Authors:
Gunda Herberth, PhD, Kirsten Offenberg, MSc, Ulrike Rolle-Kampczyk, PhD, Mario Bauer, PhD, Wolfgang Otto, PhD, Stefan Röder, PhD, Konrad Grützmann, Dipl.Bioinf, Ulrich Sack, PhD, Jan-Christoph Simon, PhD, Michael Borte, PhD, Martin von Bergen, PhD, Irina Lehmann, PhD, for the LINA Study Group
Summary:
The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is a pivotal host platform for sensing of endogenous and exogenous danger signals and for the subsequent orchestration of inflammatory responses. Beside pathogenic agents, endogenous dietary metabolites such as fatty acids can trigger the assembly of NLRP3 inflammasomes, cytosolic protein complexes that activate caspase-1 (CASP1), leading to the cleavage of pro–IL-1β and pro–IL-18.1 NLRP3 and the expression of pro forms of the IL-1β cytokine family are transcriptionally induced by Toll like receptor (TLR) activation.
Source:
The Journal of Allergy and Clinical Immunology; (2015)