsia Metabolic engineering of light-driven cytochrome P450 dependent pathways into Synechocystis sp. PCC 6803 The preventability of cancer: stacking the deck Preventable incidence and mortality of carcinoma associated with lifestyle factors among white adults in the United States A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus Visual impairment and blindness in adults in the United States Utilizing the dog genome in the search for novel candidate genes involved in glioma development—genome wide association mapping followed by targeted massive parallel sequencing identifies a strongly associated locus Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape Sitagliptin versus placebo in the treatment of nonalcoholic fatty liver disease: A randomized controlled trial High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study Greater hippocampal volume is associated with PTSD treatment response Fc-receptor polymorphisms, cetuximab therapy, and survival in the NCIC CTG CO.17 trial of colorectal cancer Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials Preliminary intraoperative validation of the nociception level index Pharmacogenetic discovery in CALGB (Alliance) 90401 and mechanistic validation of a VAC14 polymorphism that increases risk of docetaxel-induced neuropathy Subconcussive head trauma and near point of convergence Association of football subconcussive head impacts with ocular near point of convergence Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs Molecular mechanism of anesthetic-induced depression of myocardial contraction Adult NG2-glia are required for median eminence-mediated leptin sensing and body weight control Plasma biomarker analysis in pediatric ARDS: generating future framework from a pilot randomized control trial of methylprednisolone: a framework for identifying plasma biomarkers related to clinical outcomes in pediatric ARDS Apolipoprotein E4 causes age-dependent disruption of slow gamma oscillations during hippocampal sharp-wave ripples Simultaneous antibiofilm and antiviral activities of an engineered antimicrobial peptide during virus-bacterium coinfection Real-time quantification of single RNA translation dynamics in living cells DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity Developmental acquisition of regulomes underlies innate lymphoid cell functionality Climate change and the emergent epidemic of CKD from heat stress in rural communities: the case for heat stress nephropathy Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease Impact of maternal glucose and gestational weight gain on child obesity over the first decade of life in normal birth weight infants Higher C-reactive protein levels predict postoperative delirium in older patients undergoing major elective surgery: a longitudinal nested case-control study Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3 Rapid, low-cost detection of Zika virus using programmable biomolecular components Defects in neuromuscular transmission may underlie motor dysfunction in spinal and bulbar muscular atrophy Minihepcidin peptides as disease modifiers in mice affected by beta-thalassemia and polycythemia vera Evaluation of a portable artificial vision device among patients with low vision Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging The Clinical Research Office of the Endourological Society (CROES) multicentre randomised trial of narrow band imaging–assisted transurethral resection of bladder tumour (TURBT) versus conventional white light imaging–assisted TURBT in primary Slx5/Slx8 promotes replication stress tolerance by facilitating mitotic progression Chemical control of grafted human PSC-derived neurons in a mouse model of Parkinson’s Disease Sp7/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification Phenotypically distinct subtypes of psychosis accompany novel or rare variants in four different signaling genes Regulators of metastasis modulate the migratory response to cell contact under spatial confinement Factors associated with injurious falls in residential care facilities Prioritizing variants in complete hereditary breast and ovarian cancer (HBOC) genes in patients lacking known BRCA mutations A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer Optical fiber LPG biosensor integrated microfluidic chip for ultrasensitive glucose detection Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function Residential radon exposure and risk of incident hematologic malignancies in the Cancer Prevention Study-II Nutrition Cohort Tight junction protein 1 modulates proteasome capacity and proteasome inhibitor sensitivity in multiple myeloma via EGFR/JAK1/STAT3 signaling Predictive features of ligand-specific signaling through the estrogen receptor Interfacial geometry dictates cancer cell tumorigenicity NAD repletion improves mitochondrial and stem cell function and enhances lifespan in mice RNA splicing is a primary link between genetic variation and disease Regulators of metastasis modulate the migratory response to cell contact under spatial confinement Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model Minimally invasive screening for colitis using attenuated total internal reflectance fourier transform infrared spectroscopy Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV Development and validation of a new prognostic system for patients with hepatocellular carcinoma Fatty liver is an independent predictor of early carotid atherosclerosis From sample to multi-omics conclusions in under 48 hours Disentangling the association between statins, cholesterol, and colorectal cancer: a nested case-control study Limit cycle oscillations in standing human posture Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus Efficient total syntheses and biological activities of two teixobactin analogues Fracture healing: a consensus report from the International Osteoporosis Foundation Fracture Working Group Will they participate? predicting patients’ response to clinical trial invitations in a pediatric emergency department Intrauterine inflammation and maternal exposure to ambient PM2.5 during preconception and specific periods of pregnancy: the Boston birth cohort Twist1 induces distinct cell states depending on TGFBR1-activation Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity Bacterial superglue enables easy development of efficient virus-like particle based vaccines A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair Percutaneous lymphatic embolization of abnormal pulmonary lymphatic flow as treatment of plastic bronchitis in patients with congenital heart disease clinical perspective Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a Magnifying smartphone screen using Google glass for low-vision users Serum zinc concentration and C-reactive protein in individuals with human immunodeficiency virus infection: the positive living with HIV (POLH) study The molecular basis of the genesis of basal tone in internal anal sphincter The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells Primary prevention of cardiovascular disease in older adults Multiscale origami structures as interface for cells Competition between jagged-notch and endothelin1 signaling selectively restricts cartilage formation in the zebrafish upper face Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions Blue light reduces organ injury from ischemia and reperfusion Genetic lineage tracing identifies endocardial origin of liver vasculature Cholesterol analogs with degradation-resistant alkyl side chains are effective mycobacterium tuberculosis growth inhibitors Novel 3D magnetic resonance elastography for the noninvasive diagnosis of advanced fibrosis in NAFLD: a prospective study Population-based epidemiology and mortality of small malignant gastrointestinal stromal tumors in the USA Epidermal growth factor suppresses intestinal epithelial cell shedding via a MAPK dependent pathway Clinical exome sequencing in neurologic disease Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4•4 million participants SOD-mimetic M40403 is protective in cell and fly models of paraquat toxicity: implications for Parkinson disease Modulation of tissue repair by regeneration enhancer elements Cortical contributions to the auditory frequency-following response revealed by MEG Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization X-ray structures and mechanism of the human serotonin transporter Silicon nitride bioceramics induce chemically driven lysis in Porphyromonas gingivalis Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft TAM receptors regulate multiple features of microglial physiology Developing an animal model of Dupuytren’s disease by orthotopic transplantation of human fibroblasts into athymic rat Change in pain and physical function following bariatric surgery for severe obesity Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in anH19loss-of-imprinting mutant 3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: a novel class of potent tumor-selective cytotoxins Parameter selection and verification techniques based on global sensitivity analysis illustrated for an HIV model Role of p53, mitochondrial DNA deletions, and paternal age in autism: a case-control study Development of the Biopen: a handheld device for surgical printing of adipose stem cells at a chondral wound site Blocking synaptic removal of GluA2-containing AMPA receptors prevents the natural forgetting of long-term memories Steric trapping reveals a cooperativity network in the intramembrane protease GlpG Impact of prostate-specific antigen (PSA) screening trials and revised PSA screening guidelines on rates of prostate biopsy and postbiopsy complications Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation Voluntary imitation in Alzheimer’s disease patients Methionine and kynurenine activate oncogenic kinases in glioblastoma, and methionine deprivation compromises proliferation Type I bHLH proteins Daughterless and Tcf4 restrict neurite branching and synapse formation by repressing neurexin in postmitotic neurons Effective implementation of health information technologies in U.S. hospitals Hedgehog pathway inhibition Body temperature regulation in diabetes Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis Application of fluorescent protein expressing strains to evaluation of anti-tuberculosis therapeutic efficacy in vitro and in vivo Large-scale imaging of cortical dynamics during sensory perception and behavior Sequence features accurately predict genome-wide MeCP2 binding in vivo Frequency and complexity of de novo structural mutation in autism GABAergic neuron-specific loss of Ube3a causes angelman syndrome-like EEG abnormalities and enhances seizure susceptibility Leptin controls parasympathetic wiring of the pancreas during embryonic life Heterogeneity in Oct4 and Sox2 targets biases cell fate in 4-cell mouse embryos Lysosomal disorders drive susceptibility to tuberculosis by compromising macrophage migration Enhanced cancer immunotherapy by microneedle patch-assisted delivery of anti-PD1 antibody A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy A multicenter observational study of incretin-based drugs and heart failure Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection Staphylococcus aureus toxin potentiates opportunistic bacterial lung infections Primary cilium-autophagy-Nrf2 (PAN) axis activation commits human embryonic stem cells to a neuroectoderm fate Harnessing surface-bound enzymatic reactions to organize microcapsules in solution ECM hydrogel for the treatment of stroke: Characterization of the host cell infiltrate Integrative single-cell transcriptomics reveals molecular networks defining neuronal maturation during postnatal neurogenesis Gastric bypass surgery vs intensive lifestyle and medical intervention for type 2 diabetes: the CROSSROADS randomised controlled trial Ethnicity and prevalence of multiple sclerosis in east London Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury Ultrasensitive antibody detection by agglutination-PCR (ADAP) GT198 expression defines mutant tumor stroma in human breast cancer Spinal cord stimulation (SCS) and functional magnetic resonance imaging (fMRI): modulation of cortical connectivity with therapeutic SCS Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression Metagenomic sequencing with strain-level resolution implicates uropathogenic E. coli in necrotizing enterocolitis and mortality in preterm infants Diurnal salivary cortisol patterns prior to pregnancy predict infant birth weight Phase-selective entrainment of nonlinear oscillator ensembles Effects of oral contraceptive use on anterior cruciate ligament injury epidemiology Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation Preoperative prealbumin level as a risk factor for surgical site infection following elective spine surgery Mating-induced transcriptome changes in the reproductive tract of female Aedes aegypti The effect of treatment of obstructive sleep apnea on glycemic control in type 2 diabetes Structure- and function-based design of Plasmodium-selective proteasome inhibitors Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis A broad RNA virus survey reveals both miRNA dependence and functional sequestration Declining bowel cancer incidence and mortality in Germany—an analysis of time trends in the first ten years after the introduction of screening colonoscopy Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue Snoo and Dpp act as spatial and temporal regulators respectively of adult progenitor cells in the Drosophila trachea Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro Diagnostic screening for subclinical celiac disease using a rapid test in children aged 2–4 Individualized statin benefit for determining statin eligibility in the primary prevention of cardiovascular disease ACEMg diet supplement modifies progression of hereditary deafness Structural health monitoring (vibration) as a tool for identifying structural alterations of the lumbar spine: a twin control study Drug harms in the UK: a multicriteria decision analysis Longitudinal relationships between caloric expenditure and gray matter in the cardiovascular health study Incidence and risk factors for food hypersensitivity in UK infants: results from a birth cohort study Weekly vs. every-3-week paclitaxel and carboplatin for ovarian cancer Structural hot spots for the solubility of globular proteins NF-κB restricts inflammasome activation via elimination of damaged mitochondria Functional segregation of cortical regions underlying speech timing and articulation Age-dependent decrease of mitochondrial complex II activity in human skin fibroblasts Bariatric surgery and emergency department visits and hospitalizations for heart failure exacerbation Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloprotease-9 up-regulation in mice with painful peripheral neuropathy Hypothalamic leptin action is mediated by histone deacetylase 5 Targeting p38 or MK2 enhances the anti-leukemic activity of smac-mimetics Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination Anaplasmataceae-specific PCR for diagnosis and therapeutic guidance for symptomatic Neoehrlichiosis in immunocompetent host Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Prognostic impact of modulators of G proteins in circulating tumor cells from patients with metastatic colorectal cancer Skin redox balance maintenance: the need for an Nrf2-activator delivery system Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters Distinct structural pathways coordinate the activation of AMPA receptor-auxiliary subunit complexes Association between objectively measured physical activity and mortality in NHANES The BENEFIT trial: where do we go from here? Strong components of epigenetic memory in cultured human fibroblasts related to site of origin and donor age Positional proteomics reveals differences in N-terminal proteoform stability Structural and molecular basis for Ebola virus neutralization by protective human antibodies Protective monotherapy against lethal Ebola virus infection by a potent neutralizing antibody Metabolomics-based discovery of small molecule biomarkers in serum associated with dengue virus infections and disease outcomes Complete meiosis from embryonic stem cell-derived germ cells in vitro Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum Self-induced switchings between multiple space–time patterns on complex networks of excitable units A 3D bioprinting system to produce human-scale tissue constructs with structural integrity Convective flow reversal in self-powered enzyme micropumps The third international consensus definitions for sepsis and septic shock (sepsis-3) A framework for the development and interpretation of different sepsis definitions and clinical criteria Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome Dental pulp stem cells: a new cellular resource for corneal stromal regeneration Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo RNA hairpin folding in the crowded cell Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis The role of risk-reducing surgery in hereditary breast and ovarian cancer Effect of acetazolamide vs placebo on duration of invasive mechanical ventilation among patients with chronic obstructive pulmonary disease: a randomized clinical trial Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity Chronic ampakine treatments stimulate dendritic growth and promote learning in middle-aged rats Intracellular mGluR5 plays a critical role in neuropathic pain Collagen and heparan sulfate coatings differentially alter cell proliferation and attachment in vitro and in vivo MLL1 is essential for the senescence-associated secretory phenotype Rapid dry-reagent immunomagnetic biosensing platform based on volumetric detection of nanoparticles on 3D structures The kinetochore prevents centromere-proximal crossover recombination during meiosis Divergent associations of height with cardiometabolic disease and cancer: epidemiology, pathophysiology, and global implications Innate lymphoid cells are depleted irreversibly during acute HIV-1 infection in the absence of viral suppression Are the symptoms of calcific tendinitis due to neoinnervation and/or neovascularization? The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins Principles governing the self-assembly of coiled-coil protein nanoparticles 5-azacytidine enhances the mutagenesis of HIV-1 by reduction to 5-aza-2’-deoxycytidine Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1 Acute changes in striatal microstructure predict the development of interferon-alpha induced fatigue Highly robust crystalsome via directed polymer crystallization at curved liquid/liquid interface SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex Anthropogenic radio-frequency electromagnetic fields elicit neuropathic pain in an amputation model Neural bases of orthographic long-term memory and working memory in dysgraphia Understanding the association between chronic obstructive pulmonary disease and current anxiety: a population-based study Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice On-chip construction of liver lobule-like microtissue and its application for adverse drug reaction assay Non-catalytic roles for XPG with BRCA1 and BRCA2 in homologous recombination and genome stability Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the copper-chaperone-for-SOD Sustained Akt activity is required to maintain cell viability in seborrheic keratosis, a benign epithelial tumor Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells Life span extension by targeting a link between metabolism and histone acetylation in Drosophila Post-translational control of the temporal dynamics of transcription factor activity regulates neurogenesis High-resolution wavefront shaping with a photonic crystal fiber for multimode fiber imaging Novel Wnt regulator NEL-like molecule-1 antagonizes adipogenesis and augments osteogenesis induced by bone morphogenetic protein 2 Safety and efficacy of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia Differential toxicity of antibodies to the prion protein Trim28 haploinsufficiency triggers bi-stable epigenetic obesity Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans Spontaneous decoding of the timing and content of human object perception from cortical surface recordings reveals complementary information in the event-related potential and broadband spectral change Lipofilling of the breast does not increase the risk of recurrence of breast cancer An unprecedented mechanism of nucleotide methylation in organisms containing thyX Cell-type-specific control of brainstem locomotor circuits by basal ganglia Pathway-specific remodeling of thalamostriatal synapses in Parkinsonian mice Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2 DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer Computational modeling of oscillating fins that “catch and release” targeted nanoparticles in bilayer flows Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression ofCdkn2a Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis (IOTA) group Transcriptomic analysis of the host response and innate resilience to enterotoxigenic Escherichia coli infection in humans Bone microarchitecture in men and women with diabetes: the importance of cortical porosity Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes Association of asymptomatic bradycardia with incident cardiovascular disease and mortality: the multi-ethnic study of atherosclerosis (MESA) Plug-and-display: decoration of virus-like particles via isopeptide bonds for modular immunization Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2 Lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice Vitamin B12 status in older adults living in Ontario long-term care homes: prevalence and incidence of deficiency with supplementation as a protective factor COMT and OPRM1 genotype associations with daily knee pain variability and activity induced pain Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII Bioresorbable silicon electronic sensors for the brain Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance Functionalization of C(sp3)-H bonds using a transient directing group Reconfigurable chiroptical nanocomposites with chirality transfer from the macro- to the nanoscale Lysyl oxidase is associated with increased thrombosis and platelet reactivity WNT-SHH antagonism specifies and expands stem cells prior to niche formation Bicarbonate concentration, acid-base status, and mortality in the health, aging, and body composition study Local and global consequences of flow on bacterial quorum sensing High Kellgren-Lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing; the SEKOIA study Obesity-induced colorectal cancer is driven by caloric silencing of the guanylin-GUCY2C paracrine signaling axis TNF drives monocyte dysfunction with age and results in impaired anti-pneumococcal immunity Fiber and saturated fat are associated with sleep arousals and slow wave sleep Astrocytes assemble thalamocortical synapses by bridging NRX1α and NL1 via hevin AMP-activated protein kinase mediates mitochondrial fission in response to energy stress Functional reorganization and prediction of motor recovery after a stroke: A graph theoretical analysis of functional networks Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells Objectively-measured sedentary time and cardiometabolic health in adults with severe obesity Shared genetic predisposition in peripartum and dilated cardiomyopathies Secreted factors from human vestibular schwannomas can cause cochlear damage Proxy measures of vitamin D status – season and latitude – correlate with adverse outcomes after bariatric surgery in the Nationwide Inpatient Sample, 2001–2010: a retrospective cohort study Prevention of premature menopause and preservation of fertility in young cancer survivors: hopeful though modest long-term results Ovarian suppression with triptorelin during adjuvant breast cancer chemotherapy and long-term ovarian function, pregnancies, and disease-free survival: a randomized clinical trial Transient acute kidney injury in the postoperative period: it is time to pay closer attention Cardiovascular-specific mortality and kidney disease in patients undergoing vascular surgery In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity YAP is a critical inducer of SOCS3, preventing reactive astrogliosis Organic and inorganic mercurials have distinct effects on cellular thiols, metal homeostasis, and Fe-binding proteins in Escherichia coli Visualization of bacterial microcompartment facet assembly using high-speed atomic force microscopy Warning symptoms are associated with survival from sudden cardiac arrest In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer Abnormal cell-intrinsic and network excitability in the neocortex of serotonin-deficient Pet-1 knock-out mice Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA In vivo single-particle imaging of nuclear mRNA export in budding yeast demonstrates an essential role for Mex67p Patterns and functional implications of rare germline variants across 12 cancer types Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy Aerobic fitness in late adolescence and the risk of early death: a prospective cohort study of 1.3 million Swedish men Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins A fully human antibody to gp41 selectively eliminates HIV-infected cells that transmigrated across a model human blood brain barrier SerpinB1 promotes pancreatic β cell proliferation Electronic enhancement of tear secretion Analytic models of oxygen and nutrient diffusion, metabolism dynamics, and architecture optimization in three-dimensional tissue constructs with applications and insights in cerebral organoids Long-term outcome of a phase II trial using immunomodulatory in situ gene therapy in combination with intensity-modulated radiotherapy with or without hormonal therapy in the treatment of prostate cancer Dnmt3a2: a hub for enhancing cognitive functions Skeletal muscle and pediatric bone development A cellular system for spatial signal decoding in chemical gradients Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis A human 3′UTR clone collection to study post-transcriptional gene regulation Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas Valsartan/Sacubitril for heart failure reconciling disparities between preclinical and clinical investigations Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment Neuropathic ocular pain due to dry eye is associated with multiple comorbid chronic pain syndromes Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5 Subtle CXCR3-dependent chemotaxis of CTLs within infected tissue allows efficient target localization Oxygen enhanced MRI accurately identifies, quantifies, and maps hypoxia in preclinical cancer models Re-opening the critical window for estrogen therapy Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse PTH induces systemically administered mesenchymal stem cells to migrate to and regenerate spine injuries Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques Delayed rod-mediated dark adaptation is a functional biomarker for incident early age-related macular degeneration Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease Simultaneous reprogramming and gene correction of patient fibroblasts Human induced pluripotent stem cell–derived podocytes mature into vascularized glomeruli upon experimental transplantation rAAV-CFTRΔR rescues the cystic fibrosis phenotype in human intestinal organoids and CF mice Panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy The bioenergetic costs of a gene C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation Cell type–specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma Super natural killer cells that target metastases in the tumor draining lymph nodes Red blood cell dysfunction induced by high-fat diet Combining suppression of stemness with lineage-specific induction leads to conversion of pluripotent cells into functional neurons Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods Transcriptional landscape of cardiomyocyte maturation Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution Harnessing cellular-derived forces in self-assembled microtissues to control the synthesis and alignment of ECM Structural stability and local dynamics in disease-causing mutants of human apolipoprotein A-I: what makes the protein amyloidogenic? MicroRNA expression profiling of human blood monocyte subsets highlights functional differences RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics Mining retrospective data for virtual prospective drug repurposing: L-DOPA and age-related macular degeneration Unproven stem cell–based interventions and achieving a compromise policy among the multiple stakeholders A 3′ poly(A) tract is required for LINE-1 retrotransposition Dynamics of cell generation and turnover in the human heart No evidence for cardiomyocyte number expansion in preadolescent mice Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress Iroquois proteins promote skeletal joint formation by maintaining chondrocytes in an immature state Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence Rare variants in cardiomyopathy genes associated with stress-induced cardiomyopathy Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2 Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7 Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies Ultrasound ablation enhances drug accumulation and survival in mammary carcinoma models HIP1 is an early-stage prognostic biomarker of lung adenocarcinoma and suppresses metastasis via Akt-mediated EMT Efficient test and visualization of multi-set intersections Multiscale embedded gene co-expression network analysis Hydrogels with tunable stress relaxation regulate stem cell fate and activity Multinucleated giant cells are specialized for complement-mediated phagocytosis and large target destruction Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial Stimuli-responsive behavior of composites integrating thermo-responsive gels with photo-responsive fibers Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis A versatile microarray platform for capturing rare cells Long-term culture and expansion of primary human hepatocytes CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity The molecular karyotype of 25 clinical-grade human embryonic stem cell lines Human umbilical tissue-derived cells promote synapse formation and neurite outgrowth via thrombospondin family proteins Acquisition of portal venous circulating tumor cells from patients with pancreaticobiliary cancers by endoscopic ultrasound Intravenous multipotent adult progenitor cell treatment decreases inflammation leading to functional recovery following spinal cord injury Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade Chemical modifications mark alternatively spliced and uncapped messenger RNAs in arabidopsis New approaches to biological pacemakers: links to sinoatrial node development Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells Small cell lung cancer: recruitment of macrophages by circulating tumor cells Type 1 diabetes immunotherapy using polyclonal regulatory T cells Nucleosome stability distinguishes two different promoter types at all protein-coding genes in yeast New details of the human corneal limbus revealed with second harmonic generation imaging Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry Perforin-positive dendritic cells exhibit an immuno-regulatory role in metabolic syndrome and autoimmunity Distinct routes of lineage development reshape the human blood hierarchy across ontogeny Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling Invasive cell fate requires G1 cell-cycle arrest and histone deacetylase-mediated changes in gene expression The ecology of the microbiome: Networks, competition, and stability Noninvasive tracking of gene transcript and neuroprotection after gene therapy Cell-selective arrhythmia ablation for photomodulation of heart rhythm Lanosterol reverses protein aggregation in cataracts Pharmacological chaperone for α-crystallin partially restores transparency in cataract models A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder Pericytes are progenitors for coronary artery smooth muscle Atypical PKC-iota controls stem cell expansion via regulation of the Notch pathway Comparison of human embryonic stem cell-derived cardiomyocytes, cardiovascular progenitors, and bone marrow mononuclear cells for cardiac repair SoxC transcription factors are essential for the development of the inner ear Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss A pleiotropic RNA-binding protein controls distinct cell cycle checkpoints to drive resistance of p53-defective tumors to chemotherapy Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes Patrolling monocytes control tumor metastasis to the lung Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic Lupus Erythematosus mice and humans MSC transplantation improves osteopenia via epigenetic regulation of notch signaling in Lupus Designing synthetic microcapsules that undergo biomimetic communication and autonomous motion Arsenic promotes NF-κB-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs Genetic sharing and heritability of paediatric age of onset autoimmune diseases Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation Particle dynamics and deposition in true-scale pulmonary acinar models The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease Clusterin seals the ocular surface barrier in mouse dry eye The protein complex of neurodegeneration-related phosphoinositide phosphatase Sac3 and ArPIKfyve binds the Lewy-body-associated Synphilin-1 preventing its aggregation Anesthesia-induced neuronal apoptosis in the developing retina: a window of opportunity Oct1 and OCA-B are selectively required for CD4 memory T cell function Practical experience of the application of a weighted burden test to whole exome sequence data for obesity and schizophrenia Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 G93A mouse model of amyotrophic lateral sclerosis Agonist antibody that induces human malignant cells to kill one another Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality Nephron organoids derived from human pluripotent stem cells model kidney development and injury Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review Identification and characterization of essential genes in the human genome Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions A basal stem cell signature identifies aggressive prostate cancer phenotypes Neural stem cells rescue cognitive and motor dysfunction in a transgenic model of dementia with Lewy Bodies through a BDNF-dependent mechanism An epigenetic pathway regulates sensitivity of breast cancer cells to HER2 inhibition via FOXO/c-Myc axis Sleep disruption impairs haematopoietic stem cell transplantation in mice A skin-inspired organic digital mechanoreceptor Direct tumor recognition by a human CD4+ T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses Myeloid dysregulation in a human induced pluripotent stem cell model of PTPN11-associated juvenile myelomonocytic leukemia Blood-derived CD4 T cells naturally resist pyroptosis during abortive HIV-1 infection Lack of neuronal IFN-β-IFNAR causes Lewy body- and Parkinson’s Disease-like dementia Partial loss of Rpl11 in adult mice recapitulates Diamond-Blackfan anemia and promotes lymphomagenesis Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo Galectin-1 prevents infection and damage induced by Trypanosoma cruzi on cardiac cells Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer Childhood to early-midlife systolic blood pressure trajectories: early-life predictors, effect modifiers, and adult cardiovascular outcomes Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling A modular, DNA-based beacon for single-step fluorescence detection of antibodies and other proteins Disruption of histone methylation in developing sperm impairs offspring health transgenerationally An aminopeptidase in the Drosophila testicular niche acts in germline stem cell maintenance and spermatogonial dedifferentiation Antioxidants can increase melanoma metastasis in mice In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells Reconstruction and simulation of neocortical microcircuitry Poroelastic foams for simple fabrication of complex soft robots Plasticity-driven individualization of olfactory coding in mushroom body output neurons A metabolome-wide association study of kidney function and disease in the general population Functional classification of memory CD8+ T cells by CX3CR1 expression Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: a report of one case Ratios of T-cell immune effectors and checkpoint molecules as prognostic biomarkers in diffuse large B-cell lymphoma: a population-based study Human α7 integrin gene (ITGA7) delivered by adeno-associated virus extends survival of severely affected dystrophin/utrophin-deficient mice Human endogenous retrovirus-K contributes to motor neuron disease Structural basis for gene regulation by a B12-dependent photoreceptor LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation A novel locus of resistance to severe malaria in a region of ancient balancing selection Multiple repressive mechanisms in the hippocampus during memory formation Mondo-Mlx mediates organismal sugar sensing through the gli-similar transcription factor Sugarbabe Arrhythmogenic effects of mutated L-type Ca2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans SiR–Hoechst is a far-red DNA stain for live-cell nanoscopy Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination Excision of unstable artificial gene-specific inverted repeats mediates scar-free gene deletions in Escherichia coli MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells Human satellite cell transplantation and regeneration from diverse skeletal muscles Remote control of therapeutic T cells through a small molecule–gated chimeric receptor Arterial blood, rather than venous blood, is a better source for circulating melanoma cells Neurogenin 3 expressing cells in the human exocrine pancreas have the capacity for endocrine cell fate Human pluripotent stem cell-derived neural constructs for predicting neural toxicity Insulin demand regulates β cell number via the unfolded protein response Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment Harnessing the multifunctionality in nature: a bioactive agent release system with self-antimicrobial and immunomodulatory properties Systematic identification of factors for provirus silencing in embryonic stem cells Three different pathways prevent chromosome segregation in the presence of DNA damage or replication stress in budding yeast High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells Neuronal differentiation of human mesenchymal stem cells using exosomes derived from differentiating neuronal cells Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans MYC disrupts the circadian clock and metabolism in cancer cells Co-culturing Escherichia coli O157:H7 with a non-pathogenic E. coli strain increases toxin production and virulence in a germ-free mouse model The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development Control of stochastic and induced switching in biophysical networks Association between vitamin D status and age-related macular degeneration by genetic risk Joint associations of diet, lifestyle, and genes with age-related macular degeneration Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukemia Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats Kinome-wide decoding of network-attacking mutations rewiring cancer signaling Unmasking determinants of specificity in the human kinome Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response Single-cell in situ RNA profiling by sequential hybridization Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons Direct conversion of normal and Alzheimer’s disease human fibroblasts into neuronal cells by small molecules Programmed synthesis of three-dimensional tissues Nerve growth factor gene therapy--activation of neuronal responses in Alzheimer disease Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia Sidekick 2 directs formation of a retinal circuit that detects differential motion Restoration of vision with ectopic expression of human rod opsin Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years Rapid 3D extrusion of synthetic tumor microenvironments Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death Characterizing the DNA damage response by cell tracking algorithms and cell features classification using high-content time-lapse analysis CD47 blockade triggers T cell–mediated destruction of immunogenic tumors Dally proteoglycan mediates the autonomous and nonautonomous effects on tissue growth caused by activation of the PI3K and TOR pathways Fetal microchimerism and maternal health: A review and evolutionary analysis of cooperation and conflict beyond the womb Polyol-silk bioink formulations as two-part room-temperature curable materials for 3D printing SpDamID: Marking DNA bound by protein complexes identifies Notch-dimer responsive enhancers Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis Disease-associated single-nucleotide polymorphisms from noncoding regions in juvenile idiopathic arthritis are located within or adjacent to functional genomic elements of human neutrophils and CD4+ T cells Adipose tissue-derived mesenchymal stromal cells protect mice infected with Trypanosoma cruzi from cardiac damage through modulation of anti-parasite immunity IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer Prostate sphere-forming stem cells are derived from the P63-expressing basal compartment Type 2 fibroblast growth factor receptor signaling preserves stemness and prevents differentiation of prostate stem cells from the basal compartment DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts Distinct EMT programs control normal mammary stem cells and tumour-initiating cells Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair PE and PS lipids synergistically enhance membrane poration by a peptide with anticancer properties Gene therapy fully restores vision to the all-cone Nrl−/−Gucy2e−/− mouse model of Leber Congenital Amaurosis-1 Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease Platform technology for scalable assembly of instantaneously functional mosaic tissues Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome Materials advances for next-generation ingestible electronic medical devices Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments Elevated mitochondrial bioenergetics and axonal arborization size are key contributors to the vulnerability of dopamine neurons Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity Role of tumor pericytes in the recruitment of myeloid-derived suppressor cells DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses Dipeptide species regulate p38MAPK–Smad3 signalling to maintain chronic myelogenous leukaemia stem cells Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of lymphoid-tissue-derived CD4 T cells Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions Association between vitamin D status and age-related macular degeneration by genetic risk Clinical actionability of multigene panel testing for hereditary breast and ovarian cancer risk assessment Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc−, the Na+-independent glutamate–cystine exchanger Preparation and characterisation of antibacterial silver-containing nanofibres for wound healing in diabetic mice A gene-based association method for mapping traits using reference transcriptome data Unjamming and cell shape in the asthmatic airway epithelium Designing synthetic microcapsules that undergo biomimetic communication and autonomous motion Characterization of a steroid receptor coactivator small molecule stimulator that overstimulates cancer cells and leads to cell stress and death Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage–derived VEGFA Complete biosynthesis of opioids in yeast Pancreatic cancer metastases harbor evidence of polyclonality AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues Retinal angiogenesis effects of TGF-ß1, and paracrine factors secreted from human placental stem cells in response to a pathological environment Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin K A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation Cell type–specific manipulation with GFP-dependent Cre recombinase Coacervate delivery of growth factors combined with a degradable hydrogel preserves heart function after myocardial infarction Differential connexin function enhances self-renewal in glioblastoma Embryonic stem cells license a high level of dormant origins to protect the genome against replication stress Fate of distal lung epithelium cultured in a decellularized lung extracellular matrix Commissural axonal corridors instruct neuronal migration in the mouse spinal cord A hyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation Clonal deletion prunes but does not eliminate self-specific αβ CD8+ T lymphocytes Advances in reprogramming-based study of neurologic disorders Plasticity of the human visual system after retinal gene therapy in patients with Leber’s congenital amaurosis Metabolic rescue in pluripotent cells from patients with mtDNA disease A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders The carbonic anhydrase inhibitor ethoxzolamide inhibits the mycobacterium tuberculosis PhoPR Regulon and Esx-1 secretion and attenuates virulence Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study Single-cell migration chip for chemotaxis-based microfluidic selection of heterogeneous cell populations NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury A microfluidic device for label-free, physical capture of circulating tumor cell clusters The mouse brain metabolome: region-specific signatures and response to excitotoxic neuronal injury PDGFB-based stem cell gene therapy increases bone strength in the mouse Near-infrared emitting and pro-angiogenic electrospun conjugated polymer scaffold for optical biomaterial tracking Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma Reinforcement of hydrogels using three-dimensionally printed microfibers Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion In vivo single-cell labeling by confined primed conversion The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering Low-dose irradiation enhances gene targeting in human pluripotent stem cells TLR-2 signaling promotes IL-17A production in CD4+CD25+Foxp3+ regulatory cells during oropharyngeal candidiasis Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood Endothelial NO-synthase gene-enhanced progenitor cell therapy for Pulmonary Arterial Hypertension: the PHACeT trial Inducing stem cell myogenesis using NanoScript Co-option of membrane wounding enables virus penetration into cells Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice The genetic landscape of hematopoietic stem cell frequency in mice CNTF gene therapy confers lifelong neuroprotection in a mouse model of human retinitis pigmentosa Metabolic rescue in pluripotent cells from patients with mtDNA disease Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells Positively charged oligo[poly(ethylene glycol) fumarate] scaffold implantation results in a permissive lesion environment after spinal cord injury in rat Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes Targeting the microRNA passenger strand for regulating therapeutic transgenes Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo Recurrent fusion genes in gastric cancer: CLDN18-ARHGAP26 induces loss of epithelial integrity Novel protein Callipygian defines the back of migrating cells Infusion of human bone marrow-derived mesenchymal stem cells alleviates autoimmune nephritis in a lupus model by suppressing follicular helper T cell development Spraying respiratory epithelial cells to coat tissue-engineered constructs Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus Long-lived plasma cells are contained within the CD19−CD38hiCD138+ subset in human bone marrow Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation Atomic gold–enabled three-dimensional lithography for silicon mesostructures Ets factors regulate neural stem cell depletion and gliogenesis in Ras pathway glioma Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer’s disease Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis Self-organizing human cardiac microchambers mediated by geometric confinement Lymphatic vessels arise from specialized angioblasts within a venous niche Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte Digital microfluidic immunocytochemistry in single cells Quantification of retinogenesis in 3D cultures reveals epigenetic memory and higher efficiency in iPSCs derived from rod photoreceptors Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression Somatic mutations and clonal hematopoiesis in aplastic anemia Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration Are migraineurs naturally born “well-hearted”? Nanotubes mediate niche–stem-cell signalling in the Drosophila testis Trophic effects of dental pulp stem cells on Schwann cells in peripheral nerve regeneration Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome Autoantibody-targeted treatments for acute exacerbations of idiopathic pulmonary fibrosis A highly elastic and rapidly crosslinkable elastin-like polypeptide-based hydrogel for biomedical applications A highly elastic and rapidly crosslinkable elastin-like polypeptide-based hydrogel for biomedical applications Genetic analysis for a shared biological basis between migraine and coronary artery disease Quantification of retinogenesis in 3D cultures reveals epigenetic memory and higher efficiency in iPSCs derived from rod photoreceptors Broad anti-tumor activity of a small molecule that selectively targets the Warburg Effect and lipogenesis Determination of the action spectrum of UVR-induced mitochondrial DNA damage in human skin cells High IFN-γ and low SLPI mark severe asthma in mice and humans Cell-cell communication in yeast using auxin biosynthesis and auxin responsive CRISPR transcription factors Bivalent separation into univalents precedes age-related meiosis I errors in oocytes Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression HIV-specific immunity derived from chimeric antigen receptor-engineered stem cells Magnetic levitation of single cells Decay in survival motor neuron and plastin 3 levels during differentiation of iPSC-derived human motor neurons T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection MicroRNA-132 enhances transition from inflammation to proliferation during wound healing A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort Histone demethylases KDM4A and KDM4C regulate differentiation of embryonic stem cells to endothelial cells MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging Skipped-stimulus approach reveals that short-term plasticity dominates synaptic strength during ongoing activity Three-year outcomes of bariatric surgery vs lifestyle intervention for type 2 diabetes mellitus treatment: a randomized clinical trial Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells Cell death during crisis is mediated by mitotic telomere deprotection Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization Xenogeneic mesenchymal stromal cells improve wound healing and modulate the immune response in an extensive burn model Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model Quiescence of memory CD8 T cells is mediated by regulatory T cells through inhibitory receptor CTLA-4 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus Autologous olfactory lamina propria transplantation for chronic spinal cord injury: three-year follow-up outcomes from a prospective double blinded clinical trial Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles Krt19+/Lgr5−cells are radioresistant cancer-initiating stem cells in the colon and intestine Preclinical and clinical evidence of mycobacterium tuberculosis persistence in the hypoxic niche of bone marrow mesenchymal stem cells after therapy In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis SIV encephalitis lesions are composed of CD163+ macrophages present in the central nervous system during early SIV infection and SIV-positive macrophages recruited terminally with AIDS Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal ATM couples replication stress and metabolic reprogramming during cellular senescence Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening Siglec receptors impact mammalian lifespan by modulating oxidative stress Massively parallel delivery of large cargo into mammalian cells with light pulses Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output Direct in vivo assessment of human stem cell graft–host neural circuits Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells Improvement and decline in vision with gene therapy in childhood blindness Global developmental gene programing involves a nuclear form of fibroblast growth factor receptor-1 (FGFR1) Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes Federal regulatory oversight of US clinics marketing adipose-derived autologous stem cell interventions: insights from 3 new FDA draft guidance documents Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in asian patients Functional integration of human neural precursor cells in mouse cortex Perinatal outcomes and unconventional natural gas operations in southwest Pennsylvania Functional integration of human neural precursor cells in mouse cortex Calcium release channel RyR2 regulates insulin release and glucose homeostasis The innate immune system contributes to tissue-engineered vascular graft performance A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis G&T-seq: parallel sequencing of single-cell genomes and transcriptomes Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4+ T cells New self-assembling multifunctional templates for the biofabrication and controlled self-release of cultured tissue Twenty-four-hour intraocular pressure patterns in patients with thyroid eye disease Chemically fixed autologous feeder cell-derived niche for human induced pluripotent stem cell culture Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos Neurovascular crosstalk between interneurons and capillaries is required for vision FOXO1 differentially regulates both normal and diabetic wound healing Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown Galanin modulates the neural niche to favour perineural invasion in head and neck cancer Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy Ultrasound-induced modulation of cardiac rhythm in neonatal rat ventricular cardiomyocytes Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3 Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy Evaluation of postural control in patients with glaucoma using a virtual reality