Authors:
Juan Song, Jiaqi Sun, Jonathan Moss, Zhexing Wen, Gerald J Sun, Derek Hsu, Chun Zhong, Heydar Davoudi, Kimberly M Christian, Nicolas Toni, Guo-li Ming, & Hongjun Song
Summary:
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
Source:
Nature Neuroscience; 16, 1728-1730 (11/10/13)