Authors: Rahimeh B. Atashgah, Amir Ghasemi, Mohammad Raoufi, Mohammad-Amin Abdollahifar, Steven Zanganeh, Hossein Nejadnik, Alieh Abdollahi, Shahriar Sharifi, Baltazar Lea, Miguel Cuerva, Mehdi Akbarzadeh, Carmen Alvarez-Lorenzo, Seyed Nasser Ostad, Andrea S. Theus, Doris L. LaRock, Christopher N. LaRock, Vahid Serpooshan, Rouzbeh Sarrafi, Ki-Bum Lee, Hojatollah Vali, Holger Schönherr, Lisa Gould, Pablo Taboada, Morteza Mahmoudi
Summary: Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.
Source: Molecular Pharmaceutics, 2021