environment The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential An emerging era of clinical benefit from gene therapy Outcomes following gene therapy in patients with severe Wiskott-Aldrich Syndrome Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure Repression of SRF target genes is critical for Myc‐dependent apoptosis of epithelial cells Molecular remodeling of the presynaptic active zone of Drosophila photoreceptors via activity-dependent feedback A single epidermal stem cell strategy for safe ex vivo gene therapy Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment Regulatory T cells are not a strong predictor of survival for patients with glioblastoma Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis Innate lymphoid cells control early colonization resistance against intestinal pathogens through ID2-dependent regulation of the microbiota A prevascularized subcutaneous device-less site for islet and cellular transplantation The suture provides a niche for mesenchymal stem cells of craniofacial bones Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells Three-dimensional imaging of biological cells with picosecond ultrasonics Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity Real-time visualization of nanoparticles interacting with glioblastoma stem cells Towards protein-based viral mimetics for cancer therapies Serum- glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway In situ vascularization of injectable fibrin/poly(ethylene glycol) hydrogels by human amniotic fluid-derived stem cells CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung Trauma in silico: individual-specific mathematical models and virtual clinical populations Faster T-cell development following gene therapy compared to haplo-identical hematopoietic stem cell transplantation in the treatment of SCID-X1 Modeling familial cancer with induced pluripotent stem cells Functional analysis of the engineered cardiac tissue grown on recombinant spidroin fiber meshes YAP1 regulates OCT4 activity and SOX2 expression to facilitate self-renewal and vascular mimicry of stem-like cells High-resolution whole-brain staining for electron microscopic circuit reconstruction A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth Bending gradients: how the intestinal stem cell gets its home Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro Human iPSC-derived neural progenitors preserve vision in an AMD-like model Enhancement of radiation effect on cancer cells by gold-pHLIP Efficiency of conditionally attenuated Salmonella enterica serovar typhimurium in bacterium-mediated tumor therapy Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness Robust enumeration of cell subsets from tissue expression profiles Genetic and functional characterization of clonally derived adult human brown adipocytes The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells Predicting internal cell fluxes at sub-optimal growth Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response Patterned and functionalized nanofiber scaffolds in three-dimensional hydrogel constructs enhance neurite outgrowth and directional control Novel advancements in three-dimensional neural tissue engineering and regenerative medicine Telomerase mutations in smokers with severe emphysema Telomere dysfunction causes alveolar stem cell failure Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells Inflammatory dysregulation of blood monocytes in Parkinson's disease patients Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice Acoustic separation of circulating tumor cells Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic ipsc lines Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson’s disease Designing dual-functionalized gels for self-reconfiguration and autonomous motion In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation? A computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury Achieving synchronization with active hybrid materials: Coupling self-oscillating gels and piezoelectric films Embryonic origin of postnatal neural stem cells Embryonic stem cell–derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue Diabetes primes neutrophils to undergo NETosis, which impairs wound healing Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model A new technique for modeling neuronal connectivity using human pluripotent stem cells MtDNA mutagenesis disrupts pluripotent stem cell function by altering redox signaling A combined omics approach to generate the surface atlas of human naive CD4 T cells during early TCR activation Decrease in cell volume generates contractile forces driving dorsal closure Potent cell-intrinsic immune responses in dendritic cells facilitate HIV-1-specific T cell immunity in HIV-1 elite controllers Optical imaging of the chorioretinal vasculature in the living human eye Transcription factor PRDM8 is required for rod bipolar and type 2 OFF-cone bipolar cell survival and amacrine subtype identity Generation of induced pluripotent stem cells from frozen buffy coats using non-integrating episomal plasmids Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome Real-time imaging of dendritic cell responses to sterile tissue injury hESC differentiation toward an autonomic neuronal cell fate depends on distinct cues from the co-patterning vasculature High graft CD8 cell dose predicts improved survival and enables better donor selection in allogeneic stem-cell transplantation with reduced-intensity conditioning Dynamical system modeling of immune reconstitution after allogeneic stem cell transplantation identifies patients at risk for adverse outcomes Human embryonic stem cell-derived progenitors assist functional sensory regeneration after dorsal root avulsion injury A unique gene regulatory network resets the human germline epigenome for development Cell fusion connects oncogenesis with tumor evolution Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells Modulation of cell function by electric field: a high-resolution analysis Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children Aging-induced stem cell mutations as drivers for disease and cancer A noisy linear map underlies oscillations in cell size and gene expression in bacteria Can metabolic mechanisms of stem cell maintenance explain aging and the immortal germline? Programming and reprogramming cellular age in the era of induced pluripotency Stem cell aging and sex: are we missing something? Single transcription factor conversion of human blood fate to NPCs with CNS and PNS developmental capacity Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture Potential of systemic allogeneic mesenchymal stromal cell therapy for children with recessive dystrophic epidermolysis bullosa Prmt5 is a regulator of muscle stem cell expansion in adult mice 3D printing of highly stretchable and tough hydrogels into complex, cellularized structures Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1 Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces Folding and imaging of DNA nanostructures in anhydrous and hydrated deep-eutectic solvents Allogeneic neural stem/progenitor cells derived from embryonic stem cells promote functional recovery after transplantation into injured spinal cord of nonhuman primates Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis Chromothripsis from DNA damage in micronuclei T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms KPC and NDM-1 genes in related Enterobacteriaceae strains and plasmids from Pakistan and the United States Posttraumatic stress disorder and incident heart failure among a community-based sample of US veterans Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice Characterization of host and microbial determinants in individuals with latent Tuberculosis infection using a human granuloma model Incomplete immune reconstitution despite virologic suppression in HIV-1 infected children and adolescents Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart In vitro generation of human pluripotent stem cell derived lung organoids Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage Fidgetin-like 2: a microtubule-based regulator of wound healing Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68 A novel risk score to predict cardiovascular disease risk in national populations (Globorisk): a pooled analysis of prospective cohorts and health examination surveys Neuromedin S-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice MG53-mediated cell membrane repair protects against acute kidney injury Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing Transgenic mice with a diverse human T cell antigen receptor repertoire Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice Deletion of macrophage vitamin D receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells In vivo study of magnesium plate and screw degradation and bone fracture healing Collisions of deformable cells lead to collective migration Targeting bacteria via iminoboronate chemistry of amine-presenting lipids Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping Liver-directed lentiviral gene therapy in a dog model of hemophilia B ChIP-nexus enables improved detection of in vivo transcription factor binding footprints Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties Virus-specific T lymphocytes home to the skin during natural dengue infection DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs Elucidating molecular phenotypes caused by the SORL1 Alzheimer’s disease genetic risk factor using human induced pluripotent stem cells Lymphoid regeneration from Gene-corrected SCID-X1 subject-derived iPSCs Surgery versus nonsurgical treatment of lumbar spinal stenosis: a randomized trial Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium Wireless magnetothermal deep brain stimulation An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics Disruption of DNA-methylation-dependent long gene repression in Rett syndrome Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone Human Ebola virus infection results in substantial immune activation Systemic administration of epothilone B promotes axon regeneration after spinal cord injury Human Leukocyte Antigen (HLA) A*1101-restricted Epstein-Barr virus-specific T-cell receptor gene transfer to target Nasopharyngeal carcinoma Notch1–Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population Media Portray Unrealistic Timelines for Stem Cell Therapies Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue Interplay between population firing stability and single neuron dynamics in hippocampal networks An aptamer-functionalized chemomechanically modulated biomolecule catch-and-release system Mitochondrial membrane potential is regulated by vimentin intermediate filaments Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance Immunological mechanisms of the antitumor effects of supplemental oxygenation Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells Cartilage repair using human embryonic stem cell-derived chondroprogenitors Mouse mammary stem cells express prognostic markers for triple-negative breast cancer Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children Hepatic stellate cell‐expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage A small-molecule screen for enhanced homing of systemically infused cells In vivo generation of a mature and functional artificial skeletal muscle Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma Genetic studies of body mass index yield new insights for obesity biology Zyxin antagonizes the FERM protein expanded to couple F-actin and yorkie-dependent organ growth Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia An evolutionary role for HIV latency in enhancing viral transmission A hardwired HIV latency program DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior Individual T helper cells have a quantitative cytokine memory Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells Differentiation of hypothalamic-like neurons from human pluripotent stem cells Th17 inflammation model of oropharyngeal candidiasis in immunodeficient mice Visual impairment and blindness avoided with ranibizumab in hispanic and non-hispanic whites with diabetic macular edema in the United States (-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization (LMP) Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1R onto the primary cilium associated with cilia elongation Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma Integrative analysis of 111 reference human epigenomes Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema Self-assembled hydrogels utilizing polymer–nanoparticle interactions Engineering gold nanotubes with controlled length and near-infrared absorption for theranostic applications Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq Mechanical stress and network structure drive protein dynamics during cytokinesis Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction A conserved regulatory logic controls temporal identity in mouse neural progenitors Resetting the transcription factor network reverses terminal chronic hepatic failure Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy Force-controlled patch clamp of beating cardiac cells Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17–producing CD4+ T cells 64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signaling in cancer Pharmacological activation of myosin II paralogs to correct cell mechanics defects Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack Human umbilical cord blood cells induce neuroprotective change in gene expression profile in neurons after ischemia through activation of Akt pathway A light-inducible CRISPR-Cas9 system for control of endogenous gene activation Blood biocompatibility of surface-bound multi-walled carbon nanotubes Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition Monoterpene (−)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor B-lymphocyte-mediated delayed cognitive impairment following stroke Expenditures and health status among adults with back and neck problems Repression of intestinal stem cell function and tumorigenesis through direct phosphorylation of β-catenin and Yap by PKCζ Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice Class-switched memory B cells remodel BCRs within secondary germinal centers HIV-1 integration landscape during latent and active infection Human iPSC-derived hepatocyte-like cells support plasmodium liver-stage infection in vitro NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells Real-time deformability cytometry: on-the-fly cell mechanical phenotyping Disruption of the head direction cell network impairs the parahippocampal grid cell signal Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophages Maturation of embryonic tissues in a lymph node: a new approach for bioengineering complex organs Dental pulp stem cells: a new cellular resource for corneal stromal regeneration Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage Brush-like polycarbonates containing dopamine, cations, and PEG providing a broad-spectrum, antibacterial, and antifouling surface via one-step coating Modeling the natural history of Pelizaeus–Merzbacher disease Common genetic variants influence human subcortical brain structures Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells Rapid formation of a supramolecular polypeptide–DNA hydrogel for in situ three-dimensional multilayer bioprinting Derivation of hair-inducing cell from human pluripotent stem cells KLRG+ invariant natural killer T cells are long-lived effectors Highly angiogenic peptide nanofibers Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs Differential prooxidative effects of the green tea polyphenol, (–)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress Foxo1 inhibits diabetic mucosal wound healing but enhances healing of normoglycemic wounds Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer Hematopoietic stem cell transplantation for MS--extraordinary evidence still needed Association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability in patients with relapsing-remitting multiple sclerosis Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice Multiple myeloma Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus Time-resolved video analysis and management system for monitoring cardiomyocyte differentiation processes and toxicology assays An intermittent rocking platform for integrated expansion and differentiation of human pluripotent stem cells to cardiomyocytes in suspended microcarrier cultures Conjoint propagation and differentiation of human embryonic stem cells to cardiomyocytes in a defined microcarrier spinner culture Considerations in designing systems for large scale production of human cardiomyocytes from pluripotent stem cells A role of autophagy in PTP4A3-driven cancer progression Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy Programming thermoresponsiveness of nanovelcro substrates enables effective purification of circulating tumor cells in lung cancer patients Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells Variation in the human immune system is largely driven by non-heritable influences Chimeric antigen receptor T Cells for sustained remissions in leukemia Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons Amplifying the red-emission of upconverting nanoparticles for biocompatible clinically used prodrug-induced photodynamic therapy Fast sorting of CD4+ T cells from whole blood using glass microbubbles DNA brick crystals with prescribed depths Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms Severity of age-related macular degeneration in 1 eye and the incidence and progression of age-related macular degeneration in the fellow eye Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts Vascular channels formed by subpopulations of PECAM1+ melanoma cells Treatment of chronic graft-versus-host disease with bortezomib An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non–cell autonomous neurodegeneration Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts Murine and human tissue-engineered esophagus form from sufficient stem/progenitor cells and do not require microdesigned biomaterials EphA4 receptor shedding regulates spinal motor axon guidance The cavefish genome reveals candidate genes for eye loss Rapid modelling of cooperating genetic events in cancer through somatic genome editing Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission DNA-based digital tension probes reveal integrin forces during early cell adhesion Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease Actin stress in cell reprogramming CD8 T cells in innate immune responses: using STAT4-dependent but antigen-independent pathways to gamma interferon during viral infection Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency Innate lymphoid cells regulate intestinal epithelial cell glycosylation Quantitative SD-OCT imaging biomarkers as indicators of age-related macular degeneration progression BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy Engineered coiled-coil protein microfibers The e-incubator: a magnetic resonance imaging-compatible mini incubator Chronic hypertension increases susceptibility to acute IOP challenge in rats Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter Enteric bacteria promote human and mouse norovirus infection of B cells CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells Nanoparticle-mediated binning and profiling of heterogeneous circulating tumor cell subpopulations Transdifferentiation of human fibroblasts to endothelial cells: role of innate immunity Cell-size control and homeostasis in bacteria Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors A biodegradable tri-component graft for anterior cruciate ligament reconstruction Crystal structure of Cas9 in complex with guide RNA and target DNA A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9 Dynamic acoustic field activated cell separation (DAFACS) An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks Small RNA changes en route to distinct cellular states of induced pluripotency Divergent reprogramming routes lead to alternative stem-cell states Genome-wide characterization of the routes to pluripotency Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers Human genetics shape the gut microbiome Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial Global prevalence of glaucoma and projections of glaucoma burden through 2040 A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential The common chymotrypsinogen C (CTRC) variant G60G (C.180T) increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American population Inhibiting EGFR clustering and cell proliferation with gold nanoparticles Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn Functional Toll-like receptors in primary first-trimester trophoblasts Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2 SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing Prospective evaluation of teleophthalmology in screening and recurrence monitoring of neovascular age-related macular degeneration--a randomized clinical trial Stem cell transplantation as a dynamical system: are clinical outcomes deterministic? In silico derivation of HLA-specific alloreactivity potential from whole exome sequencing of stem-cell transplant donors and recipients: understanding the quantitative immunobiology of allogeneic transplantation Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1 Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis Cellular complexity captured in durable silica biocomposites Mechanically encoded cellular shapes for synthesis of anisotropic mesoporous particles Synthetic fossilization of soft biological tissues and their shape-preserving transformation into silica or electron-conductive replicas A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants Activation of toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic-cell-mediated inflammatory responses A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α Deconstructing transcriptional heterogeneity in pluripotent stem cells Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis Nanomimics of host cell membranes block invasion and expose invasive malaria parasites Age-related variations in the methylome associated with gene expression in human monocytes and T cells Topoisomerases facilitate transcription of long genes linked to autism Topoisomerase 1 inhibition reversibly impairs synaptic function Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins Time-variant clustering model for understanding cell fate decisions Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow The timing of upper-layer neurogenesis is conferred by sequential derepression and negative feedback from deep-layer neurons Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer Nitric oxide mediates metabolic coupling of omentum-derived adipose to ovarian and endometrial cancer cells Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states Human limbal biopsy–derived stromal stem cells prevent corneal scarring Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts Selective conversion of fibroblasts into peripheral sensory neurons Modulation of the maladaptive stress response to manage diseases of protein folding Inorganic–organic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model Nanoprobes: inorganic–organic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage Panel-based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible, and more sensitive for variant detection, than exome sequencing The immune synapse clears and excludes molecules above a size threshold Long-term safety and efficacy of factor IX gene therapy in hemophilia B The angiogenic factor PlGF mediates a neuroimmune interaction in the spleen to allow the onset of hypertension PHD3 regulates EGFR internalization and signalling in tumours Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection An integrated catalog of reference genes in the human gut microbiome A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells A proteome-scale map of the human interactome network Protein tyrosine phosphatase–σ regulates hematopoietic stem cell–repopulating capacity Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentallyinduced dry eye syndrome Spatial and temporal diversity in genomic instability processes defines lung cancer evolution Reversal of cognitive decline: A novel therapeutic program Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells Combining random gene fission and rational gene fusion to discover near-infrared fluorescent protein fragments that report on protein–protein interactions Salivary gland cancer in BRCA-positive families--a retrospective review Magneto-fluorescent core-shell supernanoparticles Molecular convergence of neurodevelopmental disorders Stochastic variations of migration speed between cells in clonal populations A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis Life-long correction of hyperbilirubinemia with a neonatal liver-specific AAV-mediated gene transfer in a lethal mouse model of Crigler–Najjar Syndrome Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells Clonal dynamics of native haematopoiesis Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study A modified γ-retrovirus vector for X-linked severe combined immunodeficiency Cortical representations are reinstated by the hippocampus during memory retrieval Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential Quality assurance in diabetic retinal screening in South Africa Mitochondrial haplogroups are associated with severity of diabetic retinopathy Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae Gold nanoparticle-decellularized matrix hybrids for cardiac tissue engineering Nanoscale resistive switching in amorphous perovskite oxide (a-SrTiO3) memristors Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo Solid-to-fluid DNA transition inside HSV-1 capsid close to the temperature of infection Solid-to-fluid–like DNA transition in viruses facilitates infection Pulmonary macrophage transplantation therapy Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI Regulated assembly and disassembly of the yeast telomerase quaternary complex Anti-inflammatory therapy after selective laser trabeculoplasty Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes Bacterial quorum sensing molecule N-3-Oxo-Dodecanoyl-L-Homoserine Lactone causes direct cytotoxicity and reduced cell motility in human pancreatic carcinoma cells Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal Delivery of antibody mimics into mammalian cells via anthrax toxin protective antigen PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease Systematic discovery of novel ciliary genes through functional genomics in the zebrafish Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma Resetting transcription factor control circuitry toward ground-state pluripotency in human Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM The developmental potential of iPSCs is greatly influenced by reprogramming factor selection Enhanced re-endothelialization of acellular kidney scaffolds for whole organ engineering via antibody conjugation of vasculatures Specific roles for dendritic cell subsets during initiation and progression of psoriasis A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer The developmental potential of iPSCs is greatly influenced by reprogramming factor selection Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification PAX7 expression defines germline stem cells in the adult testis Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells Diversification of TAM receptor tyrosine kinase function Inhibition of JAK-STAT signaling stimulates adult satellite cell function Optical assay of erythrocyte function in banked blood The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum Natively inhibited Trypanosoma brucei Cathepsin B structure determined by using an x-ray laser A potential wound-healing-promoting peptide from salamander skin Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting Live human nasal epithelial cells (hNECs) on chip for in vitro testing of gaseous formaldehyde toxicity via airway delivery In vitro modeling of the neurovascular environment by coculturing adult human brain endothelial cells with human neural stem cells Mechanochemical actuators of embryonic epithelial contractility The effect of a connexin43-based peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial Loss and dysfunction of Vδ2+ γδ T cells are associated with clinical tolerance to malaria Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma An implantable microfluidic device for self-monitoring of intraocular pressure Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts Cell separation using tilted-angle standing surface acoustic waves Engineering patient-specific valves using stem cells generated from skin biopsy specimens Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages Improvement in spinal cord injury-induced bladder fibrosis using mesenchymal stem cell transplantation into the bladder wall Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis Assemblages: functional units formed by cellular phase separation A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity 28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence Molecular imaging reveals elevated VEGFR-2 expression in retinal capillaries in diabetes: a novel biomarker for early diagnosis Communication through resonance in spiking neuronal networks Bleb-driven chemotaxis of Dictyostelium cells How blebs and pseudopods cooperate during chemotaxis Native American ancestry is associated with severe diabetic retinopathy in Latinos Adipose derived stem cells and nerve regeneration Function of a Foxp3 cis-element in protecting regulatory T cell identity Use of differentiated pluripotent stem cells as replacement therapy for treating disease Synaptic dysregulation in a human iPS cell model of mental disorders Preparing the ground for tissue regeneration: from mechanism to therapy Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy Hand-held and integrated single-cell pipettes Generation of multipotent induced neural crest by direct reprogramming of human postnatal fibroblasts with a single transcription factor Detection of minimal residual disease in B lymphoblastic leukemia by high-throughput sequencing of IGH Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland Novel fusion transcripts associate with progressive prostate cancer Inhibition of Protein Phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells Sequential histone-modifying activities determine the robustness of transdifferentiation Collective and individual migration following the epithelial–mesenchymal transition Cytokinesis failure triggers Hippo tumor suppressor pathway activation Dissecting engineered cell types and enhancing cell fate conversion via CellNet CellNet: network biology applied to stem cell engineering The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy Forces driving epithelial wound healing Protein competition switches the function of COP9 from self-renewal to differentiation H3K4me3 breadth is linked to cell identity and transcriptional consistency Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex Interplay of matrix stiffness and protein tethering in stem cell differentiation Multimonth controlled small molecule release from biodegradable thin films Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays The role of stem cells in aesthetic surgery: fact or fiction? Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain Most genetic risk for autism resides with common variation Control of the survival and growth of human glioblastoma grafted into the spinal cord of mice by taking advantage of immunorejection Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells using a bacterial CRISPR/Cas RNA-guided endonuclease Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1 Surviving extreme exposure to ionizing radiation: Escherichia coli genes and pathways Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1 RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells The relationship of central foveal thickness to urinary iodine concentration in retinitis pigmentosa with or without cystoid macular edema Glial origin of mesenchymal stem cells in a tooth model system Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process Directing the behavior of active, self-oscillating gels with light Mesenchymal stem cells augment the adaptive response to eccentric exercise Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing Molecular extraction in single live cells by sneaking in and out magnetic nanomaterials Prevalence of age-related macular degeneration in a large European cohort: Results from the population-based Gutenberg Health Study Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity Network analysis of breast cancer progression and reversal using a tree-evolving network algorithm Heterogeneous tumor subpopulations cooperate to drive invasion Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators Cell-specific translational profiling in acute kidney injury Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells Relationship between leukocyte telomere length, telomerase activity, and hippocampal volume in early aging Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma ABCB5 is a limbal stem cell gene required for corneal development and repair Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation Kit regulates HSC engraftment across the human-mouse species barrier Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity Two sides of the same coin: stem cells in cancer and regenerative medicine Leukemia propagating cells rebuild an evolving niche in response to therapy Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells Abnormalities in human pluripotent cells due to reprogramming mechanisms Spatio‐temporally precise activation of engineered receptor tyrosine kinases by light Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy Three-dimensional cell migration does not follow a random walk Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers Genetic analysis of tissue glutathione concentrations and redox balance A combined magnetophoresis/dielectrophoresis based microbead array as high-throughput biomolecular tweezers The transcription factor titration effect dictates level of gene expression The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons Galvanotactic control of collective cell migration in epithelial monolayers Systematic screen of chemotherapeutics in Drosophila stem cell tumors Common genetic variants modulate pathogen-sensing responses in human dendritic cells Serpins promote cancer cell survival and vascular co-option in brain metastasis Defining cell-type specificity at the transcriptional level in human disease Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes Vaccination with tumor cells expressing IL-15 and IL-15Rα inhibits murine breast and prostate cancer A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex Clinical imaging in regenerative medicine Human immunodeficiency virus-1 tat protein increases the number of inhibitory synapses between hippocampal neurons in culture Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells Increased cerebral activation after behavioral treatment for memory deficits in MS Let's rehabilitate cognitive rehabilitation in multiple sclerosis An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial Wharton's jelly stem cells: A novel cell source for oral mucosa and skin epithelia regeneration A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop Bovine lactoferricin B induces apoptosis of human gastric cancer cell line AGS by inhibition of autophagy at a late stage Genome-wide consequences of deleting any single gene Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits TH17 cell differentiation is regulated by the circadian clock Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells “Zero-dimensional” single-walled carbon nanotubes Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes Filaments in curved streamlines: rapid formation of Staphylococcus aureus biofilm streamers Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity A role for intrathymic B cells in the generation of natural regulatory T cells miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1 IL-2–inducible T cell kinase tunes T regulatory cell development and is required for suppressive function Transcription factor induction of human oligodendrocyte progenitor fate and differentiation Dental pulp stem cells, a paracrine-mediated therapy for the retina Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT Plasmonic gold nanoparticles modified titania nanotubes for antibacterial application Effect of marihuana on intraocular and blood pressure in glaucoma Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon? A wireless intraocular pressure monitoring device with a solder-filled microchannel antenna Electrophysiological analysis of biopsy samples using elasticity as an inherent cell marker for cancer detection Cooperative, reversible self-assembly of covalently pre-linked proteins into giant fibrous structures A multiscale agent-based in silico model of liver fibrosis progression TRF2, but not TBP, mediates the transcription of ribosomal protein genes Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent notch signaling Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells Transplantation of mesenchymal stem cells to the brain by topical application in an experimental traumatic brain injury model Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects Cell therapy with G-CSF-mobilized stem cells in a rat osteoarthritis model CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation Lowest numbers of primary CD8+ T cells can reconstitute protective immunity upon adoptive immunotherapy Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of Multiple Sclerosis Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations Identification of specific cell-surface markers of adipose-derived stem cells from subcutaneous and visceral fat depots Introducing mixed-charge copolymers as wound dressing biomaterials Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development Reactivation of multiple viruses in patients with sepsis Numerical modelling of a healthy/malaria-infected erythrocyte in shear flow using dissipative particle dynamics method Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers Functional connectivity in the basal ganglia network differentiates PD patients from controls Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming Mesenchymal stem cells increase hippocampal neurogenesis and neuronal differentiation by enhancing the Wnt signaling pathway in Alzheimer’s disease model Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients Alcohol-related brain damage in humans Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study Rare mutations in RINT1 predispose carriers to breast and lynch syndrome-spectrum cancers Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance High-fidelity reproduction of spatiotemporal visual signals for retinal prosthesis Nucleic acid sensing by T cells initiates Th2 cell differentiation Small molecule capture and release from PEI-functionalized single walled carbon nanotubes with endoscopic ultrasound Preparation and evaluation of polyethyleneimine-single walled carbon nanotube conjugates as vectors for pancreatic cancer treatment Mesenchymal stem cells, neural lineage potential, heparan sulfate proteoglycans and the matrix Photoactivation of endogenous latent transforming growth factor–β1 directs dental stem cell differentiation for regeneration Long-term health of dopaminergic neuron transplants in Parkinson's disease patients Microbial profiling of combat wound infection through detection microarray and next-generation sequencing Mutant huntingtin is present in neuronal grafts in huntington disease patients Generation of organized germ layers from a single mouse embryonic stem cell Prospective randomized phase 2 trial of intensity modulated radiation therapy with or without oncolytic adenovirus-mediated cytotoxic gene therapy in intermediate-risk prostate cancer Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis Epigenomic comparison reveals activation of “seed” enhancers during transition from naive to primed pluripotency Reusable, robust, and accurate laser-generated photonic nanosensor Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation Aiolos promotes anchorage independence by silencing p66shc transcription in cancer cells Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells Brain pericytes acquire a microglial phenotype after stroke Molecular profiling of neurons based on connectivity Fluorogenic probes for live-cell imaging of the cytoskeleton The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm A Trio–Rac1–Pak1 signalling axis drives invadopodia disassembly ALIX is recruited temporarily into HIV-1 budding sites at the end of Gag assembly Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication Inhibition of mitochondrial protein import by mutant huntingtin Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo The dynamics of signaling as a pharmacological target Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate Automated telecommunication-based reminders and adherence with once-daily glaucoma medication dosing: the automated dosing reminder study Electronic monitoring to assess adherence with once-daily glaucoma medications and risk factors for nonadherence: the automated dosing reminder study Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds The role of indoleamine 2,3 dioxygenase in beneficial effects of stem cells in hind limb ischemia reperfusion injury Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia Transgene delivery via intracellular electroporetic nanoinjection A self-reconfiguring metamorphic nanoinjector for injection into mouse zygotes Precise patterning of silk microstructures using photolithography Silk protein lithography as a route to fabricate sericin microarchitectures Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer Enhanced anticancer efficacy by ATP-mediated liposomal drug delivery Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin High-dose interleukin-2 therapy for metastatic renal cell carcinoma: a contemporary experience Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation Geographic atrophy--a histopathological assessment Clonal selection in the germinal centre by regulated proliferation and hypermutation Stretched cell cycle model for proliferating lymphocytes Metastatic ovarian cancer cell malignancy is increased on soft matrices through a mechanosensitive Rho/ROCK pathway A proliferative burst during preadolescence establishes the final cardiomyocyte number Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging Tear film dynamics with evaporation, wetting, and time-dependent flux boundary condition on an eye-shaped domain Deficits in bioenergetics and impaired immune response in granulocytes from children with autism Prevention and screening programs for anterior cruciate ligament injuries in young athletes Exosomes as critical agents of cardiac regeneration triggered by cell therapy Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches Temporal perturbation of the Wnt signaling pathway in the control of cell reprogramming is modulated by TCF1 Intracerebral implantation of autologous peripheral blood stem cells in stroke patients: a randomized phase II study Fate of iPSCs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules DNA Ligase I is not essential for mammalian cell viability APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo A 3D sphere culture system containing functional polymers for large-scale human pluripotent stem cell production Astrocyte-encoded positional cues maintain sensorimotor circuit integrity Contact angle at the leading edge controls cell protrusion rate Enhancing adult nerve regeneration through the knockdown of retinoblastoma protein Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear Neurogenic potential of dental pulp stem cells isolated from murine incisors Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca2+ channel sulfhydration E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition A module of human peripheral blood mononuclear cell transcriptional network containing primitive and differentiation markers is related to specific cardiovascular health variables Modular extracellular sensor architecture for engineering mammalian cell-based devices RNA as a boiling-resistant anionic polymer material to build robust structures with defined shape and stoichiometry Regulatory interactions maintaining self-renewal of human embryonic stem cells as revealed through a systems analysis of P13K/AKT pathway Crosstalk and the evolution of specificity in two-component signaling In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells Extracellular O-linked N-acetylglucosamine is enriched in stem cells derived from human umbilical cord blood Total artificial heart in the pediatric patient with biventricular heart failure Tissue-engineered autologous vaginal organs in patients: a pilot cohort study Histone modification analysis by chromatin immunoprecipitation from a low number of cells on a microfluidic platform Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq Glaucoma – Diabetes of the brain: A radical hypothesis about its nature and pathogenesis Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway Three-dimensional printing of Hela cells for cervical tumor model in vitro Isolation of T cells from mouse oral tissues Designing bioinspired artificial cilia to regulate particle–surface interactions Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial Carbon nanotube chemiresistor for wireless pH sensing p53 activity is selectively licensed in the Drosophila stem cell compartment Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1–dependent mechanotransduction in endothelial cells to stimulate transendothelial migration Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7 SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel Multifunctional wearable devices for diagnosis and therapy of movement disorders Pretreatment-dependent surface chemistry of wood nanocellulose for pH-sensitive hydrogels Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson’s Disease Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke Estimating the effective density of engineered nanomaterials for in vitro dosimetry Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability Truncation of the E3 ubiquitin ligase component FBXO31 causes non-syndromic autosomal recessive intellectual disability in a Pakistani family Induction of human embryonic and induced pluripotent stem cells into urothelium Derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere-based culture Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape Both contractile axial and lateral traction force dynamics drive amoeboid cell motility Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer Gene therapy for Wiskott-Aldrich Syndrome—long-term efficacy and genotoxicity Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss Perivascular stromal cells as a potential reservoir of human cytomegalovirus Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells Haematopoietic stem cells require a highly regulated protein synthesis rate Growth and proliferation of human embryonic stem cells on fully synthetic scaffolds based on carbon nanotubes Inhibition of miR-25 improves cardiac contractility in the failing heart Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis Vascular endothelial growth factor-A and islet vascularization are necessary in developing, but not adult, pancreatic islets Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration De novo formation of insulin-producing “neo-β cell islets” from intestinal crypts Plasmonic interferometric sensor arrays for high-performance label-free biomolecular detection Single-cell analysis of K562 cells: An imatinib-resistant subpopulation is adherent and has upregulated expression of BCR-ABL mRNA and protein Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma Two-photon-triggered drug delivery via fluorescent nanovalves Mouse liver repopulation with hepatocytes generated from human fibroblasts Robust nonenzymatic hybrid nanoelectrocatalysts for signal amplification toward ultrasensitive electrochemical cytosensing Magnetic field-induced T cell receptor clustering by nanoparticles enhances T cell activation and stimulates antitumor activity Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells A Photochromic Agonist for μ-Opioid Receptors The ecology in the hematopoietic stem cell niche determines the clinical outcome in chronic myeloid leukemia The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity Application of platelet-rich plasma and platelet-rich fibrin in fat grafting: basic science and literature review Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering Central memory CD8+ T lymphocytes mediate lung allograft acceptance Responses of Staphylococcus aureus bacterial cells to nanocrystalline nickel nanostructures Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in a silicon nanowire microenvironment Imaging dynamic molecular signaling by the Cdc42 GTPase within the developing CNS Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia Transgenerational transmission of hyperactivity in a mouse model of ADHD Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in Fragile X Syndrome MicroRNAs located in the hox gene clusters are implicated in Huntington's disease pathogenesis Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial Hsp90-tau complex reveals molecular basis for specificity in chaperone action Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration Human iPSC-based modeling of late-onset disease via progerin-induced aging Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling An effective approach to prevent immune rejection of human ESC-derived allografts Antagonism of CD11b with neutrophil inhibitory factor (NIF) inhibits vascular lesions in diabetic retinopathy Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury HIV-1 persistence in CD4+ T cells with stem cell–like properties Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors Generation of iPSC lines from archived non-cryoprotected biobanked dura mater Long-term stability and safety of transgenic cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy Retinal detachment after open globe injury Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease Patients’ attitudes toward the donation of biological materials for the derivation of induced pluripotent stem cells Engineering cells with intracellular agent–loaded microparticles to control cell phenotype Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation Accurate prediction of drug-induced liver injury using stem cell-derived populations Collaborative care outcomes for pediatric behavioral health problems: a cluster randomized trial Early intervention to preempt major depression among older black and white adults Testing Turing’s theory of morphogenesis in chemical cells Novel processing of iron-manganese alloy-based biomaterials by inkjet 3-D printing Human placental trophoblasts confer viral resistance to recipient cells A randomized trial of protocol-based care for early septic shock Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1 Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial Feasibility of repairing glomerular basement membrane defects in Alport Syndrome Stem cell quiescence acts as a tumour suppressor in squamous tumours Glycolytic ATP fuels the plasma membrane calcium pump critical for pancreatic cancer cell survival Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library Transcriptional targeting of primary and metastatic tumor neovasculature by an adenoviral type 5 roundabout4 vector in mice Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling Adult rat retinal ganglion cells and glia can be printed by piezoelectric inkjet printing A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce antitumor activity in solid malignancies Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror Epithelial-to-mesenchymal transition enhances the cardioprotective capacity of human amniotic epithelial cells Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers Copper-transporting P-type ATPases use a unique ion-release pathway Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFβ3 expression contributes to the delay of epithelial wound healing in diabetic corneas Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells Silencing of RB1 and RB2/P130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation Giant Vesicle Arrays: A Simple and Versatile Method for the Formation of Arrays of Giant Vesicles with Controlled Size and Composition Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing Long-term efficient gene delivery using polyethylenimine with modified Tat peptide Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection Epithelial bridges maintain tissue integrity during collective cell migration In vivo reprogramming of adult somatic cells to pluripotency by overexpression of Yamanaka factors Co-culture with mesenchymal stem cells results in improved viability and function of human hepatocytes Distinct fibroblast lineages determine dermal architecture in skin development and repair Adding spatial control to click chemistry: phototriggered diels–alder surface (bio)functionalization at ambient temperature (Bio)molecular surface patterning by phototriggered oxime ligation Spatially controlled surface immobilization of nonmodified peptides Spatially controlled surface immobilization of nucleophiles via trapping of photo-generated thioaldehydes Three-dimensional microscaffolds exhibiting spatially resolved surface chemistry Controlled cell adhesion on poly(dopamine) interfaces photopatterned with non-fouling brushes Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells Salmonella Typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr Virus latent membrane proteins Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA It’s time to bring dendritic cell therapy to type 1 diabetes Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of Alpha-1-antitrypsin deficiency Electrically controlled drug delivery from graphene oxide nanocomposite films Decellularized allogeneic and xenogeneic tissue as a bioscaffold for regenerative medicine: factors that influence the host response Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices Reaction-based fluorescent sensor for investigating mobile Zn2+ in mitochondria of healthy versus cancerous prostate cells Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images Quantifying cell-generated mechanical forces within living embryonic tissues Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A PKM2 regulates chromosome segregation and mitosis progression