Authors:
Jonas Croissant, Arnaud Chaix, Olivier Mongin, Miao Wang, Sébastien Clément, Laurence Raehm, Jean-Olivier Durand, Vincent Hugues, Mireille Blanchard-Desce, Marie Maynadier, Audrey Gallud, Magali Gary-Bobo, Marcel Garcia, Jie Lu, Fuyuhiko Tamanoi, Daniel P. Ferris, Derrick Tarn, and Jeffrey I. Zink
Summary:
Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore with a high two-photon absorption cross-section. The pores of the MSN filled with anticancer drug are blocked with a pseudo-rotaxane constituted by an azobenzene stalk and a β-cyclodextrin moiety. After incubation of the nanosystem with MCF-7 breast cancer cells, two-photon irradiation at low power is used to image the cells. At high power, cancer cell killing is observed due to the two-photon-triggered opening of the pores through FRET and the release of the anticancer drug from the MSN.
Source:
Small; (02/20/14)