Authors: Maria Vega Almazán, Eduardo Ortega, Rosario Moreno Torres, Mercedes Tovar, Julio Romero, Miguel Ángel López-Casado, Laura Jáimez, Juan Jiménez-Jáimez, Alicia Ballesteros, Javier Caballero-Villarraso, José Maldonado
Summary: Background: Our aim is to study the prevalence of subclinical celiac disease (CD) and analyze the diagnostic yield of a new rapid test in children aged 2–4.
Methods: We carried out a cross-sectional study in a sample population of children aged 2–4 from the same metropolitan area. We recruited apparently healthy subjects, and collected clinical, anthropometric, analytical, and serological variables. We also tested for anti-gliadin IgA and anti-transglutaminase IgG and IgA using a rapid immunochromatographic test CD1WB and CD2WB (Operon, Zaragoza, Spain).
Results: One hundred and ninety-eight children were recruited, signed the informed consent form, and completed the protocol (mean age 32.3 ± 9.2 mo, 53% males). CD prevalence according to the serological tests was 3% (CI 95%, 1.4–6.4%). Biopsies were used to confirm the diagnosis in all suspected cases. The sensitivity and negative predictive value of the CD2WB immunochromatographic test strip were 100% and 1, respectively. The sensitivity of CD1WB was 16.6% and its specificity was high (89.1%).
Conclusion: The prevalence of subclinical CD in the sample group of 2–4-y old was higher than that found by other authors. The CD2WB immunochromatographic test strip is an excellent diagnostic screening tool with high sensitivity and negative predictive value.
Source:
Pediatric Research; 2015, 78 (3): 280