of tumor cells Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients Transcranial amelioration of inflammation and cell death after brain injury Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy Motor excitability during movement preparation in Tourette syndrome In vivo performance of a drug-eluting contact lens to treat glaucoma for a month A special population of regulatory T cells potentiates muscle repair Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis Histology of CorMatrix bioscaffold 5 Years after pericardial closure APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo Strategies for expanding the operational range of channelrhodopsin in optogenetic vision Structural basis for Ca2+ selectivity of a voltage-gated calcium channel Nanowell-trapped charged ligand-bearing nanoparticle surfaces: a novel method of enhancing flow-resistant cell adhesion c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny Sca1-derived cells are a source of myocardial renewal in the murine adult heart Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment Efficient generation of lung and airway epithelial cells from human pluripotent stem cells Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation Microbial colonization influences early B-lineage development in the gut lamina propria Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration EMRE is an essential component of the mitochondrial calcium uniporter complex Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease Metabolically active human brown adipose tissue derived stem cells Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells Human Treg responses allow sustained recombinant adeno-associated virus–mediated transgene expression Design and formulation of functional pluripotent stem cell-derived cardiac microtissues HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics The presenilin-1 ΔE9 mutation results in reduced -γsecretase activity, but not total loss of PS1 function, in isogenic human stem cells Chromosomal contact permits transcription between coregulated genes Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering Ultrasound-triggered regulation of blood glucose levels using injectable nano-network CD137 accurately identifies and enriches for naturally-occurring tumor-reactive T cells in tumor Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome Activated ClpP kills persisters and eradicates a chronic biofilm infection The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells SUMO1-dependent modulation of SERCA2a in heart failure SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases Psychobiotics: a novel class of psychotropic Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice JUNB/AP-1 controls IFN-γ during inflammatory liver disease Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells Intravenous multipotent adult progenitor cell therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury Computed tomography-guided tissue engineering of equine upper airway cartilage Nanotechnology in the regulation of stem cell behavior Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis Autologous transplantation as consolidation for aggressive non-hodgkin's lymphoma Differentiated kidney epithelial cells repair injured proximal tubule Plasmapheresis eliminates the negative impact of AAV antibodies on micro-dystrophin gene expression following vascular delivery A genetic and developmental pathway from STAT3 to the OCT4–NANOG circuit is essential for maintenance of ICM lineages in vivo Fiber-optic two-photon optogenetic stimulation Identification and rescue of α-synuclein toxicity in Parkinson patient–derived neurons Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias Targeted deletion of Vegfa in adult mice induces vision loss Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting Quantitative transcriptomics using designed primer-based amplification Harnessing interfacially-active nanorods to regenerate severed polymer gels Genome-wide association study of obsessive-compulsive disorder Genome-wide association study of Tourette's syndrome Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation Positional information is reprogrammed in blastema cells of the regenerating limb of the Axolotl (Ambystoma mexicanum) Molecular mechanisms of cellular mechanosensing Magneto-electric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian cancer cells Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury Biophysical regulation of epigenetic state and cell reprogramming A nanopore machine promotes the vectorial transport of DNA across membranes SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity Smurf2 regulates the senescence response and suppresses tumorigenesis in mice Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1 Multifunctional nanomedicine platform for concurrent delivery of chemotherapeutic drugs and mild hyperthermia to ovarian cancer cells Lower HIV provirus levels are associated with more APOBEC3G protein in blood resting memory CD4+ T lymphocytes Dielectrophoresis-based discrimination of bacteria at the strain level based on their surface properties Early outgrowth cells release soluble endocrine anti-fibrotic factors that reduce progressive organ fibrosis Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity DGIdb: mining the druggable genome Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention SLIT3–ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome Automatic diagnosis of pathological myopia from heterogeneous biomedical data Identification of neural connectivity signatures of autism using machine learning Spatial organization within a niche as a determinant of stem-cell fate Differentiated troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium Sustained release of bone morphogenetic protein 2 via coacervate improves the osteogenic potential of muscle-derived stem cells Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes Sox2+ stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential Induction and suppression of RNA silencing by an animal virus Antiviral RNA interference in mammalian cells RNA interference functions as an antiviral immunity mechanism in mammals Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome DNMT1-interacting RNAs block gene-specific DNA methylation Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas Retinal proteome alterations in a mouse model of type 2 diabetes Klotho regulates retinal pigment epithelial functions and protects against oxidative stress Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors 5-HT2 receptors facilitate JC polyomavirus entry Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance Integrative annotation of variants from 1092 humans: application to cancer genomics Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1 Dendritic epidermal T cells regulate skin antimicrobial barrier function Defining cell-type specificity at the transcriptional level in human disease How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function Simple, inexpensive technique for high-quality Smartphone fundus photography in human and animal eyes Identifying division symmetry of mouse embryonic stem cells: negative impact of DNA methyltransferases on symmetric self-renewal Directional tissue migration through a self-generated chemokine gradient Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a nonhuman primate CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation Pan-cancer patterns of somatic copy number alteration Paneth cells as a site of origin for intestinal inflammation mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation With an eye to low vision: optic flow enables perception despite image blur The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload Early human prostate adenocarcinomas harbor androgen-independent cancer cells Deterministic direct reprogramming of somatic cells to pluripotency Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1 Scalable spray deposition process for high-performance carbon nanotube gas sensors Flexible carbon nanotube based gas sensors fabricated by large-scale spray deposition Fabrication of carbon nanotube thin films on flexible substrates by spray deposition and transfer printing Glassy dynamics in three-dimensional embryonic tissues Targeting sonic hedgehog-associated medulloblastoma through inhibition of aurora and polo-like kinases Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis Generation of effector memory T cell–based mucosal and systemic immunity with pulmonary nanoparticle vaccination Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene Smart-seq2 for sensitive full-length transcriptome profiling in single cells Biochemical and physical signal gradients in hydrogels to control stem cell behavior Single-cell Hi-C reveals cell-to-cell variability in chromosome structure Multifocal pupillography identifies retinal dysfunction in early age-related macular degeneration Macrophage phenotype in the mammary gland fluctuates over the course of the estrous cycle and is regulated by ovarian steroid hormones Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia Reprogramming in vivo produces teratomas and iPS cells with totipotency features Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance Usp16 contributes to somatic stem-cell defects in Down’s syndrome Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness Network-based stratification of tumor mutations Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines An experimental test on the probability of extinction of new genetic variants Retinal angiogenesis suppression through small molecule activation of p53 Identification of a rare coding variant in complement 3 associated with age-related macular degeneration A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells Human circulating PD-1+CXCR3CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq Superpixel classification based optic disc and optic cup segmentation for glaucoma screening Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene Genome engineering of drosophila with the CRISPR RNA-guided Cas9 nuclease Effects of sleep and wake on oligodendrocytes and their precursors Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma Cellular and synaptic architecture of multisensory integration in the mouse neocortex Functional consequences of platelet binding to T lymphocytes in inflammation Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial Adipose stem cell therapy for soft tissue reconstruction Technology, trends, and the future for people with spinal cord injury The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis Probing red blood cell morphology using high-frequency photoacoustics In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu2+-dependent aggregation pathway Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis Stomach cancer risk after treatment for Hodgkin lymphoma Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1) Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction In situ regulation of DC subsets and T cells mediates tumor regression in mice The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism Purification of cardiomyocytes from differentiating pluripotent stem cells using molecular beacons targeting cardiomyocyte-specific mRNA Migraine and structural changes in the brain: A systematic review and meta-analysis Genetic basis for in vivo daptomycin resistance in enterococci Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids Chemoprevention of prostate cancer by D,L-sulforaphane is augmented by pharmacological inhibition of autophagy Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension What can information-asymmetric games tell us about the context of Crick's ‘frozen accident’? Topoisomerases facilitate transcription of long genes linked to autism Self-assembled carbon nanotube honeycomb networks using a butterfly wing template as a multifunctional nanobiohybrid GATA-3 regulates the self-renewal of long-term hematopoietic stem cells Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice Two cells are better than one: Optimizing stem cell survival by co-grafting “helper” cells that offer regulated trophic support Neural progenitor cell survival in mouse brain can be improved by co-transplantation of helper cells expressing bFGF under doxycycline control Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53 Generation and characterization of spiking and non-spiking oligodendroglial progenitor cells from embryonic stem cells Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48 PET/MRI: applications in clinical imaging Richness of human gut microbiome correlates with metabolic markers Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity A new role for histone deacetylase 5 in the maintenance of long telomeres Potential protective effect of biphasic electrical stimulation against growth factor-deprived apoptosis on olfactory bulb neural progenitor cells through the brain-derived neurotrophic factor–phosphatidylinositol 3′-kinase/Akt pathway Cerebral organoids model human brain development and microcephaly IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds Global comparisons of lectin-glycan interactions using a database of analyzed glycan array data Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from non-mucinous pancreatic cysts Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation Deacetylase inhibition promotes the generation and function of regulatory T cells Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity Patterned prevascularised tissue constructs by assembly of polyelectrolyte hydrogel fibres Functional vascular endothelium derived from human induced pluripotent stem cells Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the multiethnic cohort study A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment Molecular crowding shapes gene expression in synthetic cellular nanosystems Mortality among patients admitted to strained intensive care units In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells Mesenchymal stem cells enhance the engraftment and myelinating ability of allogeneic oligodendrocyte progenitors in dysmyelinated mice Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis MC1R is a potent regulator of PTEN after UV exposure in melanocytes Population-based prognostic factors for survival in patients with Burkitt lymphoma: An analysis from the Surveillance, Epidemiology, and End Results database Bacteria activate sensory neurons that modulate pain and inflammation Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitides Muscle cells provide instructions for planarian regeneration T follicular helper cell dynamics in germinal centers Signatures of mutational processes in human cancer Pediatric intestinal failure–associated liver disease is reversed with 6 months of intravenous fish oil The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection Adult c-kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration De novo mutations in epileptic encephalopathies Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis Paternally expressed genes predominate in the placenta The epidermis comprises autonomous compartments maintained by distinct stem cell populations Onecut1 is essential for horizontal cell genesis and retinal integrity Low CSF concentration of mitochondrial DNA in preclinical Alzheimer's disease Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders Nano-imprinting lithography of P(VDF–TrFE–CFE) for flexible freestanding MEMS devices Obstructive sleep apnea and increased risk of glaucoma: a population-based matched-cohort study Single-cell optoporation and transfection using femtosecond laser and optical tweezers Rheumatoid arthritis increases the risk of deep vein thrombosis and pulmonary thromboembolism: a nationwide cohort study Low-frequency (<100 kHz), low-intensity (<100 mW/cm2) ultrasound to treat venous ulcers: A human study and in vitro experiments Spatial dynamics of chromosome translocations in living cells Connectomic reconstruction of the inner plexiform layer in the mouse retina Relationship between dry eye symptoms and pain sensitivity Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells Epoxyeicosanoids promote organ and tissue regeneration Efficient generation of human iPSCs by a synthetic self-replicative RNA Transforming fusions of FGFR and TACC genes in human glioblastoma The integrated landscape of driver genomic alterations in glioblastoma Localization of magnetic pills Can bioadhesive nanoparticles allow for 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Oral delivery of proteins by biodegradable nanoparticles Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres Regional localization within the bone marrow influences the functional capacity of human HSCs SIGIRR, a negative regulator of TLR/IL-1R signalling promotes microbiota dependent resistance to colonization by enteric bacterial pathogens Creating a false memory in the hippocampus AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency gene Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension 14-step synthesis of (+)-Ingenol from (+)-3-Carene Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance Imatinib-induced apoptosis Motile axonal mitochondria contribute to the variability of presynaptic strength Green biosynthesis of gold nanometre scale plates using the leaf extracts from an indigenous Australian plant Eucalyptus macrocarpa The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells Extended practice of a motor skill is associated with reduced metabolic activity in M1 Modeling the photoinduced reconfiguration and directed motion of polymer gels hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging Correction of diabetic hyperglycemia and amelioration of metabolic anomalies by minicircle DNA mediated glucose-dependent hepatic insulin production Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia Epithelial junctions maintain tissue architecture by directing planar spindle orientation Activated carbon cloth as support for mesenchymal stem cell growth and differentiation to osteocytes Human umbilical cord stromal stem cell express CD10 and exert contractile properties The importance of bystander effects in radiation therapy in melanoma skin-cancer cells and umbilical-cord stromal stem cells Growth and spontaneous differentiation of umbilical-cord stromal stem cells on activated carbon cloth Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity Optical control of mammalian endogenous transcription and epigenetic states Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism Premature cell senescence and T cell receptor–independent activation of CD8+ T cells in juvenile idiopathic arthritis Reactivating head regrowth in a regeneration-deficient planarian species Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells Myeloid/microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease TGFβ receptor mutations impose a strong predisposition for human allergic disease Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease Overcoming preexisting humoral immunity to AAV using capsid decoys The antagonistic modulation of Arp2/3 activity by N-WASP/WAVE2 and PICK1 defines dynamic changes in astrocyte morphology Special section guest editorial: optical methods of imaging in the skin Translating dosage compensation to trisomy 21 Wnt/β-catenin signaling triggers neuron reprogramming and regeneration in the mouse retina LRG1 promotes angiogenesis by modulating endothelial TGF-β signaling Molecular crowding shapes gene expression in synthetic cellular nanosystems Prospective randomized clinical evaluation of conventional single-bundle, anatomic single-bundle, and anatomic double-bundle anterior cruciate ligament reconstruction: 281 cases with 3- to 5-year follow-up Transient B cell depletion combined with apoptotic donor splenocytes induces xeno-specific T and B cell tolerance to islet xenografts Nanoengineering gold particle composite fibers for cardiac tissue engineering TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer Noncanonical autophagy promotes the visual cycle Disturbed sleep and inflammatory cytokines in depressed and nondepressed pregnant women: an exploratory analysis of pregnancy outcomes Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma Lentiviral hematopoietic stem cell gene therapy benefits Metachromatic Leukodystrophy Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich Syndrome Passive joint forces are tuned to limb use in insects and drive movements without motor activity SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice Heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression Magnetic targeting of human mesenchymal stem cells with internalized superparamagnetic iron oxide nanoparticles Positive feedback between PU.1 and the cell cycle controls myeloid differentiation Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity Insulin and IGF1 modulate turnover of polysialylated neuronal cell adhesion molecule (PSA-NCAM) in a process involving specific extracellular matrix components Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers Iron administration before stem cell harvest enables MR imaging tracking after transplantation DNA computation in mammalian cells: microRNA logic operations In vivo cardiac reprogramming contributes to zebrafish heart regeneration Tunable touch sensor and combined sensing platform: toward nanoparticle-based electronic skin A microparticle approach to morphogen delivery within pluripotent stem cell aggregates Cell-based therapy for ischemic stroke Engineered neural tissue for peripheral nerve repair Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich Syndrome Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase Chemical communication of antibiotic resistance by a highly resistant subpopulation of bacterial cells MBNL proteins repress ES-cell-specific alternative splicing and reprogramming Global epigenomic reconfiguration during mammalian brain development Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation Human placental trophoblasts confer viral resistance to recipient cells Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children Switchable telescopic contact lens β-globin gene transfer to human bone marrow for sickle cell disease Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury A comprehensive assessment of gait accelerometry signals in time, frequency and time-frequency domains In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation Influence of surface features on the adhesion of Staphyloccocus epidermidis to Ag–TiCN thin films Neurons within the same network independently achieve conserved output by differentially balancing variable conductance magnitudes The relationship between diabetic retinopathy and cognitive impairment Efficacy and safety of autologous bone marrow derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates Wnt activation in nail epithelium couples nail growth to digit regeneration Gold nanorod vaccine for respiratory syncytial virus Dapper antagonist of Catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntingtons Disease Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells Combinatorial temporal patterning in progenitors expands neural diversity A largely random AAV integration profile after LPLD gene therapy Scalable nano-bioprobes with sub-cellular resolution for cell detection MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner iPSC-derived β cells model diabetes due to glucokinase deficiency Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis Self-organization of bacterial biofilms is facilitated by extracellular DNA Intravital FLIM-FRET imaging reveals dasatinibinduced spatial control of Src in pancreatic cancer Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy In vivo–directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous Antigen-specific tolerance by autologous myelin peptide–coupled cells: a phase 1 trial in multiple sclerosis Posttranscriptional control of T cell effector function by aerobic glycolysis Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development InVERT molding for scalable control of tissue microarchitecture Geometric control of vascular networks to enhance engineered tissue integration and function Identification of small molecules for human hepatocyte expansion and iPS differentiation Mediation of protection and recovery from experimental autoimmune encephalomyelitis by macrophages expressing the human voltage-gated sodium channel NaV1.5 Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza Hypothermic storage of human hepatocytes for transplantation Stepwise evolution of essential centromere function in a Drosophila neogene Phase I/II trial of adeno-associated virus–mediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in pompe disease: initial safety and ventilatory outcomes Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function The perivascular niche regulates breast tumour dormancy Identification of unsafe human induced pluripotent stem cell lines using a robust surrogate assay for pluripotency WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs 11β-hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation A preclinical xenograft model identifies castration-tolerant cancer-repopulating cells in localized prostate tumors Recovery from overt type 1 diabetes ensues when immune tolerance and β cell formation are coupled with regeneration of endothelial cells in the pancreatic islets Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP High-performance, transparent, and stretchable electrodes using graphene–metal nanowire hybrid structures Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors CD4+CD73+ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppression Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus Nanoclays mediate stem cell differentiation and mineralized ECM formation on biopolymer scaffolds Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein The role of gene therapy in regenerative surgery: updated insights Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies Targeting immunosuppression for cancer therapy Depleting tumor-specific Tregs at a single site eradicates disseminated tumors Risk of cancer among workers exposed to trichloroethylene: analysis of three nordic cohort studies First autologous cell therapy of cerebral palsy caused by hypoxic-ischemic brain damage in a child after cardiac arrest—individual treatment with cord blood Percutaneous tibial nerve stimulation for the long-term treatment of overactive bladder: 3-year results of the STEP study Structural basis of actin filament nucleation by tandem W domains Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts Zwitterionic hydrogels implanted in mice resist the foreign-body reaction Matrix metalloproteinase-8 (collagenase-2) induces the expression of interleukins-6 and -8 in breast cancer cells Bioresorbable airway splint created with a three-dimensional printer Defining single molecular forces required to activate integrin and Notch signaling Identification of candidate genes encoding an LDL-C QTL in baboons Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response Do findings on routine examination identify patients at risk for primary open-angle glaucoma? Comment on “ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models” Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning A molecular roadmap of reprogramming somatic cells into iPS cells Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation VEGF induces TGF-β1 expression and myofibroblast transformation after glaucoma surgery SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury Epigenomic analysis of multilineage differentiation of human embryonic stem cells Young at heart Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later Agent Orange as a risk factor for high-grade prostate cancer Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development Prefrontal microcircuit underlies contextual learning after hippocampal loss Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria Human embryonic stem cells derived by somatic cell nuclear transfer Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients Three-dimensional hydrogel constructs for exposing cells to nanoparticles Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia Cognate antigen directs CD8+ T cell migration to vascularized transplants Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain Engineering bone tissue substitutes from human induced pluripotent stem cells Linear mesostructures in DNA–nanorod self-assembly Multicenter study of banked third party virus-specific T-cells to treat severe viral infections after hematopoietic stem cell transplantation Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk Chromosome-specific nonrandom sister chromatid segregation during stem-cell division Prospective evaluation of a molecular marker panel for prediction of recurrence and cancer-specific survival after radical cystectomy SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms Role of pericytes in skeletal muscle regeneration and fat accumulation Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35 Lutein/Zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4 Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial Highly elastic micropatterned hydrogel for engineering functional cardiac tissue Evidence for a common mechanism of SIRT1 regulation by allosteric activators A role for PVRL4-driven cell–cell interactions in tumorigenesis Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior Liver preservation with machine perfusion under full oxygenation using a new cell-free oxygen-carrier solution Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice 3D printed bionic ears Chitosan/poly(vinyl alcohol) hydrogel combined with Ad-hTGF-β1 transfected mesenchymal stem cells to repair rabbit articular cartilage defects Generation of integration-free and region-specific neural progenitors from primate fibroblasts Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila The dual role of mesenchymal stem cells in tumor progression The dual effect of mscs on tumour growth and tumour angiogenesis MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients Symptom severity predicts prolonged recovery after sport-related concussion, but age and amnesia do not Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimers disease Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats Bone marrow tinctures for cardiovascular disease: lost in translation Intracoronary injection of bone marrow derived mononuclear cells, early or late after acute myocardial infarction: effects on global left ventricular function four months results of the SWISS-AMI trial Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies Generation of oligodendroglial cells by direct lineage conversion Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer Effect of shock wave–facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure Regulation of stem cell therapies under attack in Europe: for whom the bell tolls A physical sciences network characterization of non-tumorigenic and metastatic cells A systematic genome-wide analysis of zebrafish protein-coding gene function Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells Regeneration and experimental orthotopic transplantation of a bioengineered kidney Intranasal delivery of pGDNF nanoparticles provides neuroprotection in the rat 6-hydroxydopamine model of Parkinson’s disease Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors Lower baseline prostate-specific antigen is associated with a greater overall survival benefit from sipuleucel-T in the Immunotherapy for Prostate Adenocarcinoma Treatment (IMPACT) trial Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells Cardiopoietic stem cell therapy in heart failure The C-CURE multicenter randomized trial with lineage-specified biologics Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells Micromanaging hepatitis C virus Treatment of HCV infection by targeting microRNA Amplifying genetic logic gates Rational design of a ligand-controlled protein conformational switch Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration Tissue engineering and regenerative medicine: recent innovations and the transition to translation Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels Autophagy in stem cells FIP200 is required for maintenance and differentiation of postnatal neural stem cells Mesenchymal stem cells engineered to inhibit complement-mediated damage Stromal cell identity influences the in vivo functionality of engineered capillary networks formed by co-delivery of endothelial cells and stromal cells Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking Intracellular aggregation of multimodal silica nanoparticles for ultrasound-guided stem cell implantation Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting The circadian clock gates the intestinal stem cell regenerative state Adhesion strength–based, label-free isolation of human pluripotent stem cells Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease specific patterns of cardiotoxicity Keratocyte fragments and cells utilize competing pathways to move in opposite directions in an electric field Assembly of complex cell microenvironments using geometrically docked hydrogel shapes Chimeric antigen receptor T cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo Laparoscopic pyeloplasty for ureteropelvic junction obstruction in infants Cell-based therapeutics: the next pillar of medicine CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia Regulation of stem cell fate in a three-dimensional micropatterned dual-crosslinked hydrogel system A tissue-like printed material Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4 Transgenic overexpression of ribonucleotide reductase improves cardiac performance The human placenta methylome Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44 Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo A human pancreatic beta cell G1/S molecule cell cycle atlas Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human beta cell replication: a revised model of human beta cell G1/S control An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state Generation of induced neurons via direct conversion in vivo Self-deployable current sources fabricated from edible materials Inflammatory bowel disease Nonxenogeneic growth and retinal differentiation of human induced pluripotent stem cells A localized Wnt signal orients asymmetric stem cell division in vitro Disparate individual fates compose robust CD8+ T cell immunity A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy Four-part leukocyte differential count based on sheathless microflow cytometer and fluorescent dye assay Genes for endosomal NHE6 and NHE9 are misregulated in autism brains Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain Temperature sculpting in yoctoliter volumes Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells Cytolytic nanoparticles attenuate HIV-1 infectivity Targeting the intracellular WT1 oncogene product with a therapeutic human antibody The human gene connectome as a map of short cuts for morbid allele discovery Novel higher-order epigenetic regulation of the Bdnf gene upon seizures EBF2 determines and maintains brown adipocyte identity Synaptic plasticity by antidromic firing during hippocampal network oscillations Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors Rab11 regulates cell–cell communication during collective cell movements Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci Outcomes of transplantation using various hematopoietic cell sources in children with Hurler's syndrome after myeloablative conditioning Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis Interplay of LRRK2 with chaperone-mediated autophagy Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome Improvement in poor graft function after allogeneic hematopoietic stem cell transplantation upon administration of mesenchymal stem cells from third-party donors: a pilot prospective study Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future ‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing Topical administration of allogeneic mesenchymal stem cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer Complement factor H variant increases the risk of age-related macular degeneration Seven new loci associated with age-related macular degeneration Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds Cell-free protein synthesis and assembly on a biochip Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice Independent category and spatial encoding in parietal cortex Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1 Dynamic regulatory network controlling TH17 cell differentiation An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation MCM proteins are negative regulators of hypoxia-inducible factor 1 Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma: New trends and future opportunities Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients RNAi–based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination Seven new loci associated with age-related macular degeneration Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems Development, characterization, and use of a porcine epiblast-derived liver stem cell line: ARS-PICM-19 Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities Virgin birth: engineered heart muscle from parthenogenetic stem cells Parthenogenetic stem cells for tissue-engineered heart repair A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Cystoid macular edema in retinitis pigmentosa patients without associated macular thickening Acanthamoeba keratitis associated with tap water use during contact lens cleaning: manufacturer guidelines need to change Three-dimensional spectral-domain optical coherence tomography data analysis for glaucoma detection Immobilization of heparan sulfate on electrospun meshes to support embryonic stem cell culture and differentiation Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution Identification of stem cells in small intestine and colon by marker gene Lgr5 In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration Epigenomic plasticity enables human pancreatic α to β cell reprogramming Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction Brain cells for grandmother A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarray to a clinical model Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery NANOG-dependent function of TET1 and TET2 in establishment of pluripotency Treatment of diabetes and long-term survival following insulin and glucokinase gene therapy Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis C-reactive protein and the incidence of macular degeneration—pooled analysis of 5 cohorts A cis-acting element in retroviral genomic RNA links Gag-Pol ribosomal frameshifting to selective viral RNA encapsidation Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis Regenerative biotechnological treatment Nanowire-based electrode for acute in vivo neural recordings in the brain Subretinal electronic chips allow blind patients to read letters and combine them to words Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels The epithelial-mesenchymal transition generates cells with properties of stem cells FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer FOXO3A directs a protective autophagy program in haematopoietic stem cells A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor Long noncoding RNAs with enhancer-like function in human cells Activating RNAs associate with Mediator to enhance chromatin architecture and transcription Perivascular mesenchymal progenitors in human fetal and adult liver Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia Transferring a synthetic gene circuit from yeast to mammalian cells Synthetic circuits integrating logic and memory in living cells Tcf15 primes pluripotent cells for differentiation Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration Mixed modeling of meta-analysis p-values (MixMAP) suggests multiple novel gene loci for low density lipoprotein cholesterol Cellular complexity captured in durable silica biocomposites Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex Extracting intracellular diffusive states and transition rates from single-molecule tracking data Calmodulin mutations associated with recurrent cardiac arrest in infants Long noncoding RNAs regulate adipogenesis Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress Evolutionary rate covariation in meiotic proteins results from fluctuating evolutionary pressure in yeasts and mammals Ras oncoproteins transfer from melanoma cells to T Cells and modulate their effector functions Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue Transplanted progenitors generate functional enteric neurons in the postnatal colon Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms Epidermal growth factor regulates hematopoietic regeneration after radiation injury The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression CD271+ bone marrow mesenchymal stem cells may provide a niche for dormant mycobacterium tuberculosis Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast An electrocorticographic brain interface in an individual with tetraplegia Comparative analysis of circulating endothelial progenitor cells in age-related macular degeneration patients using automated rare cell analysis (ARCA) and fluorescence activated cell sorting (FACS) LBR and Lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation Acidity generated by the tumor microenvironment drives local invasion A role for Schwann cell–derived neuregulin-1 in remyelination Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke Neuregulin-1 enhances depolarization-induced GABA release Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements The potential of apolipoprotein E4 to act as a substrate for primary cultures of hippocampal neurons Immunogenicity of induced pluripotent stem cells Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells Significance analysis of prognostic signatures Schizophrenia: A neurodevelopmental disorder — Integrative genomic hypothesis and therapeutic implications from a transgenic mouse model Quantitative visualization of DNA G-quadruplex structures in human cells Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria Reprogramming adult schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration Braveheart, a long noncoding RNA required for cardiovascular lineage commitment Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells Generation of an HIV resistant T-cell line by targeted “stacking” of restriction factors Relationship of aspirin use with age-related macular degeneration: association or causation? The association of aspirin use with age-related macular degeneration The 510(k) ancestry of a metal-on-metal hip implant Interstitial dendritic cell guidance by haptotactic chemokine gradients Cardiomyocyte proliferation contributes to heart growth in young humans A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury The 2013 International Society for Heart and Lung Transplantation guidelines for mechanical circulatory support: executive summary Injection of vessel-derived stem cells prevents dilated cardiomyopathy and promotes angiogenesis and endogenous cardiac stem cell proliferation in mdx/utrn−/− but not aged mdx mouse models for Duchenne muscular dystrophy Anticancer activity of rice callus suspension culture Microdystrophin ameliorates muscular dystrophy in the canine model of Duchenne muscular dystrophy Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy A pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells The impact of Crohn's disease genes on healthy human gut microbiota: a pilot study The cytoplasm of living cells behaves as a poroelastic material Evaluation of the cell viability of human wharton's jelly stem cells for use in cell therapy Abnormal fixation in individuals with age-related macular degeneration when viewing an image of a face Endothelial reconstitution by CD34+ progenitors derived from baboon embryonic stem cells Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation MUC1 vaccine for individuals with advanced adenoma of the colon: a cancer immunoprevention feasibility study Retinal vessel caliber is associated with the 10-year incidence of glaucoma In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor Engineering cell surfaces for orthogonal selectability Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response Dielectrophoresis based discrimination of human embryonic stem cells from differentiating derivatives CXCR5+ T helper cells mediate protective immunity against tuberculosis Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits A subpopulation of nociceptors specifically linked to itch RNA processing enables predictable programming of gene expression A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity Multiplex genome engineering using CRISPR/Cas systems RNA-guided human genome engineering via Cas9 Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species Reconfigurable assemblies of active, autochemotactic gels Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells Klf4 regulates the expression of slurp1, which functions as an immunomodulatory Peptide in the mouse cornea High dynamic range (HDR) imaging concept based signal enhancement method reduced the optical coherence tomography (OCT) measurement variability Detection of glaucoma progression by population and individual derived variability criteria Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8+ T cells Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation Maternal serum 25-hydroxyvitamin d and measures of newborn and placental weight in a U.S. multicenter cohort study How insulin engages its primary binding site on the insulin receptor Common variants in psychiatric risk genes predict brain structure at birth Functional characterization of piggyBat from the bat Myotis lucifugus unveils an active mammalian DNA transposon Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer Refinement in localization and identification of gene regions associated with Crohn Disease Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets Spikes in mammalian bipolar cells support temporal layering of the inner retina Reactivation of neural ensembles during the retrieval of recent and remote memory Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa Race and ethnicity in decisions about unrelated hematopoietic stem cell donation Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis Comorbidity in patients with branch retinal vein occlusion: case-control study Cord-blood engraftment with ex vivo mesenchymal-cell coculture Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8+ T cell priming ATP sequestration by a synthetic ATP-binding protein leads to novel phenotypic changes in Escherichia coli Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6) Circulatory antigen processing by mucosal dendritic cells controls CD8+ T cell activation Dystroglycan organizes axon guidance cue localization and axonal pathfinding Brown adipose tissue regulates glucose homeostasis and insulin sensitivity The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18 Long-term follow-up assessment of a phase 1 trial of angiogenic gene therapy using direct intramyocardial administration of an adenoviral vector expressing the VEGF121 cDNA for the treatment of diffuse coronary artery disease Role of km23-1 in RhoA/actin-based cell migration A novel alternative to cryo-preservation for the short term storage of stem cells for use in cell therapy using alginate encapsulation Long-term follow-up after gene therapy for Canavan disease Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues Engineering antigens for in situ erythrocyte binding induces T-cell deletion FMRP targets distinct mRNA sequence elements to regulate protein expression Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines Alkylation sensitivity screens reveal a conserved cross-species functionome Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion The structural basis of direct glucocorticoid-mediated transrepression Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2 Cell-specific multifunctional processing of heterogeneous cell systems in a single laser pulse treatment Influence of water on the structure and properties of PDMS-containing multiblock polyurethanes Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors Use of reprogrammed cells to identify therapy for respiratory papillomatosis Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1 Co-Injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2 Autologous mesenchymal stem cell–derived dopaminergic neurons function in parkinsonian macaques Creating a bio-hybrid signal transduction pathway: opening a new channel of communication between cells and machines Prostaglandin e2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury MEF promotes stemness in the pathogenesis of gliomas p27Kip1 directly represses Sox2 during embryonic stem cell differentiation Delayed saccadic eye movements in glaucoma Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells Microcarrier suspension cultures for high-density expansion and differentiation of human pluripotent stem cells to neural progenitor cells Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation Longitudinal outcome of isolated mitral repair in older patients: results from 14,604 procedures performed from 1991 to 2007 A versatile synthetic platform for a wide range of functionalized biomaterials Substantial expression of mature elastin in arterial constructs High-performance neuroprosthetic control by an individual with tetraplegia Intermittent fasting: A “new” historical strategy for controlling seizures? Generation of integration-free neural progenitor cells from cells in human urine Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors Autologous mesenchymal stem cell–derived dopaminergic neurons function in parkinsonian macaques Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia Prolonged strenuous exercise expands the population of developmentally early stem cells in bone marrow & mobilizes them into peripheral blood - evidence...supports a positive effect of physical activity on extension of life span at the level of stem cells No survival advantage after double umbilical cord blood (UCB) compared to single UCB transplant in children with hematological malignancy: results of the blood and marrow transplant clinical trials network (BMT CTN 0501) randomized trial Targeting histone deacetylases as a new strategy for graft versus host disease prevention Injectable polyethylene glycol-fibrinogen hydrogel adjuvant improves survival and differentiation of transplanted mesoangioblasts in acute and chronic skeletal-muscle degeneration Transposable elements reveal a stem cell specific class of long noncoding RNAs Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression Prevalence and predictors of Sjögren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis Motor recovery after spinal cord injury enhanced by strengthening corticospinal synaptic transmission Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications Single-cell-resolution imaging of the impact of notch signaling and mitosis on segmentation clock dynamics Robust photoregulation of GABAA receptors by allosteric modulation with a propofol analogue Epigenetic regulation of olfactory receptor gene expression by the Myb–MuvB/dREAM complex De novo derivation of proteomes from transcriptomes for transcript and protein identification Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome A human disease model of drug toxicity–induced pulmonary edema in a lung-on-a-chip microdevice A novel role for lipid droplets in the organismal antibacterial response Long noncoding RNAs with snoRNA ends Critical variables in the alignment of electrospun PLLA nanofibers Combining topographical and genetic cues to promote neuronal fate specification in stem cells A culture system to study oligodendrocyte myelination processes using engineered nanofibers Vitamin D receptor as a master regulator of the c-MYC/MXD1 network MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model Printing and prototyping of tissues and scaffolds Systemic TNFα gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer Use of reprogrammed cells to identify therapy for respiratory papillomatosis Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells Adult pancreas side population cells expand after β cell injury and are a source of insulin-secreting cells High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration Injectable preformed scaffolds with shape-memory properties In vivo directed differentiation of pluripotent stem cells for skeletal regeneration Continued DNA synthesis in replication checkpoint mutants leads to fork collapse Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides Phenotypic and functional characterization of the luminal cell hierarchy of the mammary gland Fat grafting’s past, present, and future-why adipose tissue is emerging as a critical link to the advancement of regenerative medicine HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes Lgr5+ve stem/progenitor cells contribute to nephron formation during kidney development Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors Attenuation of miR-126 activity expands HSC in vivo without exhaustion Stem cell therapy in equine tendon injury Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas A bimodular mechanism of calcium control in eukaryotes The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis Mitochondrial gene replacement in primate offspring and embryonic stem cells Towards germline gene therapy of inherited mitochondrial diseases ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium Regulation of pluripotency and self- renewal of ESCs through epigenetic- threshold modulation and mRNA pruning Improved working memory but no effect on striatal vesicular monoamine transporter type 2 after omega-3 polyunsaturated fatty acid supplementation Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis Glial progenitor cell–based treatment and modeling of neurological disease N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome Peripheral-blood stem cells versus bone marrow from unrelated donors Adoptive transfer of cytotoxic T lymphocytes targeting two different antigens limits antigen loss and tumor escape Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice In vivo maturation of functional renal organoids formed from embryonic cell suspensions Ultrasound-induced release of micropallets with cells Grp94 triage of mutant myocilin through ERAD subverts a more efficient autophagic clearance mechanism Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease Magnetic nanoparticle–mediated massively parallel mechanical modulation of single-cell behavior DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy Generation of functional thyroid from embryonic stem cells Imaging neural activity using Thy1-GCaMP transgenic mice Characterization of the inflammatory response to solid cancer metastases in the human brain Histopathological correlates of magnetic resonance imaging–defined chronic perinatal white matter injury Neural stem cell engraftment and myelination in the human brain Human neural stem cells induce functional myelination in mice with severe dysmyelination Pursuing the goal of a donor for everyone in need Use of reprogrammed cells to identify therapy for respiratory papillomatosis ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells Cardiovascular risk factors in hematopoietic cell transplantation (HCT) survivors: role in development of subsequent cardiovascular disease Human very small embryonic-like cells generate skeletal structures, in vivo Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk IFNγR signaling mediates alloreactive T cell trafficking and GvHD Genetic programs constructed from layered logic gates in single cells Offspring from oocytes derived from in vitro primordial germ cell–like cells in mice Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells DNA methylation plasticity of human adipose-derived stem cells in lineage commitment New susceptibility loci associated with kidney disease in type 1 diabetes A stable cranial neural crest cell line from mouse Longitudinal trends in resource use in an incident cohort of open-angle glaucoma patients: resource use in open-angle glaucoma Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase Micro glass ball embedded gels to study cell mechanobiological responses to substrate curvatures Long-distance growth and connectivity of neural stem cells after severe spinal cord injury Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells Differentiation of mouse pancreatic stem cells into insulin-producing cells by recombinant sendai virus-mediated gene transfer technology Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production A strong regenerative ability of cardiac stem cells derived from neonatal hearts Adiponectin gene therapy ameliorates high-fat, high-sucrose diet-induced metabolic perturbations in mice A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage Restoration of auditory evoked responses by human ES-cell-derived otic progenitors Controlling spatial organization of multiple cell types in defined 3D geometries Cancer regression in patients after transfer of genetically engineered lymphocytes Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells Induced pluripotency and oncogenic transformation are related processes Distinct contribution of stem and progenitor cells to epidermal maintenance Predicting the diagnosis of autism spectrum disorder using gene pathway analysis Identifying metalloproteins through X-ray fluorescence mapping and mass spectrometry Mesenchymal stem cell transplantation improves regional cardiac remodeling following ovine infarction Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer δ-Catenin is genetically and biologically associated with cortical cataract and future alzheimer-related structural and functional brain changes Diminished temporal coding with sensorineural hearing loss emerges in background noise Fasting enhances the response of glioma to chemo- and radiotherapy A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells Myocardial protection, perioperative management, and vascular biology Wireless power transfer to a cardiac implant Initiation of transcription-coupled repair characterized at single-molecule resolution Identification, proliferation, and differentiation of adult leydig stem cells NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development Direct reprogramming of fibroblasts into embryonic sertoli-like cells by defined factors An RNA virus hijacks an incognito function of a DNA repair enzyme LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens The sirtuin SIRT6 regulates lifespan in male mice Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration Amputation induces stem cell mobilization to sites of injury during planarian regeneration Nanostructuring platinum nanoparticles on multilayered graphene petal nanosheets for electrochemical biosensing ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein Virus-mediated shRNA knockdown of Nav1.3 in rat dorsal root ganglion attenuates nerve injury-induced neuropathic pain Macroporous nanowire nanoelectronic scaffolds for synthetic tissues Formation and optogenetic control of engineered 3D skeletal muscle bioactuators Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells Adipose stem cells can secrete angiogenic factors that inhibit hyaline cartilage regeneration Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cells Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia Differential trafficking of transport vesicles contributes to the localization of dendritic proteins A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes Partial nerve injury induces electrophysiological changes in conducting (uninjured) nociceptive and nonnociceptive DRG neurons: Possible relationships to aspects of peripheral neuropathic pain and paresthesias Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis TrxG and PcG proteins but not methylated histones remain associated with DNA through replication Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4 Continuous 24-Hour monitoring of intraocular pressure patterns with a contact lens sensor Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation The mouse lymph node as an ectopic transplantation site for multiple tissues Intestinal inflammation targets cancer-inducing activity of the microbiota Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase Feeder cells support the culture of induced pluripotent stem cells even after chemical fixation Serum- and stromal cell-free hypoxic generation of embryonic stem cell-derived hematopoietic cells in vitro, capable of multilineage repopulation of immunocompetent mice Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents post-traumatic arthritis First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood Transforming fusions of FGFR and TACC genes in human glioblastoma Proteasome inhibition alleviates SNARE-dependent neurodegeneration Sacrificial nanofibrous composites provide instruction without impediment and enable functional tissue formation Improvements in the life expectancy of type 1 diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study cohort Nicotinamide adenine dinucleotide phosphate oxidase (nox) in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice FAM83B mediates EGFR- and RAS-driven oncogenic transformation Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signaling Fate-restricted neural progenitors in the mammalian cerebral cortex Mosaic hydrogels: one-step formation of multiscale soft materials Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial Randomized, controlled trial of a sustained delivery formulation of 5-fluorouracil for the treatment of failing blebs Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood–retinal barrier dysfunction The intermediate filament vimentin regulates chondrogenesis of adult human bone marrow-derived multipotent progenitor cells Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury Rationally designed controlled release systems for periodontal disease that promote immunological homeostasis New reservoirs of HLA alleles: pools of rare variants enhance immune defense 1α,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells: therapeutic potential for hair regeneration Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts Transcription activator-like effector proteins induce the expression of the Frataxin gene Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding RhoC impacts the metastatic potential and abundance of breast cancer stem cells Direct observation of mammalian cell growth and size regulation Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision The mitochondrial targeting chaperone 14-3-3 regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity The RIG-I-like receptor LGP2 controls CD8+ T cell survival and fitness Transcription activator-like effector proteins induce the expression of the Frataxin gene Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc Microwave sintering and in vitro study of defect-free stable porous multilayered HAp–ZrO2 artificial bone scaffold Stem cell therapy for craniofacial bone regeneration: a randomized, controlled, feasibility trial A tissue-engineered jellyfish with biomimetic propulsion Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart Bioresorbable bone graft substitutes of different osteoconductivities: a histologic evaluation of osteointegration of poly(propylene glycol-co-fumaric acid)-based cement implants in rats Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation OX40 signaling favors the induction of TH9 cells and airway inflammation Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin Cholangiocarcinomas can originate from hepatocytes in mice Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells Dominance of the CD4+ T helper cell response during acute resolving hepatitis A virus infection Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s Disease Gain and loss of multiple functionally related, horizontally transferred genes in the reduced genomes of two microsporidian parasites Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation Rational design of cationic lipids for siRNA delivery Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo Asthmatic granulomatosis: a novel disease with asthmatic and granulomatous features High-definition fiber tractography of the human brain: neuroanatomical validation and neurosurgical applications Direct central nervous system delivery provides enhanced protection following vector mediated gene replacement in a severe model of Spinal Muscular Atrophy Glycerol supplementation enhances L. reuteri’s protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity Anti-inflammatory mesenchymal stem cells (MSC2) attenuate symptoms of painful diabetic peripheral neuropathy Ultraviolet radiation damages self noncoding RNA and is detected by TLR3 Aneuploidy as a mechanism for stress-induced liver adaptation Novel vascular endothelial growth factor gene delivery system-manipulated mesenchymal stem cells repair infarcted myocardium Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries Oligodendroglia metabolically support axons and contribute to neurodegeneration Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR’s Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s disease Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells High-throughput single-microparticle imaging flow analyzer Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues Targeted gene knockout by direct delivery of zinc-finger nuclease proteins Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study Adult hematopoietic progenitors are multipotent in chimeric mice Follicular dendritic cells emerge from ubiquitous perivascular precursors Soft fibrin gels promote selection and growth of tumorigenic cells Manual wheelchair skills capacity predicts quality of life and community integration in persons with spinal cord injury Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation Increased asymmetric and multi-daughter cell division in mechanically confined microenvironments Serum apolipoproteins are associated with systemic and retinal microvascular function in people with diabetes DNA methylome signature in rheumatoid arthritis Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle Muscular Dystrophy Induced pluripotent stem cells from patients with Huntington's Disease show CAG-repeat-expansion-associated phenotypes Synthetic homeostatic materials with chemo-mechano-chemical self-regulation Endoscopic therapy is effective for patients with chronic pancreatitis Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice Production and implantation of renal extracellular matrix scaffolds from porcine kidneys as a platform for renal bioengineering investigations De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly Can magnetic targeting of magnetically labeled circulating cells optimize intramyocardial cell retention? Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death Id proteins synchronize stemness and anchorage to the niche of neural stem cells Fates of murine pluripotent stem cell-derived neural progenitors following transplantation into mouse cochleae Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes Induced pluripotent stem cells from a spinal muscular atrophy patient Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach Embryonic stem cell potency fluctuates with endogenous retrovirus activity Self-formation of optic cups and storable stratified neural retina from human ESCs Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell–derived cardiac myocyte monolayers Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells The transcriptional and epigenomic foundations of ground state pluripotency Extracellular-matrix tethering regulates stem-cell fate Evolutionary selection of enzymatically synthesized semiconductors from biomimetic mineralization vesicles Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor Brain expression Genome-Wide Association Study (eGWAS) identifies human disease-associated variants Generation of an HIV-1-resistant immune system with CD34+ hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells Liver tissue engineering utilizing hepatocytes propagated in mouse livers in vivo Intracellular trafficking pathways involved in the gene transfer of nano-structured calcium phosphate-DNA particles Clonally dominant cardiomyocytes direct heart morphogenesis SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to Cardiomyocytes Differentiation of multipotent vascular stem cells contributes to vascular diseases Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions Human epidermal Langerhans Cells maintain immune homeostasis in skin by activating skin resident regulatory T cells Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin Optical tweezers studies on notch: single-molecule interaction strength is independent of ligand endocytosis Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons NF-κB inhibition delays DNA damage–induced senescence and aging in mice Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium Human ES- and iPS-derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice The PSA/lo prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks Circulating tumour cells in non-metastatic breast cancer: a prospective study Histone H1 depletion impairs embryonic stem cell differentiation Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells Mind bomb 1 is required for pancreatic β-cell formation Role of stem cells in human uterine leiomyoma growth Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates Light-triggered eradication of Acinetobacter baumannii by means of NO delivery from a porous material with an entrapped metal nitrosyl Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis A clinical and serologic comparison of African-American and Caucasian patients with systemic sclerosis Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives Prevention of allogeneic fetal rejection by tryptophan catabolism Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularization Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells Astrocytes secrete exosomes enriched with pro-apoptotic ceramide and prostate apoptosis response 4 (PAR-4): a potential mechanism of apoptosis induction in Alzheimer's disease (AD) Opiate antagonist prevents μ- and δ-opiate receptor dimerization to facilitate ability of agonist to control ethanol-altered natural killer cell functions and mammary tumor growth The landscape of cancer genes and mutational processes in breast cancer Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth Allele-specific p53 mutant reactivation Photovoltaic retinal prosthesis with high pixel density Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo Engineering bone tissue from human embryonic stem cells Cellular mechanical properties reflect the differentiation potential of adipose-derived mesenchymal stem cells Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant A peptide derived from endostatin ameliorates organ fibrosis Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients Gene therapy for aromatic l-amino acid decarboxylase deficiency Anticancer PAD inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity Glioma gene therapy using induced pluripotent stem cell derived neural stem cells Tumor tropism of intravenously injected human-induced pluripotent stem cell-derived neural stem cells and their gene therapy application in a metastatic breast cancer model Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia Risk and reward in stem cell products: a new model for stem cell product liability Regenerative medicine: DIY eye Restoration of vision after transplantation of photoreceptors Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries Enhanced homing permeability and retention of bone marrow stromal cells by noninvasive pulsed focused ultrasound In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells Identification of common variants associated with human hippocampal and intracranial volumes Inactivation of conserved c. elegans genes engages pathogen- and xenobiotic-associated defenses Host translational inhibition by pseudomonas aeruginosa exotoxin A triggers an immune response in caenorhabditis elegans C. elegans detects pathogen-induced translational inhibition to activate immune signaling Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy The adult human brain harbors multipotent perivascular mesenchymal stem cells Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures Small molecules enable highly efficient neuronal conversion of human fibroblasts Antibiotic resistance is prevalent in an isolated cave microbiome Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress De novo mutations revealed by whole-exome sequencing are strongly associated with autism Patterns and rates of exonic de novo mutations in autism spectrum disorders Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development ESCRT-III governs the Aurora B–mediated abscission checkpoint through CHMP4C Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells NOD2 triggers an interleukin-32–dependent human dendritic cell program in leprosy Nighttime intensivist staffing and mortality among critically ill patients The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration Self-renewing endodermal progenitor lines generated from human pluripotent stem cells NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components MRI-guided disruption of the blood-brain barrier using transcranial focused ultrasound in a rat model Rapid and sensitive detection of an intracellular pathogen in human peripheral leukocytes with hybridizing magnetic relaxation nanosensors A genome-wide association meta-analysis identifies new childhood obesity loci Direct observation of nanoparticle–cancer cell nucleus interactions Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells DNA/amphiphilic block copolymer nanospheres reduce asthmatic response in a mouse model of allergic asthma Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma Ultrathin transnasal endoscopy without sedation: the straight skinny Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video) A biohybrid device for the systemic control of acute inflammation Timing isn't everything: donor heart allocation in the present LVAD era Risk assessment for continuous flow left ventricular assist devices: does the destination therapy risk score work?: an analysis of over 1,000 patients Kidney attack Genome abnormalities precede prostate cancer and predict clinical relapse REST-mediated recruitment of polycomb repressor complexes in mammalian cells Blood-derived human ips cells generate optic vesicle–like structures with the capacity to form retinal laminae and develop synapses Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma Genome-wide polycomb target gene prediction in Drosophila melanogaster Multiple intravenous administrations of human umbilical cord blood cells benefit in a mouse model of ALS Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis DNA demethylation dynamics Acute exercise remodels promoter methylation in human skeletal muscle A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide Inhibiting autophagy during interleukin 2 immunotherapy promotes long term tumor regression A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells AAV2 gene therapy readministration in three adults with congenital blindness Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants Germline stem cells and follicular renewal in the postnatal mammalian ovary Production of offspring from a germline stem cell line derived from neonatal ovaries Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction A human stem cell model of early Alzheimer’s disease pathology in Down Syndrome Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice PNPASE regulates RNA import into mitochondria Correcting human mitochondrial mutations with targeted RNA import Blood-derived human ips cells generate optic vesicle–like structures with the capacity to form retinal laminae and develop synapses Direct reprogramming of fibroblasts into neural stem cells by defined factors Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure A model for personalized in vivo analysis of human immune responsiveness Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival Human platelet-rich plasma- and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo Bioactive peptides derived from vascular endothelial cell extracellular matrices promote microvascular morphogenesis and wound healing in vitro Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells Direct conversion of fibroblasts into stably expandable neural stem cells Wild-type microglia arrest pathology in a mouse model of Rett syndrome Self-assembled RNA interference microsponges for efficient siRNA delivery Generation of functional insulin-producing cells in the gut by Foxo1 ablation Multi-input RNAi-based logic circuit for identification of specific cancer cells Lumbar intraspinal injection of neural stem cells in patients with ALS: results of a phase I trial in 12 patients Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability Gene therapy for Leber Congenital Amaurosis caused by RPE65 mutations Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice Complement factor H binds malondialdehyde epitopes and protects from oxidative stress BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming Adult spinal cord radial glia display a unique progenitor phenotype Substance use disorder and the risk of open-angle glaucoma The determination of stem cell fate by 3D scaffold structures through the control of cell shape Scanning probe-enabled nanocombinatorics define the relationship between fibronectin feature size and stem cell fate Direct signaling from astrocytes to neurons in cultures of mammalian brain cells Extracellular Ca2+ acts as a mediator of communication from neurons to glia Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB Hierarchical genetic organization of human cortical surface area Towards regenerative therapy for cardiac disease A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism Synergistic effects of central nervous system-directed gene therapy and bone marrow transplantation in the murine model of infantile neuronal ceroid lipofuscinosis Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms A versatile synthetic platform for a wide range of functionalized biomaterials The development and fate of follicular helper T cells defined by an IL-21 reporter mouse Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2+-induced Ca2+release in a rodent model of heart failure Inflammatory ocular adverse events with the use of oral bisphosphonates: a retrospective cohort study Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients Nanocomposite materials with antimicrobial activity based on chitosan Cancer stem cell vaccination confers significant antitumor immunity Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer Functionalized conducting polymer nanodots for enhanced cell capturing: the synergistic effect of capture agents and nanostructures Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner Differentiation potential of germ line stem cells derived from the postnatal mouse ovary Production of offspring from a germline stem cell line derived from neonatal ovaries Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood Germline stem cells and follicular renewal in the postnatal mammalian ovary Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women Cooperation between both Wnt/β-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates Mechanical resuscitation of chemical oscillations in Belousov–Zhabotinsky gels Position-specific chemical modification and quantitative proteomics disclose protein orientation adsorbed on silica nanoparticles Isolation and in vitro expansion of human colonic stem cells De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome SUMO1-dependent modulation of SERCA2a in heart failure Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis CT angiography for safe discharge of patients with possible acute coronary syndromes Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition The competitive advantage of a dual-transporter system Intravital imaging of thymopoiesis reveals dynamic lympho-epithelial interactions Maintenance of muscle stem-cell quiescence by microRNA-489 Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment A metalloproteinase secreted by Streptococcus pneumoniae removes membrane mucin MUC16 from the epithelial glycocalyx barrier Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion Nanowired three-dimensional cardiac patches Development of skin-humanized mouse models of pachyonychia congenital Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics A systematic survey of loss-of-function variants in human protein-coding genes Truncations of titin causing dilated cardiomyopathy Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells Radiation-induced reprograming of breast cancer cells SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates Derivation and characterization of embryonic stem cells lines derived from transgenic fischer 344 and dark agouti rats HLA-mismatched renal transplantation without maintenance immunosuppression Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency Combinatorial activation and repression by seven transcription factors specify drosophila odorant receptor expression Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation Choice-specific sequences in parietal cortex during a virtual-navigation decision task Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement Tissue engineering a fetal membrane High levels of circulating CD34+ cells at autologous stem cell collection are associated with favourable prognosis in multiple myeloma A human memory T cell subset with stem cell–like properties PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation Genome-wide polycomb target gene prediction in Drosophila melanogaster Intraocular pressure and corneal biomechanics in an adult British population: the EPIC-Norfolk eye study Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing Direct lineage conversion of terminally differentiated hepatocytes to functional neurons Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection A rare penetrant mutation in CFH confers high risk of age-related macular degeneration Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3 Human oocytes reprogram somatic cells to a pluripotent state Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus Targeted focal adhesion kinase activation in cardiomyocytes protects the heart from ischemia/reperfusion injury Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling Adult mice generated from induced pluripotent stem cells Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity Effect of donor—recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells Engineered whole organs and complex tissues Inducible apoptosis as a safety switch for adoptive cell therapy Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state Interconversion between intestinal stem cell populations in distinct niches Lyn is a redox sensor that mediates leukocyte wound attraction in vivo Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141+XCR1+ dendritic cells Restoration of normal BMP signaling levels and osteogenic differentiation in FOP mesenchymal progenitor cells by mutant allele-specific targeting Hydrogen sulfide increases hepatic differentiation in tooth-pulp stem cells Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition Single-cell dissection of transcriptional heterogeneity in human colon tumors Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential Engineered cell homing Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers BRCA1 is an essential regulator of heart function and survival following myocardial infarction BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology Cigarette smoke induction of osteopontin (SPP1) mediates TH17 inflammation in human and experimental emphysema Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury Saccade-confounded image statistics explain visual crowding Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway Small molecule induction of human umbilical stem cells into myelin basic protein positive oligodendrocytes in a defined three-dimensional environment Time trends in the incidence and causes of blindness in Israel Incidence of legal blindness from age-related macular degeneration in Denmark: year 2000 to 2010 Spider silk inspired functional microthreads Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination Effective treatment of metastatic forms of Epstein-Barr virus–associated nasopharyngeal carcinoma with a novel adenovirus-based adoptive immunotherapy Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals Transplantation of human embryonic stem cells onto a partially wounded human cornea in vitro Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells Freeze-dried heart valve scaffolds A CD74-dependent MHC class I endolysosomal cross-presentation pathway Low-pressure foaming: a novel method for the fabrication of porous scaffolds for tissue engineering Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase Evaluation of endothelial cells differentiated from amniotic fluid-derived stem cells Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia Osteoblastic cells regulate the haematopoietic stem cell niche Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells Modeling hepatitis C virus infection using human induced pluripotent stem cells Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells Endothelial and perivascular cells maintain haematopoietic stem cells Distinguishing DNA by analog-to-digital-like conversion by using optofluidic lasers Prostaglandin E2 promotes intestinal tumor growth via DNA methylation Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's Disease families Genetic instability in neural stem cells: an inconvenient truth? Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa Embryonic stem cell trials for macular degeneration: a preliminary report Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-Like Syndrome characterized by germline PTEN, SDH, or KLLN alterations DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in polg mutator mice Generation of chimeric rhesus monkeys Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives A single autoimmune T cell receptor recognizes more than a million different peptides Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis Rejuvenation of regeneration in the aging central nervous system Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility Dendritic cells promote pancreatic viability in mice with acute pancreatitis Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age Fetal cells traffic to injured maternal myocardium and undergo cardiac differentiation Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome p63 regulates olfactory stem cell self-renewal and differentiation Antibody-based protection against HIV infection by vectored immunoprophylaxis Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling Demographic and geographic features of exfoliation glaucoma in 2 United States-based prospective cohorts The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2 Adult cardiac-resident MSC-like stem cells with a proepicardial origin Charge inversion, condensation and decondensation of DNA and polystyrene sulfonate by polyethylenimine Polycomb-repressed genes have permissive enhancers that initiate reprogramming MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut Bone marrow contributes simultaneously to different neural types in the central nervous system through different mechanisms of plasticity The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly FT1050 (16,16-dimethyl prostaglandin e2)-enhanced umbilical cord blood accelerates hematopoietic engraftment after reduced intensity conditioning and double umbilical cord blood transplantation A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis Adenovirus-associated virus vector–mediated gene transfer in hemophilia B A trial of intrapleural adenoviral-mediated interferon-α2b gene transfer for malignant pleural mesothelioma Th17 cells mediate clade-specific, serotype-independent mucosal immunity Implantation site and lesion topology determine efficacy of a human neural stem cell line in a rat model of chronic stroke ΔNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α Neural correlates of reliability-based cue weighting during multisensory integration Combination epigenetic therapy has efficacy in patients with refractory advanced non–small cell lung cancer In vivo sustained release of siRNA from solid lipid nanoparticles Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells Interleukin-2 and regulatory T cells in graft-versus-host disease Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells New gene functions in megakaryopoiesis and platelet formation Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation Prevalence of immune disease in patients with wounds presenting to a tertiary wound healing centre Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells Genetic and epigenetic defects in DNA repair lead to synthetic lethality of poly (ADP-ribose) polymerase (PARP) inhibitors in aggressive myeloproliferative disorders Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway Adoptive immunotherapy with autologous CD3/CD28-costimulated T-cells after fludarabine-based chemotherapy in patients with chronic lymphocytic leukemia Jamb and Jamc are essential for vertebrate myocyte fusion Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery A 2-step approach to myeloablative haploidentical stem cell transplantation: a phase 1/2 trial performed with optimized T-cell dosing Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's Disease Optimizing the societal benefits of the annual influenza vaccine: a stochastic programming approach Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa CAD/CAM-assisted breast reconstruction Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans lincRNAs act in the circuitry controlling pluripotency and differentiation Direct laser writing of 3D scaffolds for neural tissue engineering applications SUMO1-dependent modulation of SERCA2a in heart failure Axon regeneration pathways identified by systematic genetic screening in C. elegans The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis Pancreatic mesenchyme regulates epithelial organogenesis throughout development Isolation and in vitro expansion of human colonic stem cells ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma Mutational inactivation of STAG2 causes aneuploidy in human cancer Biochemical alterations associated with ALS Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling Stem cell gene expression programs influence clinical outcome in human leukemia Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells Derivation of insulin producing cells from human endometrial stromal stem cells and use in the treatment of murine diabetes Conversion of mouse and human fibroblasts into functional spinal motor neurons Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132 The lamina propria of adult human oral mucosa harbors a novel stem cell population Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells CD8α+ dendritic cells are the critical source of interleukin-12 that controls acute infection by toxoplasma gondii tachyzoites CD8α+ dendritic cells are an obligate cellular entry point for productive infection by listeria monocytogenes ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a menkes disease mouse model Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer Intravenous autologous bone marrow mononuclear cells for ischemic stroke Mutations in CIC and FUBP1 contribute to human oligodendroglioma Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma Risk assessment model for development of advanced age-related macular degeneration GeT peptides: a single-domain approach to gene delivery Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1 Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities Successful implantation of bioengineered, intrinsically innervated, human internal anal sphincter Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa Stimulating cardiac muscle by light RALA and RALBP1 regulate mitochondrial fission at mitosis LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against k562 chronic myeloid leukemia cells with modified citrus pectin Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder A resource of vectors and ES cells for targeted deletion of microRNAs in mice Notch post-translationally regulates β-catenin protein in stem and progenitor cells An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells Lineage restricted progenitors for the repopulation of decellularized heart Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection An unbiased genome-wide analysis of zinc-finger nuclease specificity Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins Mechanoregulation of vascularization in aligned tissue-engineered muscle: a role for vascular endothelial growth factor Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia Defining the nature of human pluripotent stem cell progeny Understanding the metabolic basis of drug resistance: Therapeutic induction of the Warburg effect kills cancer cells HIV-1 adaptation to NK-cell-mediated immune pressure Spider silk-based gene carriers for tumor cell-specific delivery Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions Engineered lentiviral vectors pseudotyped with a CD4 receptor and a fusogenic protein can target cells expressing HIV-1 envelope proteins Stem cell–mediated transfer of a human artificial chromosome ameliorates muscular dystrophy Visual data integration for imaging-based planning in human craniofacial transplantation Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD Clustering and activity tuning of Kv1 channels in myelinated hippocampal Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions Long-term outcome of patients with metastatic breast cancer treated with high-dose chemotherapy and transplantation of purified autologous hematopoietic stem cells Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition Bcl6 mediates the development of T follicular helper cells Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines Genetic engineering of human pluripotent cells using TALE nucleases Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction Observations on the remarkable (and mysterious) wound-healing process of the bottlenose dolphin Proinvasion metastasis drivers in early-stage melanoma are oncogenes Progesterone inhibits the growth of human neuroblastoma: in vitro and in vivo evidence Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia Precise manipulation of chromosomes in vivo enables genome-wide codon replacement Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function Functional regeneration of respiratory pathways after spinal cord injury MicroRNA-mediated conversion of human fibroblasts to neurons Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model Expression of apolipoprotein A-I in rabbit carotid endothelium protects against atherosclerosis Control of TH17 cells occurs in the small intestine Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain Dehydro-α-lapachone, a plant product with antivascular activity Intramyocardial, autologous CD34+ cell therapy for refractory angina Chemotactic cell trapping in controlled alternating gradient fields Transcriptome transfer provides a model for understanding the phenotype of cardiomyocytes One-pot synthesis of microcapsules with nanoscale inclusions Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse Purification of immature neuronal cells from neural stem cell progeny Non-viral gene delivery nanoparticles based on Poly(β-amino esters) for treatment of glioblastoma Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation Temporal dissection of tumorigenesis in primary cancers Upregulation of adipogenesis and chondrogenesis in MSC serum-free culture Integrated genomic analyses of ovarian carcinoma Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing MiR-34a chemo-sensitizes bladder cancer cells to cisplatin treatment regardless of P53-Rb pathway status Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine Cardiomyocytes Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors Altered telomeres in tumors with ATRX and DAXX mutations In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID) Multiple forms of activity-dependent competition refine hippocampal circuits in vivo Extracellular matrix powder protects against bleomycin-induced pulmonary fibrosis Identification and expansion of a unique stem cell population from adult mouse gallbladder Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice Nanomaterials for X-ray imaging: gold nanoparticle enhancement of X-ray scatter imaging of hepatocellular carcinoma In vivo genome editing restores haemostasis in a mouse model of haemophilia Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma Notch-dependent differentiation of adult airway basal stem cells Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors An analysis of high ferritin levels before allogeneic hematopoietic cell transplantation (AlloHCT): A retrospective study to evaluate prognostic factors in patients (pts) undergoing AlloHCT for myelodysplasia Nanoparticles that communicate in vivo to amplify tumour targeting Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform Graded Nodal/Activin signaling titrates conversion of quantitative Phospho-Smad2 levels into qualitative embryonic stem cell fate decisions Artificially induced protein–membrane anchorage with cholesterol-based recognition agents as a new therapeutic concept Radioimmunotherapy with Lu-177 labeled anti-CAIX monoclonal antibody in advanced renal cell carcinoma Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer Direct conversion of human fibroblasts to dopaminergic neurons Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequences First experience with a paracorporeal artificial lung in a small child with pulmonary hypertension Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis De novo cardiomyocytes from within the activated adult heart after injury RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation The impact of conversion from prograf to generic tacrolimus in liver and kidney transplant recipients with stable graft function A biochemical–biophysical study of hemoglobins from woolly mammoth, asian elephant, and humans An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells Determinants of nucleosome organization in primary human cells A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers The orphan disease networks α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1 Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling Genomic comparison of multi-drug resistant invasive and colonizing Acinetobacter baumannii isolated from diverse human body sites reveals genomic plasticity Induction of human neuronal cells by defined transcription factors Democracy derived? New trajectories in pluripotent stem cell research Specification of transplantable astroglial subtypes from human pluripotent stem cells Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast A low-dose insulin infusion suppresses the expression of β-amyloid precursor protein Post-progression treatment with APC8015F may have prolonged survival of subjects in the control arm of sipuleucel-T phase III studies Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex The use of mesenchymal stem cells in orthopedics: review of the literature, current research, and regulatory landscape Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells Kinase inhibitors modulate huntingtin cell localization and toxicity Polyvalent nucleic acid nanostructures Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's Disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity Autocrine effects of mesenchymal stem cells expressing IGF-I rescue the fracture-healing defects of Irs1 knockout mice Microstructured templates for directed growth and vascularization of soft tissue in vivo A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteins Three-dimensional polymer constructs exhibiting a tunable negative poisson's ratio Poly(lactic–co-glycolic acid): Carbon nanofiber composites for myocardial tissue engineering applications Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs Lrp5 functions in bone to regulate bone mass Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells Simultaneous visualization of both signaling cascade activity and end-point gene expression in single cells Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog Chromatin “prepattern” and histone modifiers in a fate choice for liver and pancreas Computational design of proteins targeting the conserved stem region of influenza hemagglutinin Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies Collective cell guidance by cooperative intercellular forces Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer Complete budding and asymmetric division of primitive model cells to produce daughter vesicles with different interior and membrane compositions High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition New adeno-associated virus strategies to support momentum in the clinic A simple method to increase the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo Systemic elimination of de novo capsid protein synthesis from replication-competent AAV contamination in the liver A versatile adeno-associated virus vector producer cell line method for scalable vector production of different serotypes Mycophenolate mofetil impairs transduction of single-stranded adeno-associated viral vectors Good manufacturing practice production of self-complementary serotype 8 adeno-associated viral vector for a hemophilia B clinical trial Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression C20-D3-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of Stargardt disease Deuterium enrichment of vitamin A at the C20 position slows the formation of detrimental vitamin A dimers in wild-type rodents Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2 Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel γδ intraepithelial lymphocytes are essential mediators of host–microbial homeostasis at the intestinal mucosal surface Object detection in the ring scotoma of a monocular bioptic telescope Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells Celecoxib inhibits Interleukin-6/Interleukin-6 receptor–induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells The Parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors Evidence for human lung stem cells Structurally distinct LewisX glycans distinguish subpopulations of neural stem/progenitor cells A hormone-dependent module regulating energy balance Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine Immunogenicity of induced pluripotent stem cells Delayed intrathecal delivery of RhoA siRNA to the contused spinal cord inhibits allodynia, preserves white matter, and increases serotonergic fiber growth Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis In vivo protein trapping produces a functional expression codex of the vertebrate proteome CD4+CD25+CD127dimFoxp3+ T cells are cytotoxic for human neurons Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model Composite scaffold provides a cell delivery platform for cardiovascular repair Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells Therapeutic cell engineering with surface-conjugated synthetic nanoparticles Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors Direct reprogramming of mouse fibroblasts to neural progenitors A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43 The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseases Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors Polycystin-1 regulates STAT activity by a dual mechanism Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of Nelfinavir Intramyocardial, autologous CD34+ cell therapy for refractory angina Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion Gastroesophageal reflux disease symptom severity, proton pump inhibitor use, and esophageal carcinogenesis CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice Combinatorial binding of transcription factors in the pluripotency control regions of the genome Engineering nanocarriers for siRNA delivery Vaults engineered for hydrophobic drug delivery Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex Use of whole-genome sequencing to diagnose a cryptic fusion oncogene Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease–mediated safe harbor targeting Pharmacological characterization of chemically synthesized monomeric phi29 pRNA nanoparticles for systemic delivery Assembly of therapeutic pRNA-siRNA nanoparticles using bipartite approach The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue A kinase shRNA screen links LATS2 and the pRB tumor suppressor DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly A new subtype of progenitor cell in the mouse embryonic neocortex PDGFRα-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia Modelling schizophrenia using human induced pluripotent stem cells Cutting edge: humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing Differentiation of induced pluripotent stem cells of swine into rod photoreceptors and their integration into the retina Gene therapy for pain: Results of a phase I clinical trial A rapid and scalable system for studying gene function in mice using conditional RNA interference Reversible suppression of an essential gene in adult mice using transgenic RNA interference ApoE isoform-specific regulation of regeneration in the peripheral nervous system Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function Control of pancreatic β cell regeneration by glucose metabolism A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability Microbial electricity generation via microfluidic flow control Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair Engineering a waste management enzyme to overcome cancer resistance to apoptosis: adding DNase1 to the anti-cancer toolbox Chronic ulcerative stomatitis: evidence of autoimmune pathogenesis Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair Quantification of the forces driving self-assembly of three-dimensional microtissues Polymalic acid–based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis Genome-wide association study identifies a common variant associated with risk of endometrial cancer Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models Self-organizing optic-cup morphogenesis in three-dimensional culture Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state Generation of bioengineered corneas with decellularized xenografts and human keratocytes Control of copper resistance and inorganic sulfur metabolism by paralogous regulators in Staphylococcus aureus Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation A nanomechanical interface to rapid single-molecule interactions A diverse range of gene products are effectors of the type I interferon antiviral response Human induced pluripotent stem-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized vascular endothelial growth factor secretion, and gene expression pattern similar to native RPE In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α–induced apoptosis and proliferation by MAPKs A randomized trial of the effect of patient race on physicians' intensive care unit and life-sustaining treatment decisions for an acutely unstable elder with end-stage cancer Characterization of KRAS rearrangements in metastatic prostate cancer Mutations in the RNA granule component TDRD7 cause cataract and glaucoma Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium Multipotent progenitor cells derived from adult peripheral blood of swine have high neurogenic potential in vitro Noise contributions in an inducible genetic switch: a whole-cell simulation study Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration Vitamin D status and early age-related macular degeneration in postmenopausal women Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis Targeted delivery of small interfering RNA using rHDL nanoparticles SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression Identification of novel and distinct binding sites within tenascin-c for soluble and fibrillar fibronectin Therapeutic targeting of SPINK1-positive prostate cancer Rapid modulation of local neural activity by controlled drug release from polymer-coated recording microelectrodes Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells Catecholamine receptor polymorphisms affect decision-making in C. elegans Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis Efficacy and safety of sirolimus in lymphangioleiomyomatosis The complexity hypothesis revisited: connectivity rather than function constitutes a barrier to horizontal gene transfer High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial Subthalamic GAD gene therapy in a Parkinson's disease rat model Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation Pancreatic cancers require autophagy for tumor growth Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration Myocardial infarction and cerebrovascular accident in patients with retinal vein occlusion Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome Rescue of lethal hepatic failure by hepatized lymph nodes in mice Parallel high-throughput RNA interference screens ident