Authors:
Ugutz Unzueta, María Virtudes Céspedes, Esther Vázquez, Neus Ferrer-Miralles, Ramón Mangues, & Antonio Villaverde
Summary:
High resistance and recurrence rates, together with elevated drug clearance, compel the use of maximum-tolerated drug doses in cancer therapy, resulting in high-grade toxicities and limited clinical applicability. Promoting active drug accumulation in tumor tissues would minimize such issues and improve therapeutic outcomes. A new class of therapeutic drugs suitable for the task has emerged based on the concept of virus-mimetic nanocarriers, or ‘artificial viruses’. Among the spectrum of materials under exploration in nanocarrier research, proteins offer unparalleled structural and functional versatility for designing virus-like molecular vehicles. By exhibiting ‘smart’ functions and biomimetic traits, protein-based nanocarriers will be a step ahead of the conventional drug–protein conjugates already in the clinic in ensuring efficient delivery of passenger antitumor drugs.
Source:
Trends in Biotechnology; Vol. 33, Issue 5, 253-258 (05/2